islets

[Nature Reviews Endocrinology] The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.

[Scientific Reports] Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists comprehensively examined preproinsulin specificity of CD8 T cells obtained from pancreatic islets of organ donors with and without type 1 diabetes (T1D) and identified epitopes throughout the entire preproinsulin protein and defective ribosomal products derived from preproinsulin messenger RNA.

[Science Advances] The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.

[Islets] Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.

[Molecular Cancer] Investigators shed light on recent advances regarding the direct and indirect crosstalk between cancer-associated fibroblasts (CAFs) and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the tumor microenvironment.