islets

[Nature Communications] RNA-seq of purified recombined β-cells reveals transcriptomic consequences of Insr loss, which differ between female and male mice.

[Diabetes] Following beta cell ablation of Yy1, scientists observed rapid onset of hyperglycemia, impaired glucose tolerance and reduced beta cell mass in both neonates and adult mice.

[Nature Medicine] Researchers generated islets from human chemically induced PSCs (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.

[Cell Metabolism] By screening the expression and functional characterization of olfactory receptors in pancreatic islets, investigators identified Olfr109 as the receptor that detects insulin peptides.

[Cytotherapy] Scientists revealed that co-transplantation of umbilical cord mesenchymal stromal cella and autologous bone marrow mononuclear cells in patients with established type 1 diabetes was associated with reduced incidence of chronic diabetes complications.

[Experimental and Molecular Medicine] Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.