islets

[Peptides] Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.

[Diabetes] Scientists assessed the global protein and individual protein tyrosine phosphatases (PTP) profiles in the pancreas from early onset non-obese diabetic mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist.

[Experimental and Molecular Medicine] Researchers investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout mouse model.

[Cell Death & Disease] Overlapping analysis of H3K27Ac ChIP-seq and RNA-seq showed that the inhibitory effect of SB on the expression of multiple β cell identity genes was independent of H3K27Ac.

[Diabetes] Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.

[Nature Nanotechnology] Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.