keratinocytes

[Scientific Reports] Researchers investigated if α-tocopherol phosphate, a promising new antioxidant, could protect against long-wave UVA1 induced cell death and scavenge UVA1 induced reactive oxygen species in a skin cell model.

[Experimental Dermatology] The authors investigated the efficacy of the histone deacetylase inhibitor, Vorinostat, in targeting hyperproliferation and impaired apoptosis in psoriatic skin.

[Science Immunology] Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.

[PLoS Biology] Investigators reported that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the salvage pathway of NAD+ biosynthesis, reduced oxidative stress and cell death in zebrafish models of chronic skin inflammation.

[iScience] Logical model simulations describing the function of cytokine and eicosanoid signaling networks combined with experimental data suggest that T-helper (Th) 17 cytokines stimulate proinflammatory cytokine expression in psoriatic keratinocytes.

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.