NAMPT-Derived NAD⁺ Fuels PARP1 to Promote Skin Inflammation through Parthanatos Cell Death

Investigators reported that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the salvage pathway of NAD+ biosynthesis, reduced oxidative stress and cell death in zebrafish models of chronic skin inflammation.