Inhibition of Phospholipases Suppresses Progression of Psoriasis through Modulation of Inflammation

Investigators transfected si-PLA2G4B in a murine keratinocyte cell-line PAM212 to verify the effect of progression by PLA2G4B.
[Experimental Biology and Medicine]
Gao, Y., Lu, J., Bao, X., Yi, X., Peng, C., Chen, W., Zhen, T., Shi, Y., Xing, K., Zhu, S., & Ding, Y. (2021). Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation. Experimental Biology and Medicine, 1535370221993424. https://doi.org/10.1177/1535370221993424 Cite
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A Surfactant Polymer Wound Dressing Protects Human Keratinocytes from Inducible Necroptosis

Researchers showed that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by surfactant polymer dressing, allowing keratinocyte survival.
[Ca-A Cancer Journal For Clinicians]
Khandelwal, P., Das, A., Sen, C. K., Srinivas, S. P., Roy, S., & Khanna, S. (2021). A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis. Scientific Reports, 11(1), 4357. https://doi.org/10.1038/s41598-021-82260-x Cite
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Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging

Researchers isolated exosomes derived from umbilical cord MSCs grown in a 3D culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes.
[Rejuvenation Research]
Liu, S.-J., Meng, M.-Y., Han, S., Gao, H., Zhao, Y.-Y., Yang, Y., Lin, Z.-Y., Yang, L.-R., Zhu, K., Han, R., Huang, W.-W., Wang, R.-Q., Yang, L.-L., Wang, W.-J., Li, L., Wang, X.-D., Hou, Z.-L., Liao, L. W., & Yang, L. (2021). Umbilical cord mesenchymal stem cell-derived exosomes ameliorate HaCaT cell photo-aging. Rejuvenation Research. https://doi.org/10.1089/rej.2020.2313 Cite
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Generation of Functional Conjunctival Epithelium, Including Goblet Cells, from Human iPSCs

Scientists describe human conjunctival development in a self-formed ectodermal autonomous multi-zone of cells that were derived from human-iPSCs and mimic whole-eye development.
[Cell Reports]
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs: Cell Reports. (n.d.). Retrieved February 23, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00028-0 Cite
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Epitope Spreading toward Wild-Type Melanocyte-Lineage Antigens Rescues Suboptimal Immune Checkpoint Blockade Responses

Scientists report that patients with low melanoma neoantigen burdens who responded to ICI had tumors with higher expression of pigmentation-related genes.
[Science Translational Medicine]
Lo, J. A., Kawakubo, M., Juneja, V. R., Su, M. Y., Erlich, T. H., LaFleur, M. W., Kemeny, L. V., Rashid, M., Malehmir, M., Rabi, S. A., Raghavan, R., Allouche, J., Kasumova, G., Frederick, D. T., Pauken, K. E., Weng, Q. Y., Silva, M. P. da, Xu, Y., Sande, A. A. J. van der, … Fisher, D. E. (2021). Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Science Translational Medicine, 13(581). https://doi.org/10.1126/scitranslmed.abd8636 Cite
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Autophagy Buffers Ras-Induced Genotoxic Stress Enabling Malignant Transformation in Keratinocytes Primed by Human Papillomavirus

Investigators showed that highly transforming mitogenic signals triggered by HRasG12V activity in E6E7–HPV–keratinocytes generated strong replication and oxidative stresses.
[Cell Death & Disease]
Wang, L., Liu, Y., Stratigopoulos, G., Panigrahi, S. K., Sui, L., LeDuc, C. A., Glover, H. J., Rosa, M. C. D., Burnett, L. C., Williams, D. J., Shang, L., Goland, R., Tsang, S. H., Wardlaw, S. L., Egli, D., Zheng, D., Doege, C. A., & Leibel, R. L. (2021). Bardet-Biedl Syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI146287 Cite
Actis Dato, V., Sánchez, M. C., & Chiabrando, G. A. (2021). LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells. Scientific Reports, 11(1), 4742. https://doi.org/10.1038/s41598-021-84090-3 Cite
Ribas, V. T., Vahsen, B. F., Tatenhorst, L., Estrada, V., Dambeck, V., Almeida, R. A., Bähr, M., Michel, U., Koch, J. C., Müller, H. W., & Lingor, P. (2021). AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo. Cell Death & Disease, 12(2), 1–18. https://doi.org/10.1038/s41419-021-03503-3 Cite
Li, Y., Wang, Y., Zhang, W., Wang, X., Chen, L., & Wang, S. (2021). BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. Scientific Reports, 11(1), 4774. https://doi.org/10.1038/s41598-021-82990-y Cite
Log In ‹ Science in Seattle — WordPress. (n.d.). Retrieved February 26, 2021, from https://scienceinseattle.com/wp-login.php?redirect_to=https%3A%2F%2Fscienceinseattle.com%2Fwp-admin%2Fupload.php&reauth=1 Cite
Mukherjee, A., Park, A., Wang, L., & Davies, K. P. (2021). The role of opiorphin genes in prostate cancer growth and progression. Future Oncology. https://doi.org/10.2217/fon-2020-1299 Cite
Aging | Discovery of a novel AR/HDAC6 dual inhibitor for prostate cancer treatment - Full Text. (n.d.). Retrieved February 26, 2021, from https://www.aging-us.com/article/202554/text Cite
Lei, W., Xu, J., Ya, Y., Zhang, J., Hou, X., Zhai, Q., Zha, Z., Zhuo, Y., Zhou, Y., Yuan, H., Liang, Y., Han, Z., Zhong, W., Zhu, L., & Chen, Y. (n.d.). Disulfiram-copper activates chloride currents and induces apoptosis with tyrosine kinase in prostate cancer cells. Asia-Pacific Journal of Clinical Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1111/ajco.13551 Cite
Grayson, K. A., Hope, J. M., Wang, W., Reinhart-King, C. A., & King, M. R. (2021). Taxanes Sensitize Prostate Cancer Cells to TRAIL-Induced Apoptotic Synergy via Endoplasmic Reticulum Stress. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0495 Cite
Schmidt, K. T., Chau, C. H., Strope, J. D., Huitema, A. D. R., Sissung, T. M., Price, D. K., & Figg, W. D. (2021). Anti-tumor activity of NLG207 (formerly CRLX101) in combination with enzalutamide in preclinical prostate cancer models. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0228 Cite
Lee, Y. G., Kim, H. W., Nam, Y., Shin, K. J., Lee, Y. J., Park, D. H., Rhee, H.-W., Seo, J. K., & Chae, Y. C. (2021). LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival. Oncogenesis, 10(2), 1–14. https://doi.org/10.1038/s41389-021-00306-1 Cite
Gregg, J. R., & Thompson, T. C. (2021). Considering the potential for gene-based therapy in prostate cancer. Nature Reviews Urology, 1–15. https://doi.org/10.1038/s41585-021-00431-x Cite
Kuijpers, M., & Haucke, V. (2021). Neuronal autophagy controls the axonal endoplasmic reticulum to regulate neurotransmission in healthy neurons. Autophagy, 0(0), 1–3. https://doi.org/10.1080/15548627.2021.1893569 Cite
Zhu, Y.-M., Lin, L., Wei, C., Guo, Y., Qin, Y., Li, Z.-S., Kent, T. A., McCoy, C. E., Wang, Z.-X., Ni, Y., Zhou, X.-Y., & Zhang, H.-L. (2021). The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke. Translational Stroke Research. https://doi.org/10.1007/s12975-021-00888-3 Cite
Huang, T., Xu, T., Wang, Y., Zhou, Y., Yu, D., Wang, Z., He, L., Chen, Z., Zhang, Y., Davidson, D., Dai, Y., Hang, C., Liu, X., & Yan, C. (2021). Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1885203 Cite
Huang, T., Xu, T., Wang, Y., Zhou, Y., Yu, D., Wang, Z., He, L., Chen, Z., Zhang, Y., Davidson, D., Dai, Y., Hang, C., Liu, X., & Yan, C. (2021). Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1885203 Cite
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell | Journal of the American Chemical Society. (n.d.). Retrieved February 26, 2021, from https://pubs.acs.org/doi/10.1021/jacs.0c12043 Cite
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell | Journal of the American Chemical Society. (n.d.). Retrieved February 26, 2021, from https://pubs.acs.org/doi/10.1021/jacs.0c12043 Cite
Hoshi, S., Meguro, S., Imai, H., Matsuoka, Y., Yoshida, Y., Onagi, A., Tanji, R., Honda‐Takinami, R., Matsuoka, K., Koguchi, T., Hata, J., Sato, Y., Akaihata, H., Kataoka, M., Ogawa, S., & Kojima, Y. (n.d.). Upregulation of glucocorticoid receptor-mediated glucose transporter 4 in enzalutamide-resistant prostate cancer. Cancer Science, n/a(n/a). https://doi.org/https://doi.org/10.1111/cas.14865 Cite
Eskra Jillian N., Rabizadeh Daniel, Zhang Jiayi, Isaacs William B., Luo Jun, & Pavlovich Christian P. (n.d.). Specific Detection of Prostate Cancer Cells in Urine by RNA in Situ Hybridization. Journal of Urology, 0(0), 10.1097/JU.0000000000001691. https://doi.org/10.1097/JU.0000000000001691 Cite
Iqbal, F., Pehar, M., Thompson, A. J., Azeem, U., Jahanbakhsh, K., Jimenez-Tellez, N., Sabouny, R., Batool, S., Syeda, A., Chow, J., Machiraju, P., Shutt, T., Yusuf, K., Shearer, J., Rice, T., & Syed, N. I. (2021). A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly. Scientific Reports, 11(1), 4567. https://doi.org/10.1038/s41598-021-84168-y Cite
Denoth-Lippuner, A., & Jessberger, S. (2021). Formation and integration of new neurons in the adult hippocampus. Nature Reviews Neuroscience, 1–14. https://doi.org/10.1038/s41583-021-00433-z Cite
Yu, R., Longo, J., Leeuwen, J. E. van, Zhang, C., Branchard, E., Elbaz, M., Cescon, D. W., Drake, R. R., Dennis, J. W., & Penn, L. Z. (2021). Mevalonate pathway inhibition slows breast cancer metastasis via reduced N-glycosylation abundance and branching. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2642 Cite
Jones, C. J., Subramaniam, M., Emch, M. J., Bruinsma, E. S., Ingle, J. N., Goetz, M. P., & Hawse, J. R. (2021). Development and characterization of novel endoxifen-resistant breast cancer cell lines highlight numerous differences from tamoxifen-resistant models. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0872 Cite
Ramamoorthi, G., Kodumudi, K., Gallen, C., Zachariah, N. N., Basu, A., Albert, G., Beyer, A., Snyder, C., Wiener, D., Costa, R. L. B., & Czerniecki, B. J. (2021). Disseminated cancer cells in breast cancer: mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2021.02.004 Cite
Liu, T., Hooda, J., Atkinson, J. M., Whiteside, T. L., Oesterreich, S., & Lee, A. V. (2021). Exosomes in breast cancer - Mechanisms of Action and Clinical Potential. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0952 Cite
Broome, R., Chernukhin, I., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., D’Santos, C., Balasubramanian, S., Farcas, A. M., Siersbæk, R., & Carroll, J. S. (2021). TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108776 Cite
Broome, R., Chernukhin, I., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., D’Santos, C., Balasubramanian, S., Farcas, A. M., Siersbæk, R., & Carroll, J. S. (2021). TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108776 Cite
Zhang, Y., Xie, X., Yeganeh, P. N., Lee, D.-J., Valle-Garcia, D., Meza-Sosa, K. F., Junqueira, C., Su, J., Luo, H. R., Hide, W., & Lieberman, J. (2021). Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022830118 Cite
Wigner, P., Zielinski, K., Labieniec-Watala, M., Marczak, A., & Szwed, M. (2021). Doxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Scientific Reports, 11(1), 4544. https://doi.org/10.1038/s41598-021-84146-4 Cite
De Luca, M., Romano, R., & Bucci, C. (2021). Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. Scientific Reports, 11(1), 4615. https://doi.org/10.1038/s41598-021-84222-9 Cite
De Luca, M., Romano, R., & Bucci, C. (2021). Role of the V1G1 subunit of V-ATPase in breast cancer cell migration. Scientific Reports, 11(1), 4615. https://doi.org/10.1038/s41598-021-84222-9 Cite
Wang, M.-Y., Dean, E. D., Quittner-Strom, E., Zhu, Y., Chowdhury, K. H., Zhang, Z., Zhao, S., Li, N., Ye, R., Lee, Y., Zhang, Y., Chen, S., Yu, X., Leonard, D. C., Poffenberger, G., Deylen, A. V., McCorkle, S. K., Schlegel, A., Sloop, K. W., … Holland, W. L. (2021). Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2022142118 Cite
Wu, R., Li, K., Yuan, M., & Luo, K. Q. (2021). Nerve growth factor receptor increases the tumor growth and metastatic potential of triple-negative breast cancer cells. Oncogene, 1–17. https://doi.org/10.1038/s41388-021-01691-y Cite
Rodriguez, E., Boelaars, K., Brown, K., Eveline Li, R. J., Kruijssen, L., Bruijns, S. C. M., van Ee, T., Schetters, S. T. T., Crommentuijn, M. H. W., van der Horst, J. C., van Grieken, N. C. T., van Vliet, S. J., Kazemier, G., Giovannetti, E., Garcia-Vallejo, J. J., & van Kooyk, Y. (2021). Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nature Communications, 12(1), 1270. https://doi.org/10.1038/s41467-021-21550-4 Cite
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021). Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nature Reviews Endocrinology, 1–20. https://doi.org/10.1038/s41574-021-00471-8 Cite
Ávila-López, P. A., Guerrero, G., Nuñez-Martínez, H. N., Peralta-Alvarez, C. A., Hernández-Montes, G., Álvarez-Hilario, L. G., Herrera-Goepfert, R., Albores-Saavedra, J., Villegas-Sepúlveda, N., Cedillo-Barrón, L., Montes-Gómez, A. E., Vargas, M., Schnoor, M., Recillas-Targa, F., & Hernández-Rivas, R. (2021). H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01664-1 Cite
Funato, K., Smith, R. C., Saito, Y., & Tabar, V. (2021). Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.02.003 Cite
Bressan, R. B., Southgate, B., Ferguson, K. M., Blin, C., Grant, V., Alfazema, N., Wills, J. C., Marques-Torrejon, M. A., Morrison, G. M., Ashmore, J., Robertson, F., Williams, C. A. C., Bradley, L., Kriegsheim, A. von, Anderson, R. A., Tomlinson, S. R., & Pollard, S. M. (2021). Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.01.016 Cite
Imtiaz, M. K. bin, Jaeger, B. N., Bottes, S., Machado, R. A. C., Vidmar, M., Moore, D. L., & Jessberger, S. (2021). Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.01.015 Cite
Ghosh, S., Liu, H., Yazdankhah, M., Stepicheva, N., Shang, P., Vaidya, T., Hose, S., Gupta, U., Calderon, M. J., Hu, M.-W., Nair, A. P., Weiss, J., Fitting, C. S., Bhutto, I. A., Gadde, S. G. K., Naik, N. K., Jaydev, C., Lutty, G. A., Handa, J. T., … Sinha, D. (2021). βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity. Communications Biology, 4(1), 1–19. https://doi.org/10.1038/s42003-021-01763-5 Cite
Colombo, A., Dinkel, L., Müller, S. A., Sebastian Monasor, L., Schifferer, M., Cantuti-Castelvetri, L., König, J., Vidatic, L., Bremova-Ertl, T., Lieberman, A. P., Hecimovic, S., Simons, M., Lichtenthaler, S. F., Strupp, M., Schneider, S. A., & Tahirovic, S. (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), 1158. https://doi.org/10.1038/s41467-021-21428-5 Cite
Naskar, S., Qi, J., Pereira, F., Gerfen, C. R., & Lee, S. (2021). Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108774 Cite
Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs: Cell Reports. (n.d.). Retrieved February 24, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00087-5 Cite
Andreassi, C., Luisier, R., Crerar, H., Darsinou, M., Blokzijl-Franke, S., Lenn, T., Luscombe, N. M., Cuda, G., Gaspari, M., Saiardi, A., & Riccio, A. (2021). Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108778 Cite
Hasebe, M., & Shiga, S. (2021). Oviposition-promoting pars intercerebralis neurons show period-dependent photoperiodic changes in their firing activity in the bean bug. Proceedings of the National Academy of Sciences, 118(9). https://doi.org/10.1073/pnas.2018823118 Cite
Suazo, K. F., Jeong, A., Ahmadi, M., Brown, C., Qu, W., Li, L., & Distefano, M. D. (2021). Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells. Scientific Reports, 11(1), 4367. https://doi.org/10.1038/s41598-021-83666-3 Cite
Liu, J. L., Patel, H. D., Haney, N. M., Epstein, J. I., & Partin, A. W. (2021). Advances in the selection of patients with prostate cancer for active surveillance. Nature Reviews Urology, 1–12. https://doi.org/10.1038/s41585-021-00432-w Cite
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation | The EMBO Journal. (n.d.). Retrieved February 23, 2021, from https://www.embopress.org/doi/abs/10.15252/embj.2020106151 Cite
Essaouiba, A., Jellali, R., Shinohara, M., Scheidecker, B., Legallais, C., Sakai, Y., & Leclerc, E. (2021). Analysis of the behavior of 2D monolayers and 3D spheroid human pancreatic beta cells derived from induced pluripotent stem cells in a microfluidic environment. Journal of Biotechnology. https://doi.org/10.1016/j.jbiotec.2021.02.009 Cite
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Improved Diabetic Wound Healing by Bovine Lactoferricin Is Associated with Relevant Changes in the Skin Immune Response and Microbiota

The wound healing potential of bovine lactoferricin was investigated using in vitro, ex vivo, and in vivo models. Cell migration and proliferation were tested on keratinocytes and on porcine ears.
[Molecular Therapy-Methods & Clinical Development]
Mouritzen, M. V., Petkovic, M., Qvist, K., Poulsen, S. S., Alarico, S., Leal, E. C., Dalgaard, L. T., Empadinhas, N., Carvalho, E., & Jenssen, H. (2021). Improved diabetic wound healing by bovine lactoferricin is associated with relevant changes in the skin immune response and microbiota. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.02.008 Cite
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The Effect of Cannabidiol on UV-Induced Changes in Intracellular Signaling of 3D-Cultured Skin Keratinocytes

Scientists analyzed the effect of phytocannabinoid-cannabinoid on the proteome of UVA/B irradiated keratinocytes.
[International Journal of Molecular Sciences]
Gęgotek, A., Atalay, S., Rogowska-Wrzesińska, A., & Skrzydlewska, E. (2021). The Effect of Cannabidiol on UV-Induced Changes in Intracellular Signaling of 3D-Cultured Skin Keratinocytes. International Journal of Molecular Sciences, 22(3), 1501. https://doi.org/10.3390/ijms22031501 Cite
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Fabrication of Hollow Microneedles Using Liquid Crystal Display (LCD) Vat Polymerization 3D Printing Technology for Transdermal Macromolecular Delivery

The authors fabricated a hollow microneedle device consisting of an array and a reservoir by means of 3D printing technology for transdermal peptide delivery. The cytocompatibility of the microneedle arrays was assessed to human keratinocytes.
[International Journal of Pharmaceutics]
Xenikakis, I., Tsongas, K., Tzimtzimis, E. K., Zacharis, C. K., Theodoroula, N., Kalogianni, E. P., Demiri, E., Vizirianakis, I. S., Tzetzis, D., & Fatouros, D. G. (2021). Fabrication of hollow microneedles using liquid crystal display (LCD) vat polymerization 3D printing technology for transdermal macromolecular delivery. International Journal of Pharmaceutics, 120303. https://doi.org/10.1016/j.ijpharm.2021.120303 Cite
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Microfluidic Model with Air-Walls Reveals Fibroblasts and Keratinocytes Modulate Melanoma Cell Phenotype, Migration, and Metabolism

Investigators used a microfluidic platform to evaluate the cross-talk between human primary melanoma cells, keratinocytes and dermal fibroblasts.
[Lab on a Chip]
Ayuso, J. M., Sadangi, S., Lares, M., Rehman, S., Humayun, M., Denecke, K. M., Skala, M. C., Beebe, D. J., & Setaluri, V. (2021). Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism. Lab on a Chip. https://doi.org/10.1039/D0LC00988A Cite
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LncRNA MIR205HG Regulates Melanomagenesis via the miR-299-3p/VEGFA Axis

Researchers demonstrated that lncRNA MIR205HG supports melanoma growth via the miR-299-3p/VEGFA axis.
[Aging]
Aging | LncRNA MIR205HG regulates melanomagenesis via the miR-299-3p/VEGFA axis - Full Text. (n.d.). Retrieved February 5, 2021, from https://www.aging-us.com/article/202450/text Cite
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