A Unique Mode of Keratinocyte Death Requires Intracellular Acidification

Researchers found that upper stratum granulosum cell death was preceded by prolonged (∼60 min) Ca2+ elevation and rapid induction of intracellular acidification.
[Proceedings of the National Academy of Sciences of the United States of America]
Matsui, T., Kadono-Maekubo, N., Suzuki, Y., Furuichi, Y., Shiraga, K., Sasaki, H., Ishida, A., Takahashi, S., Okada, T., Toyooka, K., Sharif, J., Abe, T., Kiyonari, H., Tominaga, M., Miyawaki, A., & Amagai, M. (2021). A unique mode of keratinocyte death requires intracellular acidification. Proceedings of the National Academy of Sciences, 118(17). https://doi.org/10.1073/pnas.2020722118 Cite
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Exploring the Dermotoxicity of the Mycotoxin Deoxynivalenol: Combined Morphologic and Proteomic Profiling of Human Epidermal Cells Reveals Alteration of Lipid Biosynthesis Machinery and Membrane Structural Integrity Relevant for Skin Barrier Function

To investigate the potential dermotoxicity of Deoxynivalenol (DON), epidermoid squamous cell carcinoma cells A431 were compared to primary human neonatal keratinocytes (HEKn) cells via proteome/phosphoproteome profiling.
[Archives of Toxicology]
Del Favero, G., Janker, L., Neuditschko, B., Hohenbichler, J., Kiss, E., Woelflingseder, L., Gerner, C., & Marko, D. (2021). Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. Archives of Toxicology. https://doi.org/10.1007/s00204-021-03042-y Cite
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HucMSC Exosome-Delivered 14-3-3ζ Alleviates Ultraviolet Radiation-Induced Photodamage via SIRT1 Pathway Modulation

To investigate the functions of exosomes derived from human umbilical cord MSC (hucMSC-ex) in a rat model of acute skin photodamage, immunofluorescence and immunohistochemical staining, quantitative real-time-polymerase chain reaction, western blot, and gene silencing assays were performed.
[Aging]
Aging | HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation - Full Text. (n.d.). Retrieved April 23, 2021, from https://www.aging-us.com/article/202851/text Cite
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HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing

The capability of extracellular vesicles (EVs) was leveraged to be engineered via producer cell modification to investigate the therapeutic potential of EVs from mesenchymal stem/stromal cells transfected to overexpress long non‐coding RNA HOX transcript antisense RNA (HOTAIR).
[Advanced Healthcare Materials]
Born, L. J., Chang, K.-H., Shoureshi, P., Lay, F., Bengali, S., Hsu, A. T. W., Abadchi, S. N., Harmon, J. W., & Jay, S. M. (n.d.). HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing. Advanced Healthcare Materials, n/a(n/a), 2002070. https://doi.org/https://doi.org/10.1002/adhm.202002070 Cite
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Nuclear IL-33 Plays an Important Role in the Suppression of Filaggrin, Loricrin, Keratin 1, and Keratin 10 by IL-4 and IL-13 in Human Keratinocytes

Researchers investigated whether intracellular IL-33 is involved in IL-4/IL-13 function. In monolayer-culture and living skin equivalent, IL-4/IL-13 increased the expression of full-length IL-33 in the nucleus of keratinocytes by activating the MEK/ERK signaling pathway, which is necessary for the inhibition of differentiation markers filaggrin, loricrin, keratin1, and keratin 10.
[Journal of Investigative Dermatology]
Dai, X., Utsunomiya, R., Shiraishi, K., Mori, H., Muto, J., Murakami, M., & Sayama, K. (2021). Nuclear IL-33 plays an important role in the suppression of filaggrin, loricrin, keratin 1, and keratin 10 by IL-4 and IL-13 in human keratinocytes. Journal of Investigative Dermatology, 0(0). https://doi.org/10.1016/j.jid.2021.04.002 Cite
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Vitamin D and Lumisterol Derivatives Can Act on Liver X Receptors (LXRs)

Scientists investigated the interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs)
[Scientific Reports]
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Dnmt3a Deficiency in the Skin Causes Focal, Canonical DNA Hypomethylation and a Cellular Proliferation Phenotype

Researchers detected a focal, canonical hypomethylation phenotype that revealed considerable overlap with hypomethylated regions found in Dnmt3a-deficient mouse skin.
[Proceedings of the National Academy of Sciences of the United States of America]
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Activation of Matrix Metalloproteinases and FoxO3a in HaCaT Keratinocytes by Radiofrequency Electromagnetic Field Exposure

The authors evaluated the use and trends of active comparator trial designs in dermatology.
[Scientific Reports]
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Female Immunity Protects from Cutaneous Squamous Cell Carcinoma

Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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Understanding the Cellular Origin and Progression of Esophageal Cancer Using Esophageal Organoids

Patient-derived organoids (PDOs) from human tissue samples allow for unique and faithful in vitro modeling of esophageal cancers, and provide an exciting platform for investigation into personalized medicine and targeted treatment approaches
[Cancer Letters]
Sachdeva, U. M., Shimonosono, M., Flashner, S., Cruz-Acuña, R., Gabre, J. T., & Nakagawa, H. (2021). Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.03.031 Cite
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Bacteria Induce Skin Regeneration via IL-1β Signaling

The Scientists assessed the function of skin bacteria in wound healing and wound-induced hair follicle neogenesis (WIHN), a rare adult organogenesis model.
[Cell Host & Microbe]
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