Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension

The proliferation and fate decisions of basal stem cells are highly regulated by their microenvironment, including the basement membrane and underlying mesenchymal cells. Basal progenitors give rise to differentiated progeny that generate the epidermal barrier. The authors present data that differentiated progeny also regulate the proliferation, differentiation, and migration of basal progenitor cells.
[Cell Stem Cell]
Ning, W., Muroyama, A., Li, H., & Lechler, T. (2020). Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.11.002 Cite
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Functionally Impaired Plasmacytoid Dendritic Cells and Non-Haematopoietic Sources of Type I Interferon Characterize Human Autoimmunity

The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
[Nature Communications]
Psarras, A., Alase, A., Antanaviciute, A., Carr, I. M., Md Yusof, M. Y., Wittmann, M., Emery, P., Tsokos, G. C., & Vital, E. M. (2020). Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity. Nature Communications, 11(1), 6149. https://doi.org/10.1038/s41467-020-19918-z Cite
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Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-Tissue Tension

Using two distinct mouse lines, scientists found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage.
[Cell Stem Cell]
Ning, W., Muroyama, A., Li, H., & Lechler, T. (2020). Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.11.002 Cite
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Endocytic Internalization of Herpes Simplex Virus 1 in Human Keratinocytes at Low Temperature

To address the role of the internalization mode, scientists performed infection studies at low temperature as a tool to interfere with endocytic pathways. Successful Herpes simplex virus-1 entry in primary human keratinocytes and HaCaT cells were observed even at 7°C, although delayed compared to infection at 37°C.
[Journal of Virology]
Cruz, N. D. L., & Knebel-Mörsdorf, D. (2020). Endocytic Internalization of Herpes Simplex Virus 1 in Human Keratinocytes at Low Temperature. Journal of Virology. https://doi.org/10.1128/JVI.02195-20 Cite
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The miR-93-3p/ZFP36L1/ZFX Axis Regulates Keratinocyte Proliferation and Migration during Skin Wound Healing

Scientists demonstrated that miR-93-3p was significantly up-regulated using a in vivo mouse skin wound healing model, there was no change in the expression of miR-93-5p during skin wound healing. In HaCaT cells, miR-93-3p overexpression increased proliferation and migration of the cells, whereas miR-93-3p inhibition had the reverse effect.
[Molecular Therapy-Nucleic Acids]
Feng, X., Zhou, S., Cai, W., & Guo, J. (2020). The miR-93-3p/ZFP36L1/ZFX axis regulates keratinocyte proliferation and migration during skin wound healing. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.11.017 Cite
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A Single-Cell Transcriptomic Atlas of Human Skin Aging

The authors performed single-cell RNA sequencing of human eyelid skin from healthy individuals across different ages and identified 11 canonical cell types, as well as six subpopulations of basal cells.
[Developmental Cell]
Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., Jing, Y., Wang, S., He, Y., Esteban, C. R., Yu, N., Huang, J., Chan, P., Chen, T., Belmonte, J. C. I., Zhang, W., Qu, J., & Liu, G.-H. (2020). A Single-Cell Transcriptomic Atlas of Human Skin Aging. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.11.002 Cite
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Anti-Melanogenesis Effects of Lotus Seedpod In Vitro and In Vivo

Researchers examined the effect of Lotus seedpod extract (LSE) on melanogenesis and the involved signaling pathways in vitro and in vivo. They showed that non-cytotoxic doses of LSE and its main component epigallocatechin reduced both tyrosinase activity and melanin production in the α-melanocyte stimulating hormone-induced melanoma cells.
[Nutrients]
Hsu, J.-Y., Lin, H.-H., Li, T.-S., Tseng, C.-Y., Wong, Y., & Chen, J.-H. (2020). Anti-Melanogenesis Effects of Lotus Seedpod In Vitro and In Vivo. Nutrients, 12(11), 3535. https://doi.org/10.3390/nu12113535 Cite
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Role of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Development of Atopic Dermatitis

Researchers assessed whether 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) affected the development of atopic dermatitis (AD) in vitro and in vivo. The expression of 11β-HSD1 in the epidermis of AD lesions was higher than that in the epidermis of healthy controls.
[Scientific Reports]
Fernández-Calle, R., Galán-Llario, M., Gramage, E., Zapatería, B., Vicente-Rodríguez, M., Zapico, J. M., de Pascual-Teresa, B., Ramos, A., Ramos-Álvarez, M. P., Uribarri, M., Ferrer-Alcón, M., & Herradón, G. (2020). Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Scientific Reports, 10(1), 20259. https://doi.org/10.1038/s41598-020-76415-5 Cite
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The Unfolded Protein and Integrated Stress Response in Melanoma and Vitiligo

Investigators review the potential roles of the unfolded protein response/integrated stress response in the etiology of melanoma and vitiligo.
[Pigment Cell & Melanoma Research]
Manga, P., & Choudhury, N. (n.d.). The Unfolded Protein and Integrated Stress Response in Melanoma and Vitiligo. Pigment Cell & Melanoma Research, n/a(n/a). https://doi.org/https://doi.org/10.1111/pcmr.12947 Cite
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A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue

Scientists analyze four major signaling pathways implicated in melanomagenesis, TGF-β, MAPK, Wnt/β-catenin and Hyppo signaling, from the complementary point of view of tumor cells and the microenvironment.
[Cancers]
Bellei, B., Migliano, E., & Picardo, M. (2020). A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue. Cancers, 12(11), 3400. https://doi.org/10.3390/cancers12113400 Cite
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Boesenbergia rotunda Extract Accelerates Human Keratinocyte Proliferation through Activating ERK1/2 and PI3K/Akt Kinases

As a step towards the development of wound healing agents, scientists utilized a human keratinocyte cell line as an in vitro model to define the potential molecular mechanisms of Boesenbergia rotunda extract in enhancing wound-healing.
[Biomedicine & Pharmacotherapy]
Boesenbergia rotunda extract accelerates human keratinocyte proliferation through activating ERK1/2 and PI3K/Akt kinases - ScienceDirect. (n.d.). Retrieved November 20, 2020, from https://www.sciencedirect.com/science/article/pii/S075333222031194X?via%3Dihub Cite
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