The Application of Mesenchymal Stromal Cells (MSCs) and Their Derivative Exosome in Skin Wound Healing: A Comprehensive Review

Scientists overview recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.
[Stem Cell Research & Therapy]
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Trehangelins Ameliorate Inflammation-Induced Skin Senescence by Suppressing the Epidermal YAP-CCN1 Axis

Researchers described a possible mechanism involved in skin aging focusing on the effect of Trehangelins on epidermal cellular communication metwork factor 1 (CCN1).
[Scientific Reports]
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Discrimination of Hand-Foot Skin Reaction Caused by Tyrosine Kinase Inhibitors Based on Direct Keratinocyte Toxicity and Vascular Endothelial Growth Factor Receptor-2 Inhibition

The authors explained the incidence of hand-foot skin reaction in patients treated with tyrosine kinase inhibitors by focusing on keratinocyte toxicity and inhibition of vascular endothelial growth factor receptor, which played an essential role in angiogenesis.
[Biochemical Pharmacology]
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Reduced Expression of Collagen 17A1 in Naturally Aged, Photoaged, and UV-Irradiated Human Skin In Vivo: Potential Links to Epidermal Aging

Researchers found that matrix metalloproteinases were responsible for ultraviolet (UV)-mediated Collagen 17A degradation in both in vitro keratinocytes and in vivo mouse skin.
[Journal of Cell Communication and Signaling]
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TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes

Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology]
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Advances in the Pathogenesis of Psoriasis: From Keratinocyte Perspective

The authors review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions.
[Cell Death & Disease]
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Coordinated Post-Transcriptional Control of Oncogene-Induced Senescence by UNR/CSDE1

Researchers showed that the RNA-binding protein UNR/CSDE1 enabled oncogene-induced senescence in primary mouse keratinocytes.
[Cell Reports]
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Protooncogene MYC Drives Human Melanocyte Melanogenesis and Senescence

Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.
[Cancer Gene Therapy]
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Regeneration of Collagen Fibrils at the Papillary Dermis by Reconstructing Basement Membrane at the Dermal–Epidermal Junction

Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
[Scientific Reports]
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Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis

Researchers evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.
[Inflammation]
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Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.
[Journal of Cellular and Molecular Medicine]
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