The Flavonoid Nobiletin Exhibits Differential Effects on Cell Viability in Keratinocytes Exposed to UVA versus UVB Radiation

Though nobiletin limited UVB-irradiated human keratinocytes from undergoing cell death, researchers found that this enhanced survival was not associated with increased nucleotide excision repair or XPA expression. Instead, nobiletin reduced initial UV photoproduct formation and promoted a G1 cell cycle arrest.