TWEAK Functions with TNF and IL-17 on Keratinocytes and Is a Potential Target for Psoriasis Therapy

Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.