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keratinocytes

Biosafety and Differentially Expressed Genes Analysis of Melanoma Cells Treated with Cold Atmospheric Plasma

[Journal of Biophotonics] Researchers evaluated cell viability, apoptosis rate, and reactive species injection efficiency of melanoma cells and human keratinocyte cells treated with cold atmospheric plasma and analyzed its biological safety.

MiR-378a Regulates Keratinocyte Responsiveness to IL-17A in Psoriasis

[British Journal of Dermatology] Investigators showed that microRNA-378a (miR-378a) was induced by IL-17A in keratinocytes through NF-κB, C/EBP-β and IκBζ, and was overexpressed in psoriasis epidermis.

Restriction of Viral Gene Expression and Replication Prevents Immortalization of Human Keratinocytes by a Beta-Human Papillomavirus

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that the beta-human papillomavirus 49 wild-type genome was transcriptionally active in normal human keratinocytes but lacked immortalizing activity unless the E8 gene was inactivated.

In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis

[Frontiers in Bioengineering and Biotechnology] Investigators summarize the key features of psoriasis and atopic dermatitis, the different types of in vitro models available to study their pathophysiology and evaluate their efficacy in addition to discussing future research opportunities.

Antagonism of the Transient Receptor Potential Melastatin-2 Channel Leads to Targeted Antitumor Effects in Primary Human Malignant Melanoma Cells

[International Journal of Oncology] Researchers determined the effects of antagonism of the transient receptor potential melastatin‑2 ion channel in primary human malignant melanoma cells.

LncRNA XIST Engages in Psoriasis via Sponging MiR-338-5p to Regulate Keratinocyte Proliferation and Inflammation

[Skin Pharmacology and Physiology] Scientists investigated the role and regulatory relationship between long noncoding RNA (lncRNA) XIST and miR-338-5p in psoriatic patients and cell models.

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