keratinocytes

[Inflammation] Researchers evaluated galectin (Gal)-1 and Gal-3 levels, which are beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.

[Journal of Cellular and Molecular Medicine] Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.

[Biochemical and Biophysical Research Communications] The authors demonstrated that the ablation of vitamin D receptor in keratinocytes greatly exacerbated dermal fibrosis in HOCl-induced scleroderma in mice.

[Theranostics] Researchers reported on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing vascular endothelial growth factor (VEGF) A in keratinocytes by means of large-scale optoacoustic microscopy.

[Experimental Dermatology] In the skin, UV-irradiation increases expression of matrix metalloproteinases (MMPs) that causes dysregulation of extracellular matrix homeostasis in dermis, leading to acceleration of skin aging. Researchers reported the role of transglutaminase 2 in mediating the UVB-induced expression of MMP-1.

[Stem Cell Research & Therapy] Scientists summarize on the recent findings concerning the application of MSCs and their derivative exosome to support wound healing and skin regeneration, with special focus on last decade in vivo reports.