leukemia

[Cell Death & Disease] The authors revealed that the BC200/miR-150-5p/MYB positive feedback loop promoted the proliferation of myelodysplastic syndrome (MDS) cells and was expected to be a potential biomarker and therapeutic target in MDS.

[Nature Genetics] Through targeted sequencing in 5,008 patients, investigators identified a key regulatory germline variant in GATA3 associated with Philadelphia chromosome-like acute lymphoblastic leukemia.

[Molecular and Cellular Biochemistry] Scientists focus on the pharmacokinetics of approved tyrosine kinase inhibitors related to chronic myeloid leukemia (CML) therapy to comprehend their specificity, tolerability, and off-target effects, which could help clinicians to make a patient-specific selection of CML drugs by considering concomitant diseases and risk factors to the patients.

[Haematologica] Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.

[Haematologica] Researchers developed a CD38 CAR-NK cell therapy for acute myeloid leukemia, first by using an NK cell line which had low baseline CD38 expression and subsequently NK cells expanded from healthy donors.

[Blood Cancer Journal] An RT-MPLA assay was applied to a consecutive series of 522 adult and pediatric T cell acute lymphoblastic leukemias and identified a fusion transcript in 20% of cases.