leukemia

[Nature Communications] Scientists identified Quinacrine (QC) as a sensitizer for Cytarabine (AraC) in treating acute lymphoblastic leukemia (ALL) and showed that QC enhanced AraC-mediated killing of ALL cells, and subsequently abrogated AraC resistance both in vitro and in an ALL-xenograft model.

[Cell Reports] To gain a deeper understanding of the molecular characteristics associated with CAR T cell differentiation, researchers performed longitudinal genome-wide DNA methylation profiling of CD8+ CD19-CAR T cells post-infusion in acute lymphoblastic leukemia patients.

[Cancer Research] The authors analyzed whole-exome sequencing data from 1,958 lung cancer cases and controls. Potential clonal hematopoiesis mutations were identified by a set of hierarchical filtering criteria in different exonic regions.

[PLoS One] Scientists revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in Hodgkin lymphoma which promoted hallmark aberrations of this disease.

[Leukemia] Researchers reported the development of an acute myeloid leukemia cell membrane-coated nanoparticle vaccine platform, in which immune-stimulatory adjuvant-loaded nanoparticles were coated with leukemic cell membrane material.

[Leukemia Research] Scientists discuss in detail the mechanisms involved in accumulation of cadmium in particular cell lines of the bone marrow and the consequent occurrence of acute myeloid leukemia.