leukemia

[Experimental Cell Research] The authors found that lipid transport-associated genes were upregulated in the high interleukin-6 (IL-6) receptor expression group. IL-6 promoted fatty acid uptake in both AML cell lines and primary AML cells.

[Biochemical Pharmacology] Investigators proposed a mechanism by which hydroquinone induced the malignant progression of chronic myeloid leukemia cells.

[Clinical Cancer Research] The combination of crenolanib and sorafenib was tolerable with antileukemic activities and rare emergence of FLT3-TKD mutations, which warrants further investigation.

[Frontiers in Immunology] Scientists examine the immunosuppressive features of the leukemia microenvironment, discuss how preclinical modeling help predict adoptive cell therapy (ACT) associated toxicities and dysfunction, and explore publications that have employed syngeneic modeling in ACT studies for the improvement of therapy for leukemias.

[Experimental Hematology & Oncology] Preclinical investigation of the CD22 CAR-T therapy against B cell malignancies was evaluated by co-culturing CD22 CAR-T cells with tumor cell lines or primary blasts from patients in vitro and using a xenograft mouse model in vivo.

[Journal of Cellular Physiology] Scientists summarize the potential miRNAs, especially circulating ones, involved in essential signaling pathways in the acute lymphocytic leukemia and chronic lymphocytic leukemia patients which serve as biomarkers and valuable targets in the treatment fields.