Histone Demethylase JMJD2D Promotes the Self-Renewal of Liver Cancer Stem-Like Cells by Enhancing EpCAM and Sox9 Expression

Investigators showed that histone lysine demethylase 4D (JMJD2D) expression was increased in liver cancer stem-like cells (LCSCs); downregulation of JMJD2D inhibited the self-renewal of LCSCs in vitro and in vivo and inhibited the lung metastasis of LCSCs by reducing the survival and the early lung seeding of circulating LCSCs.
[Journal of Biological Chemistry]
Deng, Y., Li, M., Zhuo, M., Guo, P., Chen, Q., Mo, P., Li, W., & Yu, C. (2020). Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. Journal of Biological Chemistry, jbc.RA120.015335. https://doi.org/10.1074/jbc.RA120.015335 Cite
AbstractFull Article
Bookmark

No account yet? Register

0
Share

PIDDosome-Induced p53-Dependent Ploidy Restriction Facilitates Hepatocarcinogenesis

PIDDosome deficiency reduced tumor number and burden, despite the inability to activate p53 in polyploid cells. Liver tumors arose primarily from cells with low ploidy, indicating an intrinsic pro‐tumorigenic effect of PIDDosome‐mediated ploidy restriction.
[EMBO Reports]
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N., & Villunger, A. (2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports, n/a(n/a), e50893. https://doi.org/10.15252/embr.202050893 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Immunobiology and Immunotherapy of HCC: Spotlight on Innate and Innate-Like Immune Cells

Investigators summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them. They also discuss current immunotherapeutic strategies in hepatocellular carcinoma and outline recent advances in our understanding of how the therapeutic potential of these agents might be enhanced.
[Cellular & Molecular Immunology]
Ruf, B., Heinrich, B., & Greten, T. F. (2020). Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Cellular & Molecular Immunology, 1–16. https://doi.org/10.1038/s41423-020-00572-w Cite
Abstract
Bookmark

No account yet? Register

0
Share

Reciprocal REGγ-mTORC1 Regulation Promotes Glycolytic Metabolism in Hepatocellular Carcinoma

Ablation of REGγ increased the stability of protein phosphatase 2 catalytic subunit in vitro and in vivo, which dephosphorylated AKT1 substrate 1 and stabilized the interaction between PRAS40 and Raptor to inactive mTORC1-mediated hyper-glycolytic metabolism.
[Oncogene]
Yao, L., Xuan, Y., Zhang, H., Yang, B., Ma, X., Wang, T., Meng, T., Sun, W., Wei, H., Ma, X., Moses, R., Xiao, J., Zhang, P., Ge, C., Li, J., Li, L., Li, X., Li, J., & Zhang, B. (2020). Reciprocal REGγ-mTORC1 regulation promotes glycolytic metabolism in hepatocellular carcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01558-8 Cite
Abstract
Bookmark

No account yet? Register

0
Share

CYP2C8 Regulated by GAS5/miR-382-3p Exerts Anti-Cancerous Properties in Liver Cancer

Lower levels of P450 family 2 subfamily C member 8 (CYP2C8) were confirmed in liver cancer cells. CYP2C8 overexpression efficiently attenuated liver cancer cell proliferation and promoted apoptosis.
[Cancer Biology & Therapy]
Li, K., & Chen, Y. (2020). CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer. Cancer Biology & Therapy, 0(0), 1–9. https://doi.org/10.1080/15384047.2020.1840886 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer

Researchers showed by genetic lineage tracing that PROM1+ cells were derived in part from hepatocytes in alcoholic hepatitis and became tumor cells in mice with diethyl nitrosamine-initiated, Western alcohol diet-promoted liver tumorigenesis.
[Scientific Reports]
Wu, R., Pan, S., Chen, Y., Nakano, Y., Li, M., Balog, S., & Tsukamoto, H. (2020). Fate and functional roles of Prominin 1 + cells in liver injury and cancer. Scientific Reports, 10(1), 19412. https://doi.org/10.1038/s41598-020-76458-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Surface Oncology Announces FDA Fast Track Designation Granted by US Food and Drug Administration for SRF388 to Treat Liver Cancer

Surface Oncology develop next-generation immunotherapies that target the tumor microenvironment. They have announced that the US FDA has granted Fast Track designation to SRF388 for the treatment of patients with hepatocellular carcinoma, or liver cancer, who have been previously treated with standard therapies, such as vascular endothelial growth factor targeted agents and programmed death-ligand blockade.
[Surface Oncology]
Press Release
Bookmark

No account yet? Register

0
Share

Neutrophils in Liver Diseases: Pathogenesis and Therapeutic Targets

Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Accordingly, this review summarizes the role of neutrophils in liver diseases.
[Cellular & Molecular Immunology]
Liu, K., Wang, F.-S., & Xu, R. (2020). Neutrophils in liver diseases: pathogenesis and therapeutic targets. Cellular & Molecular Immunology, 1–7. https://doi.org/10.1038/s41423-020-00560-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Cabozantinib-Based Combination Therapy for the Treatment of Hepatocellular Carcinoma

Human hepatocellular carcinoma (HCC) cell lines and HCC mouse models were used to assess the therapeutic efficacy and targeted molecular pathways of cabozantinib, either alone or in combination with the pan-mTOR inhibitor MLN0128 or the checkpoint inhibitor anti-PD-L1 antibody.
[Gut]
Shang, R., Song, X., Wang, P., Zhou, Y., Lu, X., Wang, J., Xu, M., Chen, X., Utpatel, K., Che, L., Liang, B., Cigliano, A., Evert, M., Calvisi, D. F., & Chen, X. (2020). Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma. Gut. https://doi.org/10.1136/gutjnl-2020-320716 Cite
Abstract
Bookmark

No account yet? Register

0
Share

The Impact of Endotrophin on the Progression of Chronic Liver Disease

The fibrotic liver is characterized by the pathological accumulation of ECM proteins. Type VI collagen alpha3 is a biomarker of hepatic fibrosis, and its cleaved form, endotrophin (ETP), plays a critical role in adipose tissue dysfunction, insulin resistance, and breast cancer development. Scientists studied the effects of the Col6a3-derived peptide ETP on the progression of chronic liver diseases, such as NASH and liver cancer.
[Experimental and Molecular Medicine]
Kim, M., Lee, C., Seo, D. Y., Lee, H., Horton, J. D., Park, J., & Scherer, P. E. (2020). The impact of endotrophin on the progression of chronic liver disease. Experimental & Molecular Medicine, 1–11. https://doi.org/10.1038/s12276-020-00520-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

EAG1 Enhances Hepatocellular Carcinoma Proliferation by Modulating SKP2 and Metastasis through Pseudopod Formation

Scientists verified that Ether-à-go-go-1 (EAG1) promoted the proliferation of hepatocellular carcinoma both in vitro and in vivo. It promoted cell cycle progression by inhibiting the ubiquitination of SKP2.
[Oncogene]
Chen, J., Xuan, Z., Song, W., Han, W., Chen, H., Du, Y., Xie, H., Zhao, Y., Zheng, S., & Song, P. (2020). EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01522-6 Cite
Abstract
Bookmark

No account yet? Register

0
Share
Share