A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

Resaearchers uncovered a TNFR2-hnRNPK-YAP signaling axis in hepatic progenitor cells essential for primary liver cancer development.
[Cancer Research]
Meng, Y., Zhao, Q., An, L., Jiao, S., Li, R., Sang, Y., Liao, J., Nie, P., Wen, F., Ju, J., Zhou, Z., & Wei, L. (2021). A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3175 Cite
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C2orf40 Inhibits Hepatocellular Carcinoma through UBR5-Dependent or p53-Independent Mechanisms

The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology]
Wu, Y., Xiang, Q., Lv, X., Xiang, X., Feng, Z., Tian, S., Tang, J., Xiang, T., & Gong, J. (n.d.). C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms. Journal of Gastroenterology and Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/jgh.15441 Cite
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Lactonic Sophorolipid–Induced Apoptosis in Human HepG2 Cells through the Caspase-3 Pathway

The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology]
Wang, X., Xu, N., Li, Q., Chen, S., Cheng, H., Yang, M., Jiang, T., Chu, J., Ma, X., & Yin, D. (2021). Lactonic sophorolipid–induced apoptosis in human HepG2 cells through the Caspase-3 pathway. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-020-11045-5 Cite
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Overexpression of Ring Finger Protein 20 Inhibits the Progression of Liver Fibrosis via Mediation of Histone H2B Lysine 120 Ubiquitination

To mimic liver fibrosis in vitro, LX-2 cells were treated with TGF-β. Gene and protein expressions were detected by RT-qPCR and western blot, respectively.
[Human Cell]
Chen, S., Dai, X., Li, H., Gong, Y., Zhao, Y., & Huang, H. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. Human Cell. https://doi.org/10.1007/s13577-021-00498-z Cite
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Stress Kinases in the Development of Liver Steatosis and Hepatocellular Carcinoma

The authors summarize findings indicating that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players inducing liver fibrosis.
[Molecular Metabolism]
Cicuéndez, B., Ruiz-Garrido, I., Mora, A., & Sabio, G. (2021). Stress kinases in the development of liver steatosis and hepatocellular carcinoma. Molecular Metabolism, 101190. https://doi.org/10.1016/j.molmet.2021.101190 Cite
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Gene Expression Profiles of Liver Cancer Cell Lines Reveal Two Hepatocyte-Like and Fibroblast-Like Clusters

The authors investigated the characteristics of liver cancer cell lines by analyzing the gene expression data available in the Cancer Cell Line Encyclopedia. Unsupervised clustering analysis of 28 liver cancer cell lines yielded two main clusters.
[PLoS One]
Fukuyama, K., Asagiri, M., Sugimoto, M., Tsushima, H., Seo, S., Taura, K., Uemoto, S., & Iwaisako, K. (2021). Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters. PLOS ONE, 16(2), e0245939. https://doi.org/10.1371/journal.pone.0245939 Cite
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Microvesicles Mediate Sorafenib Resistance in Liver Cancer Cells through Attenuating p53 and Enhancing FOXM1 Expression

Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
[Life Sciences]
Jaffar Ali, D., He, C., Xu, H., Kumaravel, S., Sun, B., Zhou, Y., Liu, R., & Xiao, Z. (2021). Microvesicles mediate sorafenib resistance in liver cancer cells through attenuating p53 and enhancing FOXM1 expression. Life Sciences, 271, 119149. https://doi.org/10.1016/j.lfs.2021.119149 Cite
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The Role of Farnesoid X Receptor in Metabolic Diseases, and Gastrointestinal and Liver Cancer

Studies on the role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer are discussed, and the potential for development of targeted drugs are summarized.
[Nature Reviews Gastroenterology & Hepatology]
Sun, L., Cai, J., & Gonzalez, F. J. (2021). The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer. Nature Reviews Gastroenterology & Hepatology, 1–13. https://doi.org/10.1038/s41575-020-00404-2 Cite
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Mitochondrial Oxidative Metabolism Contributes to a Cancer Stem Cell Phenotype in Cholangiocarcinoma

Investigators analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stem state in cholangiocarcinoma.
[Journal of Hepatology]
Raggi, C., Taddei, M. L., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Campani, C., Pranzini, E., Iorio, J., Lori, G., Lottini, T., Peano, C., Cibella, J., Lewinska, M., Andersen, J. B., Tommaso, L. di, Vigano, L., Maira, G. D., … Marra, F. (2021). Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma. Journal of Hepatology, 0(0). https://doi.org/10.1016/j.jhep.2020.12.031 Cite
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EMT-Associated MicroRNAs and Their Roles in Cancer Stemness and Drug Resistance

Scientists preliminarily looked into the various roles that the epithelial-to-mesenchymal transition‐associated microRNAs play in the stem‐like nature of malignant cells.
[Cancer Communications]
Pan, G., Liu, Y., Shang, L., Zhou, F., & Yang, S. (n.d.). EMT-associated microRNAs and their roles in cancer stemness and drug resistance. Cancer Communications, n/a(n/a). https://doi.org/https://doi.org/10.1002/cac2.12138 Cite
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Recent Updates on Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma

The authors summarize current chimeric antigen receptor T cell (CAR-T) therapy targets in the treatment of hepatocellular carcinoma (HCC), discuss current obstacles and possible solutions in the process, and describe potential strategies to improve the efficacy of CAR-T cells for patients with HCC.
[Cancer Gene Therapy]
Guo, J., & Tang, Q. (2021). Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma. Cancer Gene Therapy, 1–13. https://doi.org/10.1038/s41417-020-00259-4 Cite
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