Resaearchers uncovered a TNFR2-hnRNPK-YAP signaling axis in hepatic progenitor cells essential for primary liver cancer development.
6445212 7U58FK63 items 1 apa default asc 1
Meng, Y., Zhao, Q., An, L., Jiao, S., Li, R., Sang, Y., Liao, J., Nie, P., Wen, F., Ju, J., Zhou, Z., & Wei, L. (2021). A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3175 Cite
The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology]
6445212 GA4IA3WH items 1 apa default asc 1
Wu, Y., Xiang, Q., Lv, X., Xiang, X., Feng, Z., Tian, S., Tang, J., Xiang, T., & Gong, J. (n.d.). C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms. Journal of Gastroenterology and Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/jgh.15441 Cite
The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology]
6445212 BEUFM4VB items 1 apa default asc 1
To mimic liver fibrosis in vitro, LX-2 cells were treated with TGF-β. Gene and protein expressions were detected by RT-qPCR and western blot, respectively.
6445212 SX25H9EX items 1 apa default asc 1
The authors summarize findings indicating that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players inducing liver fibrosis.
The authors investigated the characteristics of liver cancer cell lines by analyzing the gene expression data available in the Cancer Cell Line Encyclopedia. Unsupervised clustering analysis of 28 liver cancer cell lines yielded two main clusters.
6445212 B5R5SY4E items 1 apa default asc 1
Investigators report the effects of liver cancer cell-secreted microvesicles on sorafenib resistance in liver cancer cells HepG2 and Huh7 both in vitro and in vivo.
6445212 VSXRXFZJ items 1 apa default asc 1
Studies on the role of farnesoid X receptor in metabolic diseases and gastrointestinal and liver cancer are discussed, and the potential for development of targeted drugs are summarized.
[Nature Reviews Gastroenterology & Hepatology]
Investigators analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stem state in cholangiocarcinoma.
[Journal of Hepatology]
6445212 JXS5Z5IL items 1 apa default asc 1
Raggi, C., Taddei, M. L., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Campani, C., Pranzini, E., Iorio, J., Lori, G., Lottini, T., Peano, C., Cibella, J., Lewinska, M., Andersen, J. B., Tommaso, L. di, Vigano, L., Maira, G. D., … Marra, F. (2021). Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma. Journal of Hepatology, 0(0). https://doi.org/10.1016/j.jhep.2020.12.031 Cite
Scientists preliminarily looked into the various roles that the epithelial-to-mesenchymal transition‐associated microRNAs play in the stem‐like nature of malignant cells.
6445212 6FCSAMNC items 1 apa default asc 1
Pan, G., Liu, Y., Shang, L., Zhou, F., & Yang, S. (n.d.). EMT-associated microRNAs and their roles in cancer stemness and drug resistance. Cancer Communications, n/a(n/a). https://doi.org/https://doi.org/10.1002/cac2.12138 Cite
The authors summarize current chimeric antigen receptor T cell (CAR-T) therapy targets in the treatment of hepatocellular carcinoma (HCC), discuss current obstacles and possible solutions in the process, and describe potential strategies to improve the efficacy of CAR-T cells for patients with HCC.
[Cancer Gene Therapy]