The Therapeutic Landscape of Hepatocellular Carcinoma

Scientists shed light into the current therapeutic landscape of hepatocellular carcinoma with an emphasis on the available treatments, ranging from surgical and local-ablative therapy for early and intermediate stages of the disease to systemic therapies for advanced cancer treatments.
[Med]
Gallage, S., García-Beccaria, M., Szydlowska, M., Rahbari, M., Mohr, R., Tacke, F., & Heikenwalder, M. (2021). The therapeutic landscape of hepatocellular carcinoma. Med, 0(0). https://doi.org/10.1016/j.medj.2021.03.002 Cite
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Microvesicles – Promising Tiny Players’ of Cancer Stem Cells Targeted Liver Cancer Treatments: The Interesting Interactions and Therapeutic Aspects

The authors summarize the existing evidence that supports the concept of microvesicles, the tiny particles have a big role behind the rare immortal cancer stem cells which controls the tumor initiation, propagation and metastasis in liver cancer.
[Pharmacological Research]
He, C., Ali, D. J., Aseervatham G, S. B., Sun, B., & Xiao, Z. (2021). Microvesicles – promising tiny players’ of cancer stem cells targeted liver cancer treatments: the interesting interactions and therapeutic aspects. Pharmacological Research, 105609. https://doi.org/10.1016/j.phrs.2021.105609 Cite
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Co-encapsulation of Collagenase Type I and Silibinin in Chondroitin Sulfate Coated Multilayered Nanoparticles for Targeted Treatment of Liver Fibrosis

Investigators demonstrated that chondroitin sulfate coated multilayered 50-nm nanoparticles encapsulating collagenase and silibinin broke down the dense collagen stroma, while silibinin inhibited activated hepatic stellate cells.
[Carbohydrate Polymers]
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Restitution of Epithelial Cells during Intestinal Mucosal Wound Healing: The Effect of a Polysaccharide from the Sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden

Researchers investigated the effect and mechanism of β-glucan prepared from Lignosus rhinocerotis using an enzymatic method on epithelial restitution during intestinal mucosal damage.
[Journal of Ethnopharmacology]
Veeraperumal, S., Qiu, H.-M., Tan, C.-S., Ng, S.-T., Zhang, W., Tang, S., Cheong, K.-L., & Liu, Y. (2021). Restitution of epithelial cells during intestinal mucosal wound healing: the effect of a polysaccharide from the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden. Journal of Ethnopharmacology, 114024. https://doi.org/10.1016/j.jep.2021.114024 Cite
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Fat Induces Glucose Metabolism in Non-Transformed Liver Cells and Promotes Liver Tumorigenesis

Scientists suggested that fat can induce glucose-mediated metabolic changes in non-transformed liver cells similar to those found in hepatocellular carcinoma.
[Cancer Research]
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New Positive Data from Can-Fite’s Liver Cancer Phase II Clinical Study with Namodenoson

Can-Fite BioPharma Ltd. announced new data from the Phase II advanced liver cancer study including overall survival of nearly 4 years in two patients who are under namodenoson treatment.
[Can-Fite BioPharma Ltd.]
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A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

Researchers uncovered a TNFR2-hnRNPK-YAP signaling axis in hepatic progenitor cells essential for primary liver cancer development.
[Cancer Research]
Meng, Y., Zhao, Q., An, L., Jiao, S., Li, R., Sang, Y., Liao, J., Nie, P., Wen, F., Ju, J., Zhou, Z., & Wei, L. (2021). A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-3175 Cite
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C2orf40 Inhibits Hepatocellular Carcinoma through UBR5-Dependent or p53-Independent Mechanisms

The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology]
Wu, Y., Xiang, Q., Lv, X., Xiang, X., Feng, Z., Tian, S., Tang, J., Xiang, T., & Gong, J. (n.d.). C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms. Journal of Gastroenterology and Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/jgh.15441 Cite
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Lactonic Sophorolipid–Induced Apoptosis in Human HepG2 Cells through the Caspase-3 Pathway

The effects of lactonic sophorolipids and cell death inhibitors were measured by MTT test on HepG2 cells. Their morphology of the cells was observed under a microscope.
[Applied Microbiology and Biotechnology]
Wang, X., Xu, N., Li, Q., Chen, S., Cheng, H., Yang, M., Jiang, T., Chu, J., Ma, X., & Yin, D. (2021). Lactonic sophorolipid–induced apoptosis in human HepG2 cells through the Caspase-3 pathway. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-020-11045-5 Cite
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Overexpression of Ring Finger Protein 20 Inhibits the Progression of Liver Fibrosis via Mediation of Histone H2B Lysine 120 Ubiquitination

To mimic liver fibrosis in vitro, LX-2 cells were treated with TGF-β. Gene and protein expressions were detected by RT-qPCR and western blot, respectively.
[Human Cell]
Chen, S., Dai, X., Li, H., Gong, Y., Zhao, Y., & Huang, H. (2021). Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination. Human Cell. https://doi.org/10.1007/s13577-021-00498-z Cite
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Stress Kinases in the Development of Liver Steatosis and Hepatocellular Carcinoma

The authors summarize findings indicating that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players inducing liver fibrosis.
[Molecular Metabolism]
Cicuéndez, B., Ruiz-Garrido, I., Mora, A., & Sabio, G. (2021). Stress kinases in the development of liver steatosis and hepatocellular carcinoma. Molecular Metabolism, 101190. https://doi.org/10.1016/j.molmet.2021.101190 Cite
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