liver cancer

[Journal of Experimental & Clinical Cancer Research] The authors discuss the epigenetic landscape in hepatocarcinogenesis, including evidence on the diagnostic and prognostic role of non-coding RNAs, modifications occurring at the chromatin level, and their role in the era of precision medicine.

[Cancer Research] Investigators identified DHX37 as one of the top RNA helicase genes with upregulated expression in HCC. DHX37 promoted proliferation of liver cancer cells in vitro and in vivo.

[Carcinogenesis] Scientists review the evolution of tools to evaluate CSCs in liver cancers, discuss their contributions and limitations, as well as their combined and complementary utilization with techniques like human tumor organoid culture.

[Scientific Reports] Scientists utilized the strategy of iterative gene pairing to construct a tumor-specific immune-related lincRNA pairs signature, which did not require specific expression levels, as an indicator of patient outcomes.

[Molecular Cancer] Whole-genome sequencing revealed that circ-ZEB1 and PIK3CA were highly expressed in HCC tissues, whereas miR-199a-3p was significantly downregulated in HCC.

[Cancer Research] Researchers explored the potential of antisense oligonucleotides (ASO)-based pyruvate kinase (PKM) splice switching as a targeted therapy for liver cancer. A more potent lead constrained-ethyl/DNA ASO induced PKM splice switching and inhibited the growth of cultured HCC cells.