liver fibrosis

[Stem Cell Research & Therapy] The authors established mouse models of CCl4-injured liver fibrosis (LF) and administered hPMSCs at different stages of LF once a week for two weeks. The therapeutic effect of hPMSCs on LF was investigated, according to histopathological and blood biochemical analyses.

[Cancer Letters] In hepatocellular carcinoma patients, low FIB-4 values and high CD8+ T cell infiltration were correlated with prolonged survival.

[Cell Death & Disease] Researchers investigated the Fas/FasL signaling and hepatocytes apoptosis in liver samples from both human sections and mouse models.

[Nature Reviews Gastroenterology & Hepatology] The authors describe the evidence of an association and causal link between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), discusses the putative pathophysiological mechanisms linking NAFLD to T2DM and summarizes the current pharmacological treatments for NAFLD or T2DM that might benefit or adversely affect the risk of T2DM or NAFLD progression.

[Cell Death & Disease] Investigators found that glucocorticoid-induced leucine zipper deficiency in mice was associated with elevated CCL2 production and pro-inflammatory leukocyte infiltration at the early liver fibrosis (LF) stage, resulting in enhanced LF development.

[Hepatology] After hepatic differentiation, NASH liver organoids exhibited reduced ability to dedifferentiate back to the biliary state, consistent with the known reduced regenerative ability of NASH livers.