liver fibrosis

[Cell Death Discovery] Researchers investigated the molecular mechanisms underlying the effect of berberine against liver fibrogenesis in thioacetamide and carbon tetrachloride induced mouse liver fibrosis.

[Cell Death & Disease] Scientists found that inhibition of monocyte-derived macrophages (MoMFs) SYK impaired the expression of CXCL1, reduced the recruitment of inflammatory cells, and promoted the phenotype cross-dress process of pro-resolution MoMFs, thereby remodeling the chronic inflammatory environment of the fibrotic liver.

[Cell Death & Disease] Scientists identified transcriptional programs of initiating and activated hepatic stellate cells by RNA sequencing, using in vitro and in vivo mouse models of fibrosis.

[Cell Proliferation] Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.

[CytoDyn, Inc.] CytoDyn Inc., a late-stage biotechnology company developing leronlimab, a CCR5 antagonist with the potential for multiple therapeutic indications, reported data from its trial treating nonalcoholic steatohepatitis (NASH) open label with leronlimab.

[Stem Cell Research & Therapy] Scientists isolated human exfoliated deciduous teeth, namely biliary atresia-SHED, using a standard colony-forming unit fibroblast method and compared characteristics as MSCs to healthy donor-derived control SHED.