lung cancer

[Critical Reviews in Oncology/Hematology] As methods to culture lung cancer organoids increase in sophistication, this model will undoubtedly stand its ground in the coming years in every aspect of cancer researches, especially with major advantages in the field of personalized medicine and tumor microenvironment researches.

[Oncogene] Comparison of the 5mC and 5hmC sites revealed that the CD147 gene underwent active demethylation in NSCLC tissues compared with normal tissues, and this demethylation upregulated CD147 expression.

[Science Advances] Researchers found that TSC1/TSC2 loss defined a distinct subtype of NSCLC characterized as inflamed tumor microenvironment and superior sensitivity to immune checkpoint blockade.

[Cell Death & Disease] Investigators demonstrated the role of oncogenic Ras/syntenin-1 axis in the release of small extracellular vesicles (sEVs) and elucidated the function of syntenin-1-mediated miRNAs in sEVs in lung cancer progression.

[Cell Death & Disease] The authors investigated the biological functions and potential molecular mechanisms of miR-7-5p in NSCLC undergoing treatment with Everolimus.

[Journal of Cellular Physiology] The authors highlight exosomal micro- and long noncoding RNAs involved in lung cancer chemoresistance and address major molecular mechanisms, which connect corresponding RNA molecules to drug resistance.