MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.
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The authors update our understanding of B cell biology, review the results of clinical trials using B cell depletion therapies (BCDT) in autoimmune indications, discuss hypotheses for the mechanism of action of BCDT and speculate on evolving strategies for targeting B cells beyond depletion.
[Nature Reviews Drug Discovery]
The authors describe two aspects of the clinical therapeutic effects of human umbilical cord (hUCs)-MSCs. They explains the benefits and mechanisms of HUC-MSC treatment in various diseases.
[Stem Cell Research & Therapy]
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The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
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Psarras, A., Alase, A., Antanaviciute, A., Carr, I. M., Md Yusof, M. Y., Wittmann, M., Emery, P., Tsokos, G. C., & Vital, E. M. (2020). Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity. Nature Communications, 11(1), 6149. https://doi.org/10.1038/s41467-020-19918-z Cite
Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
[Cellular & Molecular Immunology]
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Researchers conducted a population-based case–control study investigating the association between chronic rhinosinusitis and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan.
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Shih, L.-C., Hsieh, H.-H., Tsay, G. J., Lee, I. T., Tsou, Y.-A., Lin, C.-L., Shen, T.-C., Bau, D.-T., Tai, C.-J., Lin, C.-D., & Tsai, M.-H. (2020). Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case–control study. Scientific Reports, 10(1), 18635. https://doi.org/10.1038/s41598-020-75815-x Cite
With murine and humanized MHC–/–HLA-A2+DR4+ murine models of chronic graft-versus-host disease (cGVHD), researchers showed that both murine and human PSGL1loCD4+ T cells from GVHD target tissues have features of B cell helpers with upregulated-expression of PD1 and ICOS and production of IL-21.
[Journal of Clinical Investigation]
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Using a humanized lupus mouse model, researchsrs showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total systemic lupus erythematosus PBMCs.
[Cellular & Molecular Immunology]
Functional analysis indicated that one subclass of antibodies bound strongly to decondensed DNA areas in neutrophil extracellular traps (NETs) and protected NETs from nuclease digestion, similar to the sera from active SLE patients.
[Cell Death & Disease]
Scientists determined the abundance and the nAg reactivity of IgA antibody produced in the intestine under lupus susceptibility. Intestinal lymphoid tissues from SNF1 mice, females particularly, showed significantly higher frequencies of nAg reactive IgA producing B cells compared to B6 females.
The authors compared four state-of-the-art methods and propose an approach to assign derived latent factors to pathway activities and specific cell subsets.