Tag Archives: lupus

Sorrento Enters Into Merger Agreement to Acquire Late-Stage Oncology Company ACEA Therapeutics

Sorrento Therapeutics, Inc. announced the signing of a merger agreement pursuant to which Sorrento will acquire ACEA Therapeutics, Inc. The acquisition will include late clinical stage drug Abivertinib, clinical stage candidate AC0058, preclinical stage candidate AC0939, and ACEA’s extensive proprietary library of small molecules, which potentially have applications for numerous human disease indications, including non-small cell lung cancer, B cell lymphomas, systemic lupus, rheumatoid arthritis, multiple sclerosis and viral infections.
[Sorrento Therapeutics, Inc. (Globe Newswire, Inc.)]
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Type I Interferons Affect the Metabolic Fitness of CD8+ T Cells from Patients with Systemic Lupus Erythematosus

Scientists showed downregulation of mitochondria-derived genes and mitochondria-associated metabolic pathways in IFN-High patients from transcriptomic analysis of CD4+ and CD8+ T cells.
[Nature Communications]
Buang, N., Tapeng, L., Gray, V., Sardini, A., Whilding, C., Lightstone, L., Cairns, T. D., Pickering, M. C., Behmoaras, J., Ling, G. S., & Botto, M. (2021). Type I interferons affect the metabolic fitness of CD8 + T cells from patients with systemic lupus erythematosus. Nature Communications, 12(1), 1980. https://doi.org/10.1038/s41467-021-22312-y Cite
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Suppressor of Cytokine Signaling-1 Mimetic Peptides Attenuate Lymphocyte Activation in the MRL/lpr Mouse Autoimmune Model

Using Fas deficient, MRL/MpJ-Faslpr/J mice, which develop lupus-like disease spontaneously, investigators tested the hypothesis that a peptide mimic of the suppressor of cytokine signaling-1 kinase inhibitory region would inhibit lymphocyte activation and modulate lupus-associated pathologies.
[Scientific Reports]
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B Cell-Specific XIST Complex Enforces X-inactivation and Restrains Atypical B Cells

Investigators showed XIST was continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7.
[Cell]
Yu, B., Qi, Y., Li, R., Shi, Q., Satpathy, A. T., & Chang, H. Y. (2021). B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.02.015 Cite
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Medical Progress: Stem Cells as a New Therapeutic Strategy for COVID-19

Researchers discuss the latest discoveries in molecular biology, a platform model of pluripotent stem cells in the SARS-CoV-2 study on 3D animal models and nanoconjugates based on stem cells.
[Stem Cell Research]
Musial, C., & Gorska-Ponikowska, M. (2021). Medical progress: Stem cells as a new therapeutic strategy for COVID-19. Stem Cell Research, 102239. https://doi.org/10.1016/j.scr.2021.102239 Cite
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Arachidonic Acid-Regulated Calcium Signaling in T Cells from Patients with Rheumatoid Arthritis Promotes Synovial Inflammation

Investigators showed that CD4+ T cells from patients with rheumatoid arthritis and psoriatic arthritis had increased expression of the pore-forming calcium channel component ORAI3.
[Nature Communications]
Ye, Z., Shen, Y., Jin, K., Qiu, J., Hu, B., Jadhav, R. R., Sheth, K., Weyand, C. M., & Goronzy, J. J. (2021). Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation. Nature Communications, 12(1), 907. https://doi.org/10.1038/s41467-021-21242-z Cite
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Modulation of αVβ6 Integrin in Osteoarthritis-Related Synovitis and the Interaction with VTN(381–397 A.A.) Competing for TGF-β1 Activation

Scientists observed that αVβ6 could mediate TGF-β1 bioavailability and that VTN(381–397 A.A.) could prevent TGF-β1 activation by interacting with αVβ6 in human fibroblast-like synoviocytes and increased α-SMA.
[Experimental and Molecular Medicine]
Ciregia, F., Deroyer, C., Cobraiville, G., Plener, Z., Malaise, O., Gillet, P., Fillet, M., Malaise, M. G., & de Seny, D. (2021). Modulation of α V β 6 integrin in osteoarthritis-related synovitis and the interaction with VTN (381–397 a.a.) competing for TGF-β1 activation. Experimental & Molecular Medicine, 1–13. https://doi.org/10.1038/s12276-021-00558-2 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Lupus through Increasing CD4+ T Cell Senescence via MiR-199a-5p/Sirt1/p53 Axis

MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.
[Theranostics]
Cheng, T., Ding, S., Liu, S., Li, Y., & Sun, L. (2021). Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics, 11(2), 893–905. https://doi.org/10.7150/thno.48080 Cite
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B Cell Depletion Therapies in Autoimmune Disease: Advances and Mechanistic Insights

The authors update our understanding of B cell biology, review the results of clinical trials using B cell depletion therapies (BCDT) in autoimmune indications, discuss hypotheses for the mechanism of action of BCDT and speculate on evolving strategies for targeting B cells beyond depletion.
[Nature Reviews Drug Discovery]
Lee, D. S. W., Rojas, O. L., & Gommerman, J. L. (2020). B cell depletion therapies in autoimmune disease: advances and mechanistic insights. Nature Reviews Drug Discovery, 1–21. https://doi.org/10.1038/s41573-020-00092-2 Cite
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What Is the Impact of Human Umbilical Cord Mesenchymal Stem Cell Transplantation on Clinical Treatment?

The authors describe two aspects of the clinical therapeutic effects of human umbilical cord (hUCs)-MSCs. They explains the benefits and mechanisms of HUC-MSC treatment in various diseases.
[Stem Cell Research & Therapy]
Xie, Q., Liu, R., Jiang, J., Peng, J., Yang, C., Zhang, W., Wang, S., & Song, J. (2020). What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment? Stem Cell Research & Therapy, 11(1), 519. https://doi.org/10.1186/s13287-020-02011-z Cite
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Functionally Impaired Plasmacytoid Dendritic Cells and Non-Haematopoietic Sources of Type I Interferon Characterize Human Autoimmunity

The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
[Nature Communications]
Psarras, A., Alase, A., Antanaviciute, A., Carr, I. M., Md Yusof, M. Y., Wittmann, M., Emery, P., Tsokos, G. C., & Vital, E. M. (2020). Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity. Nature Communications, 11(1), 6149. https://doi.org/10.1038/s41467-020-19918-z Cite
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