miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy

Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.
[Stem Cells International]
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Site-Specific PEGylation of Interleukin-2 Enhances Immunosuppression via the Sustained Activation of Regulatory T Cells

The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.
[Nature Biomedical Engineering]
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Norcantharidin Ameliorates the Development of Murine Lupus via Inhibiting the Generation of IL-17 Producing Cells

Researchers investigated whether norcantharidin (NCTD) exerted therapeutic effects in a mouse systemic lupus erythematosu model. Lupus prone female MRL/lpr mice were treated with NCTD for eight weeks.
[Acta Pharmacologica Sinica]
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Glutathione Peroxidase 4–Regulated Neutrophil Ferroptosis Induces Systemic Autoimmunity

The authors showed that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus undergo ferroptosis.
[Nature Immunology]
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SLC15A4 Mediates M1-Prone Metabolic Shifts in Macrophages and Guards Immune Cells from Metabolic Stress

Researchers investigated the mechanism of how SLC15A4 directed inflammatory responses. Proximity-dependent biotin identification revealed glycolysis as highly enriched gene ontology terms.
[Proceedings of the National Academy of Sciences of the United States of America]
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Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis through Upregulation TLR7 and IFN-α in Transgenic Mice

To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.
[Scientific Reports]
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FcγR Engagement Reprograms Neutrophils into Antigen Cross-Presenting Cells That Elicit Acquired Anti-tumor Immunity

Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.
[Nature Communications]
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Importance of Lymphocyte–Stromal Cell Interactions in Autoimmune and Inflammatory Rheumatic Diseases

The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases.
[Nature Reviews Rheumatology]
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Lupus Foundation of America Provides Six Grants to Young Scientists Supporting Important Lupus Research

The Lupus Foundation of America announced six recipients of the 2021 Gina M. Finzi Memorial Student Summer Fellowship Program. The fellowship program provides grant and mentorship support for young scientists and plays an important role in establishing the next generation of lupus researchers and the future of the lupus research field.
[The Lupus Foundation of America]
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Mesenchymal Stem Cells: Ideal Seeds for Treating Diseases

MSCs, a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, have become the “practical stem cells” for the treatment of diseases.
[Human Cell]
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New NIH Research Initiative Supported by LFA Focuses on the Causes of Inflammation and Clinical Disease

The Lupus Foundation of America has renewed its support for the National Institutes of Health (NIH) Accelerating Medicines Partnership (AMP) which recently announced a new initiative to discover the causes of inflammation and clinical disease. The new AMP Autoimmune and Immune-Mediated Diseases (AMP AIM) Program will use novel analytics to examine the interaction among innate and adaptive immune cells and tissue-resident cells.
[The Lupus Foundation of America]
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