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lymphocytes

Intravenous Calcitriol Administration Modulates Mesenteric Lymph Node CD4+ T-cell Polarization and Attenuates Intestinal Inflammation in Obese Mice Complicated with Polymicrobial Sepsis

[Journal of Parenteral and Enteral Nutrition] Researchers investigated treatment with calcitriol on mesenteric lymph node CD4+ T cell polarization and intestinal injury in obese mice with sepsis.

Spatial Determinates of Effector and Memory CD8+ T Cell Fates

[Immunological Reviews] The authors detail the inflammatory and chemokine regulators of spatially restricted T cell differentiation, with a focus on how to promote stem-like memory cell.

Clinical Characterization and Immunosuppressive Regulation of CD161 (KLRB1) in Glioma through 916 Samples

[Cancer Science] Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.

The Safety and Efficacy of CAR-T Cells in the Treatment of Prostate Cancer: Review

[Biomarkers] A new breakthrough development in cancer treatment is chimeric antigen receptor (CAR)-T cell therapy. The authors focus on its efficacy & safety in prostate cancer, obstacles impeding its clinical use, and some strategies trying to overcome them.

Homogeneous Antibody and CAR-T Cells with Improved Effector Functions Targeting SSEA-4 Glycan on Pancreatic Cancer

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.

Smart Immune Announces Research Collaboration with Memorial Sloan Kettering Cancer Center (MSK) to Expedite Development of a Next Generation CAR-T Through its Long Lasting,...

[Smart Immune SAS] Smart Immune SAS, a clinical stage T-cell medicine company utilizing its proprietary ex vivo biomimetic “thymus-in-a-dish” technology to develop T cell progenitors to reset a rapid, safe and full immune reconstitution, announced today a research collaboration with MSK.

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