lymphocytes

[Biomedicine & Pharmacotherapy] Investigators demonstrated that dominant negative TGF-β receptor type II specifically targeting T cells decreased tumor load in tumor-bearing mice.

[Cell Reports] Scientists reported that high-level mitochondrial respiration and constitutive low-level glycolysis supported liver sinusoidal endothelial cells scavenger and sentinel functions

[Cell Reports Medicine] By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis.

[Nature Metabolism] Scientists discuss recent studies and emerging research aimed to extend CAR-based therapies beyond oncology in areas such as cardiometabolic disorders, autoimmunity, fibrosis and senescence.

[Molecular Therapy-Oncolytics] Bi-specific T cell engager (BiTE-T) cells down-regulated CD3ε/TCRαβ on bystander T cells by releasing BiTEs.

[Molecular Therapy-Methods & Clinical Development] Scientists proposed adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, Tacrolimus, for optimized performance in the immunosuppressed patient.