lymphocytes

[Blood Cancer Journal] In CARTITUDE-1, 5% of patients with multiple myeloma reported movement and neurocognitive treatment-emergent adverse events with ciltacabtagene autoleucel (cilta-cel), a B cell maturation antigen-targeted CAR T cell therapy.

[European Respiratory Journal] The total number of cells and the differential cell counts in bronchoalveolar lavage were similar among the study groups.

[Haematologica] Researchers used sera from 61 immune thrombocytopenia patients and assessed the capacity of antiplatelet antibodies to induce neuraminidase 1 surface expression, RCA-1 lectin binding and loss of mitochondrial inner membrane potential on donors’ platelets.

[Clinical and Translational Medicine] Ten fresh human tissue samples from six patients, including primary tumor and adjacent non-tumoral samples and six metastases from different organs or tissues were evaluated using single-cell RNA sequencing.

[Molecular & Cellular Proteomics] Co-culturing primary CD8+ T cells with Tregs only modestly affected the CD8+ surfaceome but did partially reverse activation-induced surfaceomic changes.

[PLoS Pathogens] Researchers showed that natural killer (NK) cells directly killed extracellular P. aeruginosa using NK effector molecules.