lymphocytes

[Annals of Neurology] Scientists investigated prospectively humoral and cellular responses to SARS-CoV-2 mRNA vaccination in 82 patients with neuroimmunologic disorders on anti-CD20 therapy and 82 age- and sex-matched healthy controls.

[Journal of Experimental Medicine] Using single-cell transcriptomics and T cell receptor sequencing, scientists analyzed mononuclear cell populations in paired pleural fluid and peripheral blood of tuberculous pleural effusion patients.

[Cell] In subjects ∼6 months post-vaccination, 90% and 87% of memory T cell responses were preserved against variants on average by AIM assay, and 84% and 85% preserved against Omicron.

[Science Immunology] Investigators identified a critical signaling node that was engaged by effector memory T cells to mobilize a broad proinflammatory program in the innate immune system.

[Nature Communications] Researchers showed that administration of the A2A receptor agonist CGS-21680 depleted established CD11c+T-bet+ B cells in ehrlichial-infected mice, in a B cell-intrinsic manner.

[NPJ Vaccines] The authors demonstrated that intramuscular or intranasal vaccination of Syrian hamsters with COH04S1 induced robust Th1-biased antigen-specific humoral immunity and cross-neutralizing antibodies.