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lymphocytes
Dermal Cell News
SNF5, a Core Subunit of SWI/SNF Complex, Regulates Melanoma Cancer Cell Growth, Metastasis, and Immune Escape in Response to Matrix Stiffness
[Translational Oncology] Investigators suggested that stiffer substrate enhanced melanoma development by upregulating SNF5 expression, and SNF5 was a key mediator of stiffer matrix-induced immune evasion of melanoma cancer cells.
Pancreatic Cell News
Progranulin Mediates Immune Evasion of Pancreatic Ductal Adenocarcinoma through Regulation of MHCI Expression
[Nature Communications] Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.
Immune Regulation News
CAR T Cells Produced In Vivo to Treat Cardiac Injury
[Science] Scientists developed a therapeutic approach to generate transient antifibrotic CAR T cells in vivo by delivering modified mRNA in T cell–targeted lipid nanoparticles.
Human Immunology News
TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma
[Frontiers in Immunology] Scientists examined the effect of selectively blocking the function of sCTLA-4 on in vitro immune responses from volunteer healthy or melanoma patient PBMC samples.
Immune Regulation News
T Cell Receptor Beta Germline Variability Is Revealed by Inference from Repertoire Data
[Genome Medicine] Scientists adapted a B cell pipeline for undocumented alleles, genotype, and haplotype inference for full and partial adaptive immune receptor repertoire sequencing T cell receptor data sets.
Immune Regulation News
Modulatory Effects of R10 Fraction of Garlic (Allium sativum L.) on Hormonal Levels, T Cell Polarization, and Fertility-Related Genes in Mice Model of Polycystic...
[Journal of Ovarian Research] Treatment with R10 fraction, isolated from garlic, was performed and the alterations in hormonal levels, T cell polarization markers, and expression of fertility-related genes were evaluated.