lymphoid cells

[Blood Cancer Journal] To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of pediatric acute lymphoblastic leukemia, scientists analyzed tumor-normal whole genome sequencing and expression data from 361 newly diagnosed patients.

[Bone Marrow Transplantation] The authors evaluated long-term outcome in 40 patients with myelodysplastic syndrome or acute myeloid leukemia, transplanted from related or unrelated donors following conditioning with targeted busulfan, fludarabine, and thymoglobulin.

[Nature Communications] Scientists reported overexpression of human mature T cell proliferation 1 gene (MTCP1) restricted to the B cell compartment in mice produced a clonal CD5+/CD19+ leukemia recapitulating the major characteristics of human chronic lymphocytic leukemia.

[Cell Death Discovery] The abundance of myeloid-derived suppressor cells in the tumour microenvironment was associated with therapeutic efficacy and disease outcome. Scientists analyzed the changes in the immune contexture in response to the carbon ion treatment.

[Molecular Therapy-Methods & Clinical Development] Using a non-viral piggyBac transposon technology and human peripheral blood derived primary natural killer (NK) cells, scientists generated CAR-NK cells to target NKG2D ligands.

[Nature Communications] The authors developed third-generation anti-CD123 CAR T cells with a humanized CSL362-based ScFv and a CD28-OX40-CD3ζ intracellular signaling domain.