lymphoid cells

[Nature Communications] Investigators showed that the 4-1BB CSD-associated tonic signal yielded a more dramatic effect in CAR-Tregs than in CAR- conventional T cells with respect to activation and proliferation.

[Trends in Immunology] A spate of recent studies investigating tumor immune evasion through the application of CRISPR-based gene-editing screens have highlighted tumor necrosis factor (TNF)-mediated killing as an important component of the mammalian T cell antitumor repertoire.

[Current Opinion in Immunology] Data indicated that systemic and local chemo/radiotherapy regimens promoted intratumoral cytokine and chemokine upregulation, tumor antigen presentation and cross presentation, infiltration and in situ T cells reactivation.

[Cancer Cell] Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.

[American Journal of Human Genetics] Researchers systematically applied Mendelian randomization, genetic colocalization, immune-cell-type enrichment, and phenome-wide association methods to investigate the effects of genetically predicted gene expression on ten immune-associated diseases and four cancer outcomes.

[Heliyon] Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.