lymphoid cells

[Advanced Science] Transcriptomic analysis showed that IFN-γ and IFN-α signaling was downregulated in IRF8-deficient HSCs, while their response to proinflammatory cytokines was unchanged ex vivo.

[Scientific Reports] Scientists investigated the cellular response of different antigen presenting cells to the prototypical immunogenic heat shock protein, gp96, in the context of Th1 immunity.

[Nature Communications] Researchers showed that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converted neutrophils into neutrophil-derived cells with properties of dendritic cells (DCs) that activate T cells to levels observed with classical DCs.

[Blood] To target CD70 on acute myeloid leukemia cells, researchers generated a panel of CD70-CAR T cells that contained a common single-chain variable fragment for antigen detection, but differed in size and flexibility of the extracellular spacer and in the transmembrane and the costimulatory domains.

[PLOS Biology] Scientists demonstrated that natural killer cells were protected from perforin-mediated autolysis by densely packed and highly ordered presynaptic lipid membranes, which increased packing upon synapse formation.

[Cancer Discovery] The authors found that SHP2 inhibitor treatment depleted alveolar and M2-like macrophages, induced tumor-intrinsic CCL5/CXCL10 secretion and promoted B and T lymphocyte infiltration in Kras- and Egfr-mutant non-small cell lung cancer.