lymphoid cells

[Cell Reports Medicine] By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis.

[Nature Metabolism] Scientists discuss recent studies and emerging research aimed to extend CAR-based therapies beyond oncology in areas such as cardiometabolic disorders, autoimmunity, fibrosis and senescence.

[Molecular Therapy-Oncolytics] Bi-specific T cell engager (BiTE-T) cells down-regulated CD3ε/TCRαβ on bystander T cells by releasing BiTEs.

[Molecular Therapy-Methods & Clinical Development] Scientists proposed adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, Tacrolimus, for optimized performance in the immunosuppressed patient.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists utilized continuous live-cell imaging in vitro to track the division speed and genealogical connections of all descendants derived from a single naive CD8+ T cell throughout up to ten divisions of activation-induced proliferation.

[Nature Cancer] Investigators discuss recent studies of bystander T cells in tumors, including experimental and computational approaches that enable their identification and functional analysis.