malaria

[Science Advances] Hypothyroid mice displayed increased survival after infection with Plasmodium berghei ANKA, diminishing intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration.

[Cell Proliferation] Investigators generated ten O-negative hiPSC clones and evaluated their potential for mesoderm formation and erythroid differentiation, then used a perfusion bioreactor system to perform studies with high-density cultures of erythroblasts in vitro.

[Scientific Reports] By applying phage display technology, researchers mapped the protective epitope to be in the C-terminal region of Plasmodium falciparum rhoptry-associated membrane antigen.

[Trends in Parasitology] Understanding that antibodies play central roles in malaria immunity and systemic lupus erythematosus, the authors discuss how autoreactive B cells contribute to malaria immunity but promote SLE pathology in the absence of malaria.

[Cellular & Molecular Immunology] Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.

[Journal of Experimental Medicine] Scientists review recent efforts to gain a better molecular and cellular understanding of anti-Plasmodium falciparum circumsporozoite protein B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies.