mammary cells

[Journal of Antibiotics] Arthrifuranone A was isolation from an EtOAc-extract of Arthrinium pseudosinense culture medium and evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells.

[Journal of Bone and Mineral Research] In estrogen receptor positive (ER+) cells, oncostatin M (OSM) robustly stimulated phosphorylation of known gp130 signaling targets STAT3, ERK and AKT, while CNTF activated STAT3 signaling. In ER- breast cancer cells, OSM alone stimulated AKT and ERK signaling.

[Journal of Experimental & Clinical Cancer Research] TCGA analysis was performed to identify the clinical relevance of short stature homeobox 2 (SHOX2) in breast cancer. Molecular regulations and alterations were assessed by Western blotting, immunoprecipitation, immunohistochemistry, qRT-PCR, chromatin immunoprecipitation coupled with qPCR, and ChIP/re-ChIP.

[EMBO Journal] Scientists reported that the single nucleotide polymorphism (SNP) rs4971059, one of 65 new breast cancer risk loci identified in a recent genome-wide association study, functioned as an active enhancer of TRIM46 expression. TRIM46 promoted breast cancer cell proliferation and chemoresistance in vitro and accelerated tumor growth in vivo.

[Biochimie] To understand the role of the adipose-derived stem cell secretome in breast cancer cell proliferation, death, and phenotype alteration, adipose-derived stem cell-conditioned medium was used to cultivate MCF-7 and MDA-MB-231 cells.

[Toxicology and Applied Pharmacology] Investigators observed that proportion of CD133+Nanog+ subpopulation in MCF-7 cells was significantly increased after 3,3′-diindolylmethane administration with up-regulated AKT activity by using CyTOF assay.