mammary cells

[Breast Cancer Research] Researchers showed that sublethal doxorubicin treatment led to increased migration and invasion in otherwise non-invasive MCF7 breast cancer cells.

[Cancer Letters] MICAL1 gene disruption by CRISPR/Cas9 in MDA MB 231 human breast cancer cells knocked out protein expression, which affected F-actin organization, cell size and motility.

[Cell Death Discovery] The authors screened compounds inhibiting breast cancer cell proliferation with hematopoietic PBX-interacting protein (HPIP) fused with green fluorescent protein as a reporter. A novel agent named TXX-1-10 derived from rimonabant was discovered to reduce HPIP expression and had greater inhibitory effects on breast cancer cell growth and metastasis in vitro and in vivo than rimonabant.

[Cancer Chemotherapy and Pharmacology] The L-Arginine (Arg) auxotrophic cancerous cells like hepatocellular carcinoma, human colon cancer, leukemia, and breast cancer cells were sensitive to Arg depriving enzymes treatment due to low expression of crucial enzymes argininosuccinate synthetase, argininosuccinate lyase, and ornithine transcarbamylase.

[Journal of Cancer Research and Clinical Oncology] Musashi-1 was artificially downregulated in MCF-7 breast cancer cells and implications for cancer stem cell markers, cell apoptosis and apoptosis regulator p21, proliferation and radiation response were analyzed via flow cytometry and colony formation.

[Oncogene] Scientists found that DIF-1 induced phosphorylation of AMPK and Raptor and dephosphorylation of p70S6K in multiple TNBC cell lines.