A Novel Chemical Inhibitor Suppresses Breast Cancer Cell Growth and Metastasis through Inhibiting HPIP Oncoprotein

The authors screened compounds inhibiting breast cancer cell proliferation with hematopoietic PBX-interacting protein (HPIP) fused with green fluorescent protein as a reporter. A novel agent named TXX-1-10 derived from rimonabant was discovered to reduce HPIP expression and had greater inhibitory effects on breast cancer cell growth and metastasis in vitro and in vivo than rimonabant.