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Pulmonary Cell NewsThe L-Arginine (Arg) auxotrophic cancerous cells like hepatocellular carcinoma, human colon cancer, leukemia, and breast cancer cells were sensitive to Arg depriving enzymes treatment due to low expression of crucial enzymes argininosuccinate synthetase, argininosuccinate lyase, and ornithine transcarbamylase.
[Cancer Chemotherapy and Pharmacology]
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Kumari, N., & Bansal, S. (2021). Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment. Cancer Chemotherapy and Pharmacology. https://doi.org/10.1007/s00280-021-04335-w Cite
