mammary cells

[Science Translational Medicine] Investigators reported the discovery of a compound, called ErSO, that activated the anticipatory unfolded protein response and induced rapid and selective necrosis of estrogen receptor α-positive breast cancer cell lines in vitro.

[Cell Death & Differentiation] Investigators interrogated the role of YB-1 in newly arising human breast cancers as well as in established cell lines. Short-hairpin RNA-mediated knockdown of YB-1 in MDA-MB-231 cells blocked both their local tumour-forming and lung-colonising activity in immunodeficient mice.

[Cell Death Discovery] The authors provided novel findings on mitochondrial estrogen signaling in breast cancer cells and suggested the implementation of the dynamic BH3 technique as a tool to predict acquired endocrine therapy resistance.

[Scientific Reports] Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.

[Acta Pharmacologica Sinica] Researchers investigated whether and how inhibition of autophagy/mitophagy by cepharanthine affected the efficacy of chemotherapeutic agent epirubicin in TNBC cells in vitro and in vivo.

[Scientific Reports] Following conjugation to β-lactam-derivatized monomethyl auristatin F, tropomyosin receptor kinase B cell surface protein-targeting dual variable domain-antibody–drug conjugates showed potency against multiple breast cancer cell lines, including TNBC cell lines.