mammary cells

[npj Breast Cancer] Researchers utilized breast cancer patient-derived xenografts from the Mayo Breast Cancer Genome Guided Therapy Study to establish two immortalized, genomically unique breast cancer cell lines.

[Communications Biology] The authors investigated how the spatiotemporal receptor organization at the cell surface was modulated by biparatopic designed ankyrin repeat proteins (bipDARPins), which potently induced apoptosis in human epidermal growth factor receptor 2-addicted breast cancer cell lines.

[Cell Death & Disease] Researchers used Cell Counting Kit-8, colony formation, wound healing migration, Transwell invasion, and nude mouse xenograft assays to confirm the role of the lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) in the proliferation, migration of TNBC cells in vitro and in vivo.

[Cell Death & Disease] USP35 promoted the growth of ER+ breast cancer in vitro and in vivo, and reduced the sensitivity of ER+ breast cancer cells to endocrine therapies such as tamoxifen and fulvestrant.

[Cancer Cell International] Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.

[Laboratory Investigation] Using a previously established model of in vitro mineralization, the MDA-MB-231 human breast cancer cell line was induced using two osteogenic agents, inorganic phosphate and β-glycerophosphate, and direct monitoring of the mineralization process was conducted using Raman micro-spectroscopy.