mammary cells

[Cell Death & Disease] The authors identified OTU domain-containing 7B (OTUD7B) as a bona fide deubiquitylase of ERα in breast cancer, revealing a post-translational mechanism between ERα and OTUD7B in ERα-positive breast cancer.

[EMBO Journal] Researchers discovered selective upregulation of HSP70-family chaperone HSPA1 and its co-factors, HSPH1 and DNAJB1, in MCF7 breast cancer cells acquiring thermotolerance.

[Nature Communications] Scientists found that PIK3CA-mutant ER+ breast cancers exhibited increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling.

[Journal of Steroid Biochemistry and Molecular Biology] The authors investigated the potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in human breast and prostate cancer cells.

[Nature Communications] Scientists developed a strategy that enabled single-cell lipidomic analysis with high structural specificity and classified four subtypes of human breast cancer cells.

[Nature Communications] The authors suggested MutL loss as a predictive marker of sensitivity to combinatorial treatment with endocrine intervention and HER inhibitors in endocrine treatment-resistant ER+/HER2− breast cancer patients.