INPP4B Promotes PI3Kα-Dependent Late Endosome Formation and Wnt/β-Catenin Signaling in Breast Cancer

Scientists found that PIK3CA-mutant ER+ breast cancers exhibited increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling.