Wnt/β-catenin

[Cell Death Discovery] The authors demonstrated that HORMAD1 promotes the proliferation, migration and invasion of lung cancer cells both in vitro and in vivo by inducing epithelial–mesenchymal transition.

[Oncogene] Functional studies demonstrated that high GIPC2 expression due to CpG-island demethylation promoted increased metastatic capabilities of prostate cancer cells.

[Kaohsiung Journal of Medical Sciences] Researchers showed that the upregulation of thrombospondin 2 (THBS2) in colorectal cancer (CRC) tissues and CRC cell lines and high expression of THBS2 was correlated with poor overall survival.

[Cell Death & Differentiation] The authors showed that fatty acids activate Drp1 to promote metabolic plasticity in cancer cells. Uptake of fatty acids induced mitochondrial fragmentation by promoting ERK-dependent phosphorylation of Drp1 at the S616 site.

[Advanced Science] The assembly of self-organizing 3D kidney-like structures was observed. Kidney organoids contain podocytes, proximal tubules, and endothelial cells that form networks of capillary loop-like structures.

[Cell Death & Differentiation] Depletion of glycosyltransferase 8 domain containing 1 (GLT8D1) inhibited self-renewal of glioma stem cells in vitro and repressed tumor growth in glioma mouse models.