mass spectrometry

[Scientific Reports] Investigators examined if the pulmonary volatile organic compound spectrum related to primary graft dysfunction and postoperative outcomes.

[Cell Biochemistry and Biophysics] The authors investigated the effect of fatty acid binding protein 4 (FABP4) on lipogenesis in human skeletal muscle cells stimulated by Interleukin-4 and explored the mechanistic basis.

[Cell Communication and Signaling] The biological role of copine 1 (CPNE1) and receptor for activated C kinase 1 (RACK1) in NSCLC was investigated using gene expression knockdown and overexpression, cell proliferation assays, clonogenic assays, and Transwell assays.

[Communications Biology] By investigating the role of ARAF in NRAS-driven mouse melanoma through mass spectrometry experiments followed by a functional siRNA-based screen, scientists unexpectedly identified MITF as a direct ARAF partner.

[Molecular Cancer therapeutics] Scientists selected five NSCLC patient-derived xenografts (PDXs) with genetic alterations from established PDXs and the corresponding molecular targeted therapy was administered orally for 21 consecutive days.

[Science Advances] Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.