Macrophage-Derived Small Extracellular Vesicles Promote Biomimetic Mineralized Collagen-Mediated Endogenous Bone Regeneration

Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science]
Liu, A., Jin, S., Fu, C., Cui, S., Zhang, T., Zhu, L., Wang, Y., Shen, S. G. F., Jiang, N., & Liu, Y. (2020). Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-00100-6 Cite
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Borax Induces Osteogenesis by Stimulating NaBC1 Transporter via Activation of BMP Pathway

The intrinsic properties of MSCs make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ECMs and/or include soluble factors in the media. Scientists propose a simple approach based on ion transporter stimulation to determine stem cell fate that avoids the use of growth factors.
[Communications Biology]
Rico, P., Rodrigo-Navarro, A., Sánchez Pérez, L., & Salmeron-Sanchez, M. (2020). Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway. Communications Biology, 3(1), 1–15. https://doi.org/10.1038/s42003-020-01449-4 Cite
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Low-Intensity Vibration Restores Nuclear YAP Levels and Acute YAP Nuclear Shuttling in Mesenchymal Stem Cells Subjected to Simulated Microgravity

While both acute low-intensity vibrations and lysophosphohaditic acid treatments increased nuclear YAP entry by 50 and 87% over the basal levels in simulated microgravity(SMG)-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls.
[npj Microgravity]
Thompson, M., Woods, K., Newberg, J., Oxford, J. T., & Uzer, G. (2020). Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity. Npj Microgravity, 6(1), 1–11. https://doi.org/10.1038/s41526-020-00125-5 Cite
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GATA6 Regulates Aging of Human Mesenchymal Stem/Stromal Cells

Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
[Stem Cells]
Jiao, H., Walczak, B. E., Lee, M.-S., Lemieux, M. E., & Li, W.-J. (n.d.). GATA6 regulates aging of human mesenchymal stem/stromal cells. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3297 Cite
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Calidi Biotherapeutics Announces European Patent Granted by EPO: Combination Immunotherapy Approach for Treatment of Cancer

Calidi Biotherapeutics, Inc. announced that it has been granted a new patent from the European Patent Office (EPO). “Combination Immunotherapy Approach for Treatment of Cancer,” secures Calidi’s proprietary technology platform, Supernova 1, composed of the oncolytic agent, CAL1 vaccinia virus, loaded into allogeneic, adipose-derived MSCs.
[Calidi Biotherapeutics, Inc.]
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Logistics of an Advanced Therapy Medicinal Product during COVID-19 Pandemic in Italy: Successful Delivery of Mesenchymal Stromal Cells in Dry Ice

Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
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Mesenchymal Stem Cells Promote Pancreatic β-Cell Regeneration through Downregulation of FoxO1 Pathway

Researchers evaluated the regenerative potential of the murine pancreas post-human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC) administration through the intrapancreatic and intravenous route. Both routes of hTERT-MSC transplantation increased the incorporation of BrdU by pancreatic β-cells compared to control.
[Current Stem Cell Research & Therapy]
Khatri, R., Mazurek, S., Petry, S. F., & Linn, T. (2020). Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway. Stem Cell Research & Therapy, 11(1), 497. https://doi.org/10.1186/s13287-020-02007-9 Cite
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Fabrication of Hyaline-Like Cartilage Constructs using Mesenchymal Stem Cell Sheets

Researchers developed transplantable hyaline-like cartilage constructs by stimulating MSC chondrogenic differentiation as cell sheets.
[Scientific Reports]
Thorp, H., Kim, K., Kondo, M., Grainger, D. W., & Okano, T. (2020). Fabrication of hyaline-like cartilage constructs using mesenchymal stem cell sheets. Scientific Reports, 10(1), 20869. https://doi.org/10.1038/s41598-020-77842-0 Cite
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The Emerging Role of miR‐128 in Musculoskeletal Diseases

Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
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Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway

Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.
[Cellular and Molecular Neurobiology]
Sowmithra, S., Jain, N. K., Bhonde, R., & Datta, I. (2020). Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-020-01007-w Cite
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MiR-196b-5p Inhibits Proliferation of Wharton’s Jelly Umbilical Cord Stem Cells

Scientists report that overexpression of miR‐196b‐5p in Wharton’s jelly MSCs (WJCMSCs) suppressed proliferation and arrested the cell cycle in G0/G1 phase, whereas knock‐down of miR‐196b‐5p promotes WJCMSC proliferation and cell cycle progression.
[Febs Open Bio]
Han, X., Yang, H., Liu, H., Zhang, C., Cao, Y., Fan, Z., & Shi, R. (n.d.). MiR-196b-5p inhibits proliferation of Wharton’s jelly umbilical cord stem cells. FEBS Open Bio, n/a(n/a). https://doi.org/https://doi.org/10.1002/2211-5463.13043 Cite
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