Mesenchymal Stem Cell Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via miR-31-5p/ATF6 axis

Researchers investigated the role of MSC-exosomes on endplate chondrocytes with a tert-butyl hydroperoxide-induced oxidative stress cell model and an intervertebral disc degeneration rat model.
[Molecular Therapy-Nucleic Acids]
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A Study of Human Leukocyte Antigen‐Haploidentical Hematopoietic Stem Cells Transplantation Combined with Allogenic Mesenchymal Stem Cell Infusion for Treatment of Severe Aplastic Anemia in Pediatric and Adolescent Patients

The authors designed a combination of haplo‐hematopoietic stem cells transplantation with allogenic mesenchymal stem cells for treatment of severe aplastic anemia in pediatric and adolescent patients and evaluated its effects.
[Stem Cells Translational Medicine]
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Myh11+ Microvascular Mural Cells and Derived Mesenchymal Stem Cells Promote Retinal Fibrosis

Using lineage tracing technology, researchers demonstrated that after chemical ocular injury, Myh11+ mural cells detached from the retinal microvasculature and differentiated into myofibroblasts to form an epiretinal membrane.
[Scientific Reports]
Ray, H. C., Corliss, B. A., Bruce, A. C., Kesting, S., Dey, P., Mansour, J., Seaman, S. A., Smolko, C. M., Mathews, C., Dey, B. K., Owens, G. K., Peirce, S. M., & Yates, P. A. (2020). Myh11+ microvascular mural cells and derived mesenchymal stem cells promote retinal fibrosis. Scientific Reports, 10(1), 15808. https://doi.org/10.1038/s41598-020-72875-x Cite
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Osteogenic Differentiation Potential of Porcine Bone Marrow Mesenchymal Stem Cell Subpopulations Selected in Different Basal Media

Scientists evaluated the effects of αMEM, aDMEM, M199, αMEM/M199, aDMEM/M199 and αMEM/aDMEM mediaon porcine bone marrow MSC derivation, expression of number of osteogenic markers at fifth and tenth passage in multipotentporcine (p)MSCs before differentiation, and differentiation of pMSC to osteogenic lineage.
[Biology Open]
Kannan, S., Ghosh, J., & Dhara, S. K. (2020). Osteogenic differentiation potential of porcine bone marrow mesenchymal stem cell subpopulations selected in different basal media. Biology Open. https://doi.org/10.1242/bio.053280 Cite
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Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration

Scientists summarize the results of preclinical and clinical studies dealing with the introduction of epithelial and mesenchymal stem cells of the afterbirth origin to the liver failure therapy.
[Stem Cell Reviews and Reports]
Michalik, M., Gładyś, A., & Czekaj, P. (2020). Differentiation of Cells Isolated from Afterbirth Tissues into Hepatocyte-Like Cells and Their Potential Clinical Application in Liver Regeneration. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10045-2 Cite
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Clinical Effects of Intrathecal Administration of Expanded Wharton Jelly Mesenchymal Stromal Cells in Patients with Chronic Complete Spinal Cord Injury: A Randomized Controlled Study

Patients were randomly assigned to receive a single dose of intrathecal ex vivo-expanded Wharton’s jelly-MSCs from human umbilical cord or placebo and were then switched to the other arm at six months.
[Cytotherapy]
Albu, S., Kumru, H., Coll, R., Vives, J., Vallés, M., Benito-Penalva, J., Rodríguez, L., Codinach, M., Hernández, J., Navarro, X., & Vidal, J. (2020). Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2020.08.008 Cite
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Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MicroRNA-193a Reduces Cisplatin Resistance of Non-Small Cell Lung Cancer Cells via Targeting LRRC1

A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells-derived exosomes that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of non-small cell lung cancer cells.
[Cell Death & Disease]
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Peptidome Analysis of Umbilical Cord Mesenchymal Stem Cell (hUC-MSC) Conditioned Medium from Preterm and Term Infants

Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
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Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

Investigators studied the contribution of nestin+ bone marrow mesenchymal stem cells to MLL-AF9-driven acute myeloid leukemia development and chemoresistance in vivo.
[Cell Metabolism]
Forte, D., García-Fernández, M., Sánchez-Aguilera, A., Stavropoulou, V., Fielding, C., Martín-Pérez, D., López, J. A., Costa, A. S. H., Tronci, L., Nikitopoulou, E., Barber, M., Gallipoli, P., Marando, L., Castillejo, C. L. F. de, Tzankov, A., Dietmann, S., Cavo, M., Catani, L., Curti, A., … Méndez-Ferrer, S. (2020). Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.09.001 Cite
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A Novel lncRNA LNC_000052 Leads to the Dysfunction of Osteoporotic BMSCs via the miR-96-5p–PIK3R1 Axis

The authors found that both LNC_000052 and PIK3R1 shared a miRNA target, miR-96-5p, which was downregulated in osteoporotic bone-marrow derived MSCs.
[Cell Death & Disease]
Li, M., Cong, R., Yang, L., Yang, L., Zhang, Y., & Fu, Q. (2020). A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p–PIK3R1 axis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-03006-7 Cite
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Stem/Progenitor Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]
Wang, Y., Tang, Z., & Gu, P. (2020). Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials. Cell Death & Disease, 11(9), 1–14. https://doi.org/10.1038/s41419-020-02955-3 Cite
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