Human Endometrium-Derived Stem Cell Improves Cardiac Function after Myocardial Ischemic Injury by Enhancing Angiogenesis and Myocardial Metabolism

Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

Essent Biologics has announced the launch of its human MSCs for regenerative medicine, biopharmaceutical and cell therapy research. Essent Biologics will provide highly-characterized, low-passaged human MSCs.
[Essent Biologics]
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Mesenchymal Stromal Cell-Derived Exosomes in Cardiac Regeneration and Repair

Scientists summarize the potential mechanisms and therapeutic effects of MSC-derived exosomes in cardiac regeneration and repair and provide evidence to support their clinical application.
[Stem Cell Reports]
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Senolytics Improve Bone Forming Potential of Bone Marrow Mesenchymal Stem Cells from Aged Mice

By using a calvarial defect model, scientists showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged bone marrow MSC both in vitro and in vivo.
[npj Regenerative Medicine]
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Tailored Generation of Insulin Producing Cells from Canine Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissue

Researchers investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.
[Scientific Reports]
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Bio-Instructive Hydrogel Expands the Paracrine Potency of Mesenchymal Stem Cells

Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.
[Biofabrication]
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Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation In Vitro

Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.
[Scientific Reports]
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Differentiation of Human Adult-Derived Stem Cells towards a Neural Lineage Involves a Dedifferentiation Event Prior to Differentiation to Neural Phenotypes

Scientists demonstrated that hPDLSCs, hBMSCs and hDPSCs could directly differentiate into neuron-like cells without passing through a mitotic stage and that they shrunk dramatically and changed their morphology to that of neuron-like cells through active neurite extension.
[Scientific Reports]
Bueno, C., Martínez-Morga, M., García-Bernal, D., Moraleda, J. M., & Martínez, S. (2021). Differentiation of human adult-derived stem cells towards a neural lineage involves a dedifferentiation event prior to differentiation to neural phenotypes. Scientific Reports, 11(1), 12034. https://doi.org/10.1038/s41598-021-91566-9 Cite
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Emerging Understanding of Apoptosis in Mediating Mesenchymal Stem Cell Therapy

Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease]
Fu, Y., Sui, B., Xiang, L., Yan, X., Wu, D., Shi, S., & Hu, X. (2021). Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy. Cell Death & Disease, 12(6), 1–12. https://doi.org/10.1038/s41419-021-03883-6 Cite
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Human Umbilical Cord Mesenchymal Stem Cell Transfusion in Immune Non-Responders with AIDS: A Multicenter Randomized Controlled Trial

The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.
[Signal Transduction and Targeted Therapy]
Wang, L., Zhang, Z., Xu, R., Wang, X., Shu, Z., Chen, X., Wang, S., Liu, J., Li, Y., Wang, L., Zhang, M., Yang, W., Wang, Y., Huang, H., Tu, B., Liang, Z., Li, L., Li, J., Hou, Y., … Wang, F.-S. (2021). Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial. Signal Transduction and Targeted Therapy, 6(1), 1–8. https://doi.org/10.1038/s41392-021-00607-2 Cite
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