Scientists fabricated coaxial extruded core–shell tubular scaffolds and extrusion-based bioprinted cell-laden mesh scaffolds to mimic the functional niche in vitro.
[ACS Biomaterials Science & Engineering]
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Scientists elucidated whether thawed cryopreserved MSCs show comparable inhibitory effects on osteoarthritis progression in rats to those obtained with cultured MSCs.
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Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
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Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
The authors demonstrated that human marrow‐derived MSCs were antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either Mycobacterium avium and/or Mycobacterium intracellulare.
[Stem Cells Translational Medicine]
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Researchers evaluated the performance and quality of cancer treatment based on MSCs loaded by oncolytic reovirus in the cancerous C57BL/6 mouse model.
[Cancer Cell International]
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Seyed-Khorrami, S.-M., Soleimanjahi, H., Soudi, S., & Habibian, A. (2021). MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice. Cancer Cell International, 21(1), 244. https://doi.org/10.1186/s12935-021-01848-5 Cite
The authors compile and discuss study design data from ongoing clinical trials to address the key questions of ‘which’ tissue source, donor profile, isolation technique, culture conditions, long-term culture and cryopreservation for MSCs; the question of ‘when’ with regard to defining the transplantation window, by identifying and staging of patients based on their pro-inflammatory profile; and finally that of ‘how much’ with respect to the number of cells in a single administration, the number of doses and route of transplantation.
Investigators explore the several mechanisms through which MSCs impact on the supportive activity of the bone marrow niche and regulate hematopoietic stem and progenitor cell homeostasis.
[Frontiers in Cell and Developmental Biology]
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The authors evaluated the effects of two consecutive days of intratracheal administration of surfactant and human umbilical cord-mesenchymal stem cells on hyperoxia-induced lung injury.
[Stem Cell Research & Therapy]
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Chou, H.-C., Chang, C.-H., Chen, C.-H., Lin, W., & Chen, C.-M. (2021). Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats. Stem Cell Research & Therapy, 12(1), 258. https://doi.org/10.1186/s13287-021-02335-4 Cite
Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.
[Journal of Cellular and Molecular Medicine]
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Yip, H.-K., Lin, K.-C., Sung, P.-H., Chiang, J. Y., Yin, T.-C., Wu, R.-W., & Chen, K.-H. (n.d.). Umbilical cord-derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16577 Cite
Scientists uncovered a molecular fate switch, involving miR-206 and the transcription factor Runx1, that controls fibroadipogenic progenitor differentiation to adipocytes.
[Cell Stem Cell]
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Wosczyna, M. N., Carbajal, E. E. P., Wagner, M. W., Paredes, S., Konishi, C. T., Liu, L., Wang, T. T., Walsh, R. A., Gan, Q., Morrissey, C. S., & Rando, T. A. (2021). Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.04.008 Cite
Researchers evaluated the effect of allogenic mesenchymal stem cell transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy.
[International Journal of Molecular Sciences]
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Vištejnová, L., Liška, V., Kumar, A., Křečková, J., Vyčítal, O., Brůha, J., Beneš, J., Kolinko, Y., Blassová, T., Tonar, Z., Brychtová, M., Karlíková, M., Racek, J., Mírka, H., Hošek, P., Lysák, D., & Králíčková, M. (2021). Mesenchymal Stromal Cell Therapy in Novel Porcine Model of Diffuse Liver Damage Induced by Repeated Biliary Obstruction. International Journal of Molecular Sciences, 22(9), 4304. https://doi.org/10.3390/ijms22094304 Cite