Human BM-MSC Secretome Enhances Human Granulosa Cell Proliferation and Steroidogenesis and Restores Ovarian Function in Primary Ovarian Insufficiency Mouse Model

The authors report that the human mesenchymal stem cell (hMSC) secretome increased the proliferation of human granulosa cells (HGrC1). They showed by FACS analysis that treatment of HGrC1 cells with hMSC-conditioned media stimulated cellular proliferation.
[Scientific Reports]
Park, H., Chugh, R. M., El Andaloussi, A., Hobeika, E., Esfandyari, S., Elsharoud, A., Ulin, M., Garcia, N., Bilal, M., & Al-Hendy, A. (2021). Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Scientific Reports, 11(1), 4525. https://doi.org/10.1038/s41598-021-84216-7 Cite
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Adipose-Derived Mesenchymal Stem Cells Differentiate into Heterogeneous Cancer-Associated Fibroblasts in a Stroma-Rich Xenograft Model

By co-transplanting human adipose-derived mesenchymal stem cells and a human pancreatic ductal adenocarcinoma cell line into mice, a stroma-rich CDX model recapitulated the characteristics of clinical pancreatic cancer, such as accelerated tumor growth, abundant stromal proliferation, chemoresistance, and dense stroma formed from the heterogeneous cancer-associated fibroblasts.
[Scientific Reports]
Miyazaki, Y., Oda, T., Inagaki, Y., Kushige, H., Saito, Y., Mori, N., Takayama, Y., Kumagai, Y., Mitsuyama, T., & Kida, Y. S. (2021). Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model. Scientific Reports, 11(1), 4690. https://doi.org/10.1038/s41598-021-84058-3 Cite
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Repair of Segmental Bone Defect Using Tissue Engineered Heterogeneous Deproteinized Bone Doped with Lithium

Researchers demonstrated that lithium can induce the osteogenic differentiation inhibit of adipogenic differentiation of BMSCs by regulating the Wnt signaling pathway.
[Scientific Reports]
Li, J., Wang, W., Li, M., & Liu, L. (2021). Repair of segmental bone defect using tissue engineered heterogeneous deproteinized bone doped with lithium. Scientific Reports, 11(1), 4819. https://doi.org/10.1038/s41598-021-84526-w Cite
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Basement Membrane Proteins Modulate Cell Migration on Bovine Pericardium Extracellular Matrix Scaffold

By exploiting sideness (serous or fibrous surface) of antigen removed-bovine pericardium scaffolds, the authors aimed to determine the mechanism by which ECM niche influences human mesenchymal stem cell migration.
[Scientific Reports]
Xing, Q., Parvizi, M., Lopera Higuita, M., & Griffiths, L. G. (2021). Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. Scientific Reports, 11(1), 4607. https://doi.org/10.1038/s41598-021-84161-5 Cite
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MicroRNA-6785-5p-Loaded Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Suppress Angiogenesis and Metastasis in Gastric Cancer via INHBA

MiR-6785-5p and inhibin subunit beta A (INHBA) expression in gastric cancer (GC) tissues and cells were determined. GC cells were transfected with the vectors that altered miR-6785-5p or INHBA expression.
[Life Sciences]
Chen, Z., Xie, Y., Chen, W., Li, T., Chen, X., & Liu, B. (2021). microRNA-6785-5p-loaded human umbilical cord mesenchymal stem cells-derived exosomes suppress angiogenesis and metastasis in gastric cancer via INHBA. Life Sciences, 119222. https://doi.org/10.1016/j.lfs.2021.119222 Cite
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Challenges and Advances in Clinical Applications of Mesenchymal Stromal Cells

Scientists discuss the major challenges of MSC therapies in clinical application, the factors impacting the diversity of MSCs, the potential approaches that modify MSC products with the highest therapeutic potential, and finally the usage of MSCs for COVID-19 pandemic disease.
[Journal of Hematology & Oncology]
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P. (2021). Challenges and advances in clinical applications of mesenchymal stromal cells. Journal of Hematology & Oncology, 14(1), 24. https://doi.org/10.1186/s13045-021-01037-x Cite
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Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging

Researchers isolated exosomes derived from umbilical cord MSCs grown in a 3D culture system and explored their ability to modulate the photo-aging of HaCaT keratinocytes.
[Rejuvenation Research]
Liu, S.-J., Meng, M.-Y., Han, S., Gao, H., Zhao, Y.-Y., Yang, Y., Lin, Z.-Y., Yang, L.-R., Zhu, K., Han, R., Huang, W.-W., Wang, R.-Q., Yang, L.-L., Wang, W.-J., Li, L., Wang, X.-D., Hou, Z.-L., Liao, L. W., & Yang, L. (2021). Umbilical cord mesenchymal stem cell-derived exosomes ameliorate HaCaT cell photo-aging. Rejuvenation Research. https://doi.org/10.1089/rej.2020.2313 Cite
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Vitamin E Pretreated Wharton’s Jelly-Derived Mesenchymal Stem Cells Attenuate CCl4-Induced Hepatocyte Injury In Vitro and Liver Fibrosis In Vivo

The authors used rat liver-derived hepatocytes injured by CCl4 treatment in co-culture system with Vitamin E pretreated-Wharton’s jelly-derived MSCs (WJMSCs) to evaluate the hepatoprotective effect of vitamin E-WJMSCs.
[Biochemical Pharmacology]
Tayyab Baig, M., Ghufran, H., Mehmood, A., Azam, M., Humayun, S., & Riazuddin, S. (2021). Vitamin E pretreated Wharton’s jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo. Biochemical Pharmacology, 114480. https://doi.org/10.1016/j.bcp.2021.114480 Cite
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Human Mesenchymal Stem Cells Promote Ischemic Repairment and Angiogenesis of Diabetic Foot through Exosome miRNA-21-5p

Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research]
Huang, C., Luo, W., Wang, Q., Ye, Y., Fan, J., Lin, L., Shi, C., Wei, W., Chen, H., Wu, Y., & Tang, Y. (2021). Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p. Stem Cell Research, 52, 102235. https://doi.org/10.1016/j.scr.2021.102235 Cite
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Therapeutic Effects of Wharton’s Jelly-Derived Mesenchymal Stromal Cells on Behaviors, EEG Changes and NGF-1 in Rat Model of the Parkinson’s Disease

The effects of human Wharton’s jelly-derived MSCs on hyperalgesia, anxiety deficiency and Pallidal local electroencephalogram impairment, alone and combined with L-dopa, were examined in a rat model of Parkinson’s disease.
[Journal of Chemical Neuroanatomy]
Jalali, M. S., Saki, G., Farbood, Y., Azandeh, S. saeed, Mansouri, E., Ghasemi Dehcheshmeh, M., & Sarkaki, A. (2021). Therapeutic effects of Wharton’s jelly-derived Mesenchymal Stromal Cells on behaviors, EEG changes and NGF-1 in rat model of the Parkinson’s disease. Journal of Chemical Neuroanatomy, 113, 101921. https://doi.org/10.1016/j.jchemneu.2021.101921 Cite
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling

Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice]
Wang, Y., Liu, J., Zhang, Q., Wang, W., Liu, Q., Liu, S., Song, Y., Wang, X., Zhang, Y., Li, S., Yang, X., Lv, S., & Liu, G. (2021). Human Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury under High Glucose via TLR2 and TLR4 Signaling. Diabetes Research and Clinical Practice, 0(0). https://doi.org/10.1016/j.diabres.2021.108702 Cite
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