Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science]
6630899 ADXLNF7A items 1 apa default asc 1
Liu, A., Jin, S., Fu, C., Cui, S., Zhang, T., Zhu, L., Wang, Y., Shen, S. G. F., Jiang, N., & Liu, Y. (2020). Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-00100-6 Cite
The intrinsic properties of MSCs make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ECMs and/or include soluble factors in the media. Scientists propose a simple approach based on ion transporter stimulation to determine stem cell fate that avoids the use of growth factors.
While both acute low-intensity vibrations and lysophosphohaditic acid treatments increased nuclear YAP entry by 50 and 87% over the basal levels in simulated microgravity(SMG)-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls.
6630899 8U95Y3P2 items 1 apa default asc 1
Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
Calidi Biotherapeutics, Inc. announced that it has been granted a new patent from the European Patent Office (EPO). “Combination Immunotherapy Approach for Treatment of Cancer,” secures Calidi’s proprietary technology platform, Supernova 1, composed of the oncolytic agent, CAL1 vaccinia virus, loaded into allogeneic, adipose-derived MSCs.
[Calidi Biotherapeutics, Inc.]
6630899 nan items 1 apa default asc 1
Researchers assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of umbilical cord-MSCs to clinics.
[Journal of Translational Medicine]
6445212 JFZS4BL4 items 1 apa default asc 1
Astori, G., Bernardi, M., Bozza, A., Catanzaro, D., Chieregato, K., Merlo, A., Santimaria, M., Barbazza, R., Amodeo, G., Ciccocioppo, R., Elice, F., & Ruggeri, M. (2020). Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice. Journal of Translational Medicine, 18(1), 451. https://doi.org/10.1186/s12967-020-02625-0 Cite
Researchers evaluated the regenerative potential of the murine pancreas post-human telomerase reverse transcriptase mesenchymal stem cells (hTERT-MSC) administration through the intrapancreatic and intravenous route. Both routes of hTERT-MSC transplantation increased the incorporation of BrdU by pancreatic β-cells compared to control.
[Current Stem Cell Research & Therapy]
Researchers developed transplantable hyaline-like cartilage constructs by stimulating MSC chondrogenic differentiation as cell sheets.
Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
1254621 NY53KRHD items 1 apa default asc 1
Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
Cellular deregulation was assessed by measuring glutathione levels, basal calcium and intracellular calcium response under KCl stimulation, as well as the key parameters of proliferation, glial progenitor marker expression and migration.
[Cellular and Molecular Neurobiology]
6445212 C8MYKXJK items 1 apa default asc 1
Sowmithra, S., Jain, N. K., Bhonde, R., & Datta, I. (2020). Recovery of Human Embryonic Stem Cells-Derived Neural Progenitors Exposed to Hypoxic-Ischemic-Reperfusion Injury by Indirect Exposure to Wharton’s Jelly Mesenchymal Stem Cells Through Phosphatidyl-inositol-3-Kinase Pathway. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-020-01007-w Cite
Scientists report that overexpression of miR‐196b‐5p in Wharton’s jelly MSCs (WJCMSCs) suppressed proliferation and arrested the cell cycle in G0/G1 phase, whereas knock‐down of miR‐196b‐5p promotes WJCMSC proliferation and cell cycle progression.
[Febs Open Bio]
6445212 NYITQBIE items 1 apa default asc 1
Han, X., Yang, H., Liu, H., Zhang, C., Cao, Y., Fan, Z., & Shi, R. (n.d.). MiR-196b-5p inhibits proliferation of Wharton’s jelly umbilical cord stem cells. FEBS Open Bio, n/a(n/a). https://doi.org/https://doi.org/10.1002/2211-5463.13043 Cite