Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
Abstract

Continue reading “Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes”

Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential

Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2020). Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. Journal of Neurology. https://doi.org/10.1007/s00415-020-10138-5 Cite
Abstract

Continue reading “Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential”

Bookmark

No account yet? Register

0
Share

Exosomes — Beyond Stem Cells for Cardiac Protection and Repair

Scientists discuss the therapeutic benefit of exosomes secreted by stem and progenitor cells in preclinical models of ischemic heart disease.
[Stem Cells]
Balbi, C., & Vassalli, G. (n.d.). Exosomes — Beyond Stem Cells for Cardiac Protection and Repair. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3261 Cite
Abstract

Continue reading “Exosomes — Beyond Stem Cells for Cardiac Protection and Repair”

Bookmark

No account yet? Register

0
Share

Promotion of the Immunomodulatory Properties and Osteogenic Differentiation of Adipose‐Derived Mesenchymal Stem Cells In Vitro by Lentivirus‐Mediated miR‐146a Sponge Expression

Investigators employed miRNA sponges that were forcibly expressed using a lentiviral vector to knock‐down the expression of miR‐146a in human adipose‐derived stem cells.
[Journal of Tissue Engineering and Regenerative Medicine]
Wan, S., Wu, Q., Ji, Y., Fu, X., & Wang, Y. (n.d.). Promotion of the immunomodulatory properties and osteogenic differentiation of adipose-derived mesenchymal stem cells in vitro by lentivirus-mediated miR-146a sponge expression. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3113 Cite
Abstract

Continue reading “Promotion of the Immunomodulatory Properties and Osteogenic Differentiation of Adipose‐Derived Mesenchymal Stem Cells In Vitro by Lentivirus‐Mediated miR‐146a Sponge Expression”

Bookmark

No account yet? Register

0
Share

Doxycycline Restores the Impaired Osteogenic Commitment of Diabetic-Derived Bone Marrow Mesenchymal Stromal Cells by Increasing the Canonical WNT Signaling

Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
Gomes, P. S., Resende, M., & Fernandes, M. H. (2020). Doxycycline restores the impaired osteogenic commitment of diabetic-derived bone marrow mesenchymal stromal cells by increasing the canonical WNT signaling. Molecular and Cellular Endocrinology, 110975. https://doi.org/10.1016/j.mce.2020.110975 Cite
Abstract

Continue reading “Doxycycline Restores the Impaired Osteogenic Commitment of Diabetic-Derived Bone Marrow Mesenchymal Stromal Cells by Increasing the Canonical WNT Signaling”

Bookmark

No account yet? Register

0
Share

Enhancing Myocardial Repair with CardioClusters

Mesenchymal stem cells, endothelial progenitor cells and c-Kit+ cardiac interstitial cells when cultured together spontaneously formed scaffold-free 3D microenvironments termed CardioClusters.
[Nature Communications]
Monsanto, M. M., Wang, B. J., Ehrenberg, Z. R., Echeagaray, O., White, K. S., Alvarez, R., Fisher, K., Sengphanith, S., Muliono, A., Gude, N. A., & Sussman, M. A. (2020). Enhancing myocardial repair with CardioClusters. Nature Communications, 11(1), 3955. https://doi.org/10.1038/s41467-020-17742-z Cite
Full Article

Continue reading “Enhancing Myocardial Repair with CardioClusters”

Bookmark

No account yet? Register

0
Share

Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
Full Article

Continue reading “Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis”

Bookmark

No account yet? Register

0
Share

A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease

A two-dose cohort trial allogeneic Wharton’s Jelly-derived mesenchymal stromal cells were tested in ten patients with de novo high risk or steroid refractory acute graft versus host disease post allogeneic hematopoietic stem cell transplantation.
[Stem Cell Reviews and Reports]
Soder, R. P., Dawn, B., Weiss, M. L., Dunavin, N., Weir, S., Mitchell, J., Li, M., Shune, L., Singh, A. K., Ganguly, S., Morrison, M., Abdelhakim, H., Godwin, A. K., Abhyankar, S., & McGuirk, J. (2020). A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10015-8 Cite
AbstractGraphical Abstract

Continue reading “A Phase I Study to Evaluate Two Doses of Wharton’s Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease”

Bookmark

No account yet? Register

0
Share

Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review

The authors systematically review literature pertaining to hematopoietic stem cell (HSC) based tissue engineering strategies in animal models of chondral repair such that trends may be identified and the utility of HSCs in chondral repair can be elucidated
[Tissue Engineering]
Kabir, W., Di Bella, C., Gould, D., Jo, I., & Choong, P. (2020). Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.TEB.2020.0155 Cite
Abstract

Continue reading “Human Stem Cell Based Tissue Engineering for In Vivo Cartilage Repair: A Systematic Review”

Bookmark

No account yet? Register

0
Share

Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study

67 patients were treated with Wharton’s jelly mesenchymal stem cells. The treated patients were paired with 67 reference patients from the PRO-ACT database which contains patient records from 23 amyotrophic lateral sclerosis clinical studies
[Stem Cell Reviews and Reports]
Barczewska, M., Maksymowicz, S., Zdolińska-Malinowska, I., Siwek, T., & Grudniak, M. (2020). Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10016-7 Cite
Full ArticleGraphical Abstract

Continue reading “Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis: an Original Study”

Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cells‐Derived and siRNAs‐Encapsulated Exosomes Inhibit Osteonecrosis of the Femoral Head

The authors explored the role of bone mesenchymal stem cells‐derived and siRNAs‐encapsulated exosomes in osteonecrosis of the femoral head.
[Journal of Cellular and Molecular Medicine]
Zhang, C., Su, Y., Ding, H., Yin, J., Zhu, Z., & Song, W. (n.d.). Mesenchymal stem cells-derived and siRNAs-encapsulated exosomes inhibit osteonecrosis of the femoral head. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15395 Cite
Full Article

Continue reading “Mesenchymal Stem Cells‐Derived and siRNAs‐Encapsulated Exosomes Inhibit Osteonecrosis of the Femoral Head”

Bookmark

No account yet? Register

0
Share

Dental Follicle Stem Cells Rescue the Regenerative Capacity of Inflamed Rat Dental Pulp through a Paracrine Pathway

Researchers focused on the paracrine effects of rat dental follicle stem cells (DFSCs) on the inflammation and regeneration of rat injured dental pulp to detect whether DFSCs are a potential candidate for mesenchymal stem cell-based minimally invasive vital pulp therapy.
[Stem Cell Research & Therapy]
Hong, H., Chen, X., Li, K., Wang, N., Li, M., Yang, B., Yu, X., & Wei, X. (2020). Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway. Stem Cell Research & Therapy, 11(1), 333. https://doi.org/10.1186/s13287-020-01841-1 Cite
Full Article

Continue reading “Dental Follicle Stem Cells Rescue the Regenerative Capacity of Inflamed Rat Dental Pulp through a Paracrine Pathway”

Bookmark

No account yet? Register

0
Share
Share