mesenchymal stem cells

[Ebiomedicine] Scientists summarize the major pathological characteristics of COVID-19 and provide scientific and rational evidence for the safety and possible effectiveness of MSCs in COVID-19 treatment.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Environmental Science and Pollution Research] Stem cells from rat kidney were separated, and the surface stem cell markers were determined by flow cytometry analysis.

[Acta Biomaterialia] Researchers used in vitro and in vivo assays to demonstrate that articular cartilage and bone ECM derived scaffolds could preferentially direct the differentiation of mesenchymal stromal cells (MSCs) towards either a chondrogenic or osteogenic lineage, respectively.

[Molecular Therapy-Methods & Clinical Development] As efficient adenovirus type 5-mediated gene transfer would greatly increase the therapeutic potential of human MSCs (hMScs), researchers tested the hypothesis that introducing positively charged amino acids into Hexon might have enhanced the transduction of hMSCs, enabling efficient expression of selected transgenes.

[Stem Cell Research & Therapy] Investigators examined whether by phosphatase regenerating liver-1, overexpressed placental-derived-MSCs, could maximize the angiogenic effects in ovarian tissues injured of a rat model with partial ovariectomy.