Continue reading “Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats”
Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
1254621 CH8SZ5IJ items 1 apa default asc 1
Noori, L., Arabzadeh, S., Mohamadi, Y., Mojaverrostami, S., Mokhtari, T., Akbari, M., & Hassanzadeh, G. (2020). Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats. Neuroscience Research. https://doi.org/10.1016/j.neures.2020.07.011 Cite
Researchers showed MIR22HG, which has been demonstrated to be involved in the progression of several cancer types, played an important role in regulating bone marrow mesenchymal stem cell osteogenesis.
[Cell Death & Disease]
Exosomes were isolated from control and IFN-γ-primed mesenchymal stem cells and were verified by transmission electron microscope and immunofluorescence staining.
[Cell Death & Disease]
Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
1254621 AC4QMCU8 items 1 apa default asc 1
Yang, H., Fierro, F., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo‐Castro, T., Alex, A., Stewart, H., Chigbrow, M., Dasu, M. R., Peavy, T. R., Soulika, A. M., Nolta, J. A., & Isseroff, R. R. (n.d.). Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.19-0380 Cite
Scientists analyzed the fusion process in connection with structure and mechanical properties of the spheroids from human somatic cells of different phenotypes: mesenchymal stem cells from the limbal eye stroma and epithelial cells from retinal pigment epithelium.
6630899 E4CTX7SY items 1 apa default asc 1
Kosheleva, N. V., Efremov, Y. M., Shavkuta, B. S., Zurina, I. M., Zhang, D., Zhang, Y., Minaev, N. V., Gorkun, A. A., Wei, S., Shpichka, A. A., Saburina, I. N., & Timashev, P. S. (2020). Cell spheroid fusion: beyond liquid drops model. Scientific Reports, 10(1), 12614. https://doi.org/10.1038/s41598-020-69540-8 Cite
Mesoblast Limited announced that the Oncologic Drugs Advisory Committee of the United States Food and Drug Administration has scheduled a meeting on August 13, 2020 to review data supporting the Company’s Biologics License Application for approval of RYONCIL™ for the treatment of steroid-refractory acute graft versus host disease in children.
Researchers overexpressed pigment epithelium-derived factor (PEDF) in placenta-derived mesenchymal stem cells (PD-MSCsPEDF) using a nonviral gene delivery system and evaluated the characteristics of PD-MSCsPEDF and their potential regenerative effects on retinal pigment epithelial cells damaged by H2O2-induced oxidative stress.
1254621 B3KENBC5 items 1 apa default asc 1
Kim, J. Y., Park, S., Park, S. H., Lee, D., Kim, G. H., Noh, J. E., Lee, K. J., & Kim, G. J. (2020). Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. Laboratory Investigation, 1–19. https://doi.org/10.1038/s41374-020-0470-z Cite
Scientists found that Ryk—an atypical Wnt receptor with a pseudokinase domain—had a Wnt-modulating effect in bone marrow stromal cells to control hematopoiesis-supporting activities.
[Experimental and Molecular Medicine]
The authors investigated therapeutic efficiency and potential mechanism of probucol combined with mesenchymal stem cells.
[Stem Cell Research & Therapy]
1254621 XD44S3F5 items 1 apa default asc 1
Wang, H., Zhang, K., Ruan, Z., Sun, D., Zhang, H., Lin, G., Hu, L., Zhao, S., & Fu, Q. (2020). Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Research & Therapy, 11(1), 302. https://doi.org/10.1186/s13287-020-01788-3 Cite
The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
1254621 K57MAXHB items 1 apa default asc 1
Yang, Y., Cao, T.-T., Tian, Z.-M., Gao, H., Wen, H.-Q., Pang, M., He, W.-J., Wang, N.-X., Chen, Y.-Y., Wang, Y., Li, H., Lin, J.-W., Kang, Z., Li, M.-M., Liu, B., & Rong, L.-M. (2020). Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Experimental Cell Research, 112184. https://doi.org/10.1016/j.yexcr.2020.112184 Cite
Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
1254621 MP4EFWGH items 1 apa default asc 1
Sahab Negah, S., Shirzad, M. M., Biglari, G., Naseri, F., Hosseini Ravandi, H., Hassani Dooghabadi, A., & Gorji, A. (2020). Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03247-0 Cite
C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
1254621 JQMMSZ86 items 1 apa default asc 1