Platelet lysate (PL) had been shown to induce chondrogenic differentiation of human umbilical cord‐derived MSCs Scientists investigated whether long non‐coding RNA H19 was involved in this process. Human umbilical cord MSCs were isolated, identified, and cultured in 5% PL‐supplemented chondrogenic differentiation medium
[Febs Open Bio]
Global Stem Cells Group (GSCG) has signed a historic agreement with a company known as Bioscience Cell Factor- this Dubai-based healthcare company will allow GSCG to act as their representatives operating in both the Middle East and Latin America.
[Global Stem Cells Group]
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Investigators demonstrated that Msh homeobox 1 (Msx1) promotes the proliferation of myoblasts and mesenchymal stem cells by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research]
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Umbilical cord-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established bronchopulmonary dysplasia were enrolled in this study between May 25, 2018, and December 31, 2018.
[Journal of Translational Medicine]
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Nguyen, L. T., Trieu, T. T. H., Bui, H. T. H., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. (2020). Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. Journal of Translational Medicine, 18(1), 398. https://doi.org/10.1186/s12967-020-02568-6 Cite
Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133−/CD44−, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
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Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
The authors present the role of exosomes in the tumor microenvironment and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.
[Signal Transduction and Targeted Therapy]
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Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020). Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00359-5 Cite
The aryl hydrocarbon receptor has potential to be an attractive target in both endogenous and culture‐adapted MSCs for novel therapeutics to treat inflammation and other age‐related disorders.
The authors shed light on the mechanistic view of MSC therapeutic role based on preclinical and clinical studies on acute lung injury and ARDS; therefore, offering a unique correlation and applicability in COVID-19 patients. They further highlight the challenges and opportunities in the use of MSC-based therapy.
[Stem Cell Research & Therapy]
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The authors investigated the effect of a standard of care chemotherapeutic agent Doxorubicin (Dox) on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). They found that the exosome secreted by Dox-treated MSC induced a higher degree of Dox resistance in BCs when compared with non-treated MSC-exo.
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Luo, T., Liu, Q., Tan, A., Duan, L., Jia, Y., Nong, L., Tang, J., Zhou, W., Xie, W., Lu, Y., Yu, Q., & Liu, Y. (2020). Mesenchymal stem cells-secreted exosome promotes chemoresistance in breast cancer via enhancing miR-21-5p-mediated S100A6 expression. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.10.008 Cite
Scientists identified appropriate reference genes for normalization of miRNA expression in bone marrow-MSCs and HS27a and HS5 cell lines in various conditions including normoxia, hypoxia, co-culture, as model for the hematopoietic niche and after induced differentiation as model for regenerative medicine.
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Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived mesenchymal stem cells with knocked down Numb gene were treated with Huang Qi Decoction.
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Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis | Scientific Reports. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41598-020-74324-1 Cite