Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
[Neuroscience Research]
Noori, L., Arabzadeh, S., Mohamadi, Y., Mojaverrostami, S., Mokhtari, T., Akbari, M., & Hassanzadeh, G. (2020). Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats. Neuroscience Research. https://doi.org/10.1016/j.neures.2020.07.011 Cite
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Long Non-Coding RNA MIR22HG Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via PTEN/AKT Pathway

Researchers showed MIR22HG, which has been demonstrated to be involved in the progression of several cancer types, played an important role in regulating bone marrow mesenchymal stem cell osteogenesis.
[Cell Death & Disease]
Jin, C., Jia, L., Tang, Z., & Zheng, Y. (2020). Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway. Cell Death & Disease, 11(7), 1–13. https://doi.org/10.1038/s41419-020-02813-2 Cite
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IFN-γ Promoted Exosomes from Mesenchymal Stem Cells to Attenuate Colitis via miR-125a and miR-125b

Exosomes were isolated from control and IFN-γ-primed mesenchymal stem cells and were verified by transmission electron microscope and immunofluorescence staining.
[Cell Death & Disease]
Yang, R., Huang, H., Cui, S., Zhou, Y., Zhang, T., & Zhou, Y. (2020). IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b. Cell Death & Disease, 11(7), 1–12. https://doi.org/10.1038/s41419-020-02788-0 Cite
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Combination Product of Dermal Matrix, Human Mesenchymal Stem Cells, and Timolol Promotes Diabetic Wound Healing in Mice

Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
Yang, H., Fierro, F., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo‐Castro, T., Alex, A., Stewart, H., Chigbrow, M., Dasu, M. R., Peavy, T. R., Soulika, A. M., Nolta, J. A., & Isseroff, R. R. (n.d.). Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.19-0380 Cite
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Cell Spheroid Fusion: Beyond Liquid Drops Model

Scientists analyzed the fusion process in connection with structure and mechanical properties of the spheroids from human somatic cells of different phenotypes: mesenchymal stem cells from the limbal eye stroma and epithelial cells from retinal pigment epithelium.
[Scientific Reports]
Kosheleva, N. V., Efremov, Y. M., Shavkuta, B. S., Zurina, I. M., Zhang, D., Zhang, Y., Minaev, N. V., Gorkun, A. A., Wei, S., Shpichka, A. A., Saburina, I. N., & Timashev, P. S. (2020). Cell spheroid fusion: beyond liquid drops model. Scientific Reports, 10(1), 12614. https://doi.org/10.1038/s41598-020-69540-8 Cite
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FDA Advisory Committee Sets Review Date for Mesoblast’s Remestemcel-L in Pediatric Steroid-Refractory Acute Graft versus Host Disease

Mesoblast Limited announced that the Oncologic Drugs Advisory Committee of the United States Food and Drug Administration has scheduled a meeting on August 13, 2020 to review data supporting the Company’s Biologics License Application for approval of RYONCIL™ for the treatment of steroid-refractory acute graft versus host disease in children.
[Mesoblast Ltd]
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Overexpression of Pigment Epithelium-Derived Factor in Placenta-Derived Mesenchymal Stem Cells Promotes Mitochondrial Biogenesis in Retinal Cells

Researchers overexpressed pigment epithelium-derived factor (PEDF) in placenta-derived mesenchymal stem cells (PD-MSCsPEDF) using a nonviral gene delivery system and evaluated the characteristics of PD-MSCsPEDF and their potential regenerative effects on retinal pigment epithelial cells damaged by H2O2-induced oxidative stress.
[Laboratory Investigation]
Kim, J. Y., Park, S., Park, S. H., Lee, D., Kim, G. H., Noh, J. E., Lee, K. J., & Kim, G. J. (2020). Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. Laboratory Investigation, 1–19. https://doi.org/10.1038/s41374-020-0470-z Cite
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Ryk Modulates the Niche Activity of Mesenchymal Stromal Cells by Fine-Tuning Canonical Wnt Signaling

Scientists found that Ryk—an atypical Wnt receptor with a pseudokinase domain—had a Wnt-modulating effect in bone marrow stromal cells to control hematopoiesis-supporting activities.
[Experimental and Molecular Medicine]
Jeong, S.-Y., Lyu, J., Kim, J.-A., & Oh, I.-H. (2020). Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0477-y Cite
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Probucol Enhances the Therapeutic Efficiency of Mesenchymal Stem Cells in the Treatment of Erectile Dysfunction in Diabetic Rats by Prolonging their Survival Time via Nrf2 Pathway

The authors investigated therapeutic efficiency and potential mechanism of probucol combined with mesenchymal stem cells.
[Stem Cell Research & Therapy]
Wang, H., Zhang, K., Ruan, Z., Sun, D., Zhang, H., Lin, G., Hu, L., Zhao, S., & Fu, Q. (2020). Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Research & Therapy, 11(1), 302. https://doi.org/10.1186/s13287-020-01788-3 Cite
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Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
Yang, Y., Cao, T.-T., Tian, Z.-M., Gao, H., Wen, H.-Q., Pang, M., He, W.-J., Wang, N.-X., Chen, Y.-Y., Wang, Y., Li, H., Lin, J.-W., Kang, Z., Li, M.-M., Liu, B., & Rong, L.-M. (2020). Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Experimental Cell Research, 112184. https://doi.org/10.1016/j.yexcr.2020.112184 Cite
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Transplantation of R-GSIK Scaffold with Mesenchymal Stem Cells Improves Neuroinflammation in a Traumatic Brain Injury Model

Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
Sahab Negah, S., Shirzad, M. M., Biglari, G., Naseri, F., Hosseini Ravandi, H., Hassani Dooghabadi, A., & Gorji, A. (2020). Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03247-0 Cite
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Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells

C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
Dai, S., Kong, F., Liu, C., Xiao, F., Dong, X., Zhang, Y., & Wang, H. (n.d.). Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11432 Cite
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