Spontaneous Apoptosis of Cells in Therapeutic Stem Cell Preparation Exert Immunomodulatory Effects through Release of Phosphatidylserine

The authors revealed that dead MSCs alone in the therapeutic stem cell preparation or the apoptotic cells induced in vivo may exert the same immunomodulatory property as the “living MSCs preparation” through releasing phosphatidylserine, which was further recognized by Mer tyrosine kinase and participated in modulating immune cells.
[Signal Transduction and Targeted Therapy]
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Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation

Investigators proposed an approach based on triboelectric stimulation to rejuvenate senescent bone marrow MSCs by fabricating a pulsed triboelectric nanogenerator that could produce stable pulsed current output unaffected by the triggered frequency.
[Advanced Science]
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An Implantable Human Stem Cell-Derived Tissue-Engineered Rostral Migratory Stream for Directed Neuronal Replacement

The authors demonstrated that astrocyte-like-cells could be derived from adult human gingiva mesenchymal stem cells and used for Tissue-Engineered-rostral migratory stream fabrication.
[Communications Biology]
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Enhanced Cellular Engraftment of Adipose-Derived Mesenchymal Stem Cell Spheroids by Using Nanosheets as Scaffolds

Researchers showed an effective method for transplantation of adipose-derived MSCs spheroids onto skin wounds in order to efficiently cure refractory ulcers.
[Scientific Reports]
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Comparison of Mesenchymal Stromal Cells from Peritoneal Dialysis Effluent with Those from Umbilical Cords: Characteristics and Therapeutic Effects on Chronic Peritoneal Dialysis in Uremic Rats

Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.
[Stem Cell Research & Therapy]
Du, Y., Zong, M., Guan, Q., Huang, Z., Zhou, L., Cai, J., da Roza, G., Wang, H., Qi, H., Lu, Y., & Du, C. (2021). Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats. Stem Cell Research & Therapy, 12(1), 398. https://doi.org/10.1186/s13287-021-02473-9 Cite
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Cell Heterogeneity, Rather than the Cell Storage Solution, Affects the Behavior of Mesenchymal Stem Cells In Vitro and In Vivo

Scientists investigated the effects of storage solutions and heterogeneity on the behavior of MSCs in vitro and in vivo.
[Stem Cell Research & Therapy]
Wang, Y.-H., Tao, Y.-C., Wu, D.-B., Wang, M.-L., Tang, H., & Chen, E.-Q. (2021). Cell heterogeneity, rather than the cell storage solution, affects the behavior of mesenchymal stem cells in vitro and in vivo. Stem Cell Research & Therapy, 12(1), 391. https://doi.org/10.1186/s13287-021-02450-2 Cite
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Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Pulmonary Fibrosis via Regulatory T Cell through Interaction with Macrophage

The molecular and cellular behavior of human umbilical cord MSC was investigated in a bleomycin-induced mouse pulmonary fibrosis model.
[Stem Cell Research & Therapy]
Tang, Z., Gao, J., Wu, J., Zeng, G., Liao, Y., Song, Z., Liang, X., Hu, J., Hu, Y., Liu, M., & Li, N. (2021). Human umbilical cord mesenchymal stromal cells attenuate pulmonary fibrosis via regulatory T cell through interaction with macrophage. Stem Cell Research & Therapy, 12(1), 397. https://doi.org/10.1186/s13287-021-02469-5 Cite
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Influence of the Mesenchymal Stromal Cell Source on the Hematopoietic Supportive Capacity of Umbilical Cord Blood-Derived CD34+-Enriched Cells

The authors compared the capacity of BM-, umbilical cord matrix-, and adipose tissue-derived MSC, expanded with/without xenogeneic components, to expand/maintain umbilical cord blood CD34+-enriched cells ex vivo.
[Stem Cell Research & Therapy]
Bucar, S., Branco, A. D. de M., Mata, M. F., Milhano, J. C., Caramalho, Í., Cabral, J. M. S., Fernandes-Platzgummer, A., & da Silva, C. L. (2021). Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells. Stem Cell Research & Therapy, 12(1), 399. https://doi.org/10.1186/s13287-021-02474-8 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve the Function of Liver in Rats with Acute-on-Chronic Liver Failure via Downregulating Notch and Stat1/Stat3 Signaling

Researchers investigated the therapeutic potential of human umbilical cord-derived MSCs in acute-on-chronic liver injury (ACLI) and ACLF rat models.
[Stem Cell Research & Therapy]
He, Y., Guo, X., Lan, T., Xia, J., Wang, J., Li, B., Peng, C., Chen, Y., Hu, X., & Meng, Z. (2021). Human umbilical cord-derived mesenchymal stem cells improve the function of liver in rats with acute-on-chronic liver failure via downregulating Notch and Stat1/Stat3 signaling. Stem Cell Research & Therapy, 12(1), 396. https://doi.org/10.1186/s13287-021-02468-6 Cite
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Glycemic Control by Umbilical Cord-Derived Mesenchymal Stem Cells Promotes Effects of Fasting-Mimicking Diet on Type 2 Diabetic Mice

The authors investigated the efficacy comparison and interaction between fasting-mimicking diet and umbilical cord-derived-MSC infusion, aiming to establish effective type 2 diabetes therapies and explore its mechanism.
[Stem Cell Research & Therapy]
Zhao, N., Gao, Y.-F., Bao, L., Lei, J., An, H.-X., Pu, F.-X., Cheng, R.-P., Chen, J., Ni, H., Sui, B.-D., Ji, F.-P., & Hu, C.-H. (2021). Glycemic control by umbilical cord-derived mesenchymal stem cells promotes effects of fasting-mimicking diet on type 2 diabetic mice. Stem Cell Research & Therapy, 12(1), 395. https://doi.org/10.1186/s13287-021-02467-7 Cite
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miR-100-5p in Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Mediates Eosinophilic Inflammation to Alleviate Atherosclerosis via the FZD5/Wnt/β-Catenin Pathway

Exosome marker protein levels were increased in the exosomes derived from human umbilical cord MSCs (hUMSC-Ex) compared with those in hUMSC suspension, indicating that exosomes were successfully isolated from hUMSCs.
[Acta Biochimica et Biophysica Sinica]
Gao, H., Yu, Z., Li, Y., & Wang, X. (2021). miR-100-5p in human umbilical cord mesenchymal stem cell–derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway. Acta Biochimica et Biophysica Sinica, gmab093. https://doi.org/10.1093/abbs/gmab093 Cite
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