Although the basal transcriptomes of adipocyte-derived induced multipotent stem cells and adipose tissue–derived MSCs were similar, changes were observed in histone modifications and CpG methylation at cis-regulatory regions consistent with an epigenetic landscape that was primed for tissue development and differentiation.
[Science Advances]
Yeola, A., Subramanian, S., Oliver, R. A., Lucas, C. A., Thoms, J. A. I., Yan, F., Olivier, J., Chacon, D., Tursky, M. L., Srivastava, P., Potas, J. R., Hung, T., Power, C., Hardy, P., Ma, D. D., Kilian, K. A., McCarroll, J., Kavallaris, M., Hesson, L. B., … Pimanda, J. E. (2021). Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine. Science Advances, 7(3), eabd1929. https://doi.org/10.1126/sciadv.abd1929 Cite
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