Dual Effects of Hypoxia on Proliferation and Osteogenic Differentiation of Mouse Clonal Mesenchymal Stem Cells

Mouse clonal MSCs were cultured on a Cytodex 3 microcarrier in a spinner flask for a suspension culture under hypoxia condition to increase mass productivity.
[Bioprocess and Biosystems Engineering]
Kim, H., & Kwon, S. (2021). Dual effects of hypoxia on proliferation and osteogenic differentiation of mouse clonal mesenchymal stem cells. Bioprocess and Biosystems Engineering. https://doi.org/10.1007/s00449-021-02563-1 Cite
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Exosome-Eluting Stents for Vascular Healing after Ischaemic Injury

Researchers showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhanced vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
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Exosome-Eluting Stents for Vascular Healing after Ischemic Injury

The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering]
Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., Dinh, P.-U., Cores, J., & Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00705-0 Cite
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Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
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Efficacy of Topical and Systemic Transplantation of Mesenchymal Stem Cells in a Rat Model of Diabetic Ischemic Wounds

Scientists compared the effects of topical and systemic transplantation mesenchymal stem cells on diabetic ischemic wound healing and explored the underlying mechanisms.
[Stem Cell Research & Therapy]
Yan, J., Liang, J., Cao, Y., El Akkawi, M. M., Liao, X., Chen, X., Li, C., Li, K., Xie, G., & Liu, H. (2021). Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds. Stem Cell Research & Therapy, 12(1), 220. https://doi.org/10.1186/s13287-021-02288-8 Cite
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Small Extracellular Vesicles Derived from Interferon-γ Pre-Conditioned Mesenchymal Stromal Cells Effectively Treat Liver Fibrosis

Investigators analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs).
[NPJ Regenerative Medicine]
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Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy]
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A Composite Scaffold of Wharton’s Jelly and Chondroitin Sulphate Loaded with Human Umbilical Cord Mesenchymal Stem Cells Repairs Articular Cartilage Defects in Rat Knee

In vitro experiments involved identification of the human umbilical cord MSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of Wharton’s jelly (WJ) and chondroitin sulfate, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold.
[Journal of Materials Science-Materials in Medicine]
Li, Z., Bi, Y., Wu, Q., Chen, C., Zhou, L., Qi, J., Xie, D., Song, H., Han, Y., Qu, P., Zhang, K., Wu, Y., & Yin, Q. (2021). A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee. Journal of Materials Science: Materials in Medicine, 32(4), 36. https://doi.org/10.1007/s10856-021-06506-w Cite
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Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Attenuate the Inflammation of Severe Steroid-Resistant Asthma by Reshaping Macrophage Polarization

Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
[Stem Cell Research & Therapy]
Dong, B., Wang, C., Zhang, J., Zhang, J., Gu, Y., Guo, X., Zuo, X., Pan, H., Hsu, A. C.-Y., Wang, G., & Wang, F. (2021). Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Research & Therapy, 12(1), 204. https://doi.org/10.1186/s13287-021-02244-6 Cite
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Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., Zheng, H., & Cao, Z. (2021). Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals. https://doi.org/10.1089/cbr.2020.3855 Cite
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Impaired Regenerative Capacity and Senescence-Associated Secretory Phenotype in Mesenchymal Stromal Cells from Samples of Patients with Aseptic Joint Arthroplasty Loosening

Investigators compared the regenerative and differentiation capacity of MSCs derived from patients undergoing primary total hip arthroplasty to MSC derived from patients undergoing revision surgery after aseptic loosening of total hip and knee joint implants
[Journal of Orthopaedic Research]
Regina, E., Manuel, W., Clemens, B., Mike, W., Marietta, H., Sigrid, M.-D., Melanie, K., Franz, J., & Maximilian, R. (n.d.). Impaired regenerative capacity and senescence-associated secretory phenotype in mesenchymal stromal cells from samples of patients with aseptic joint arthroplasty loosening. Journal of Orthopaedic Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jor.25041 Cite
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