Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.
[International Immunopharmacology]
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Healthy versus Inflamed Lung Environments Differentially Affect Mesenchymal Stromal Cells

Scientists comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome lungs versus the lung environment present in healthy volunteers alters MSC behavior.
[European Respiratory Journal]
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SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.
[Journal of Molecular Histology]
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Transcriptomic Profiling and Functional Prediction Reveal Aberrant Expression of Circular RNAs during Osteogenic Differentiation in Human Umbilical Cord Mesenchymal Stromal Cells

Investigators analyzed RNA-sequence data to reveal expression profiles of circRNAs during osteogenesis of human umbilical cord MSCs, then elucidated the underlying mechanisms of action.
[Scientific Reports]
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Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D-Bioassembly Model

A facile 3D-bioassembly platform was introduced to primarily study fusion of cartilage–cartilage interfaces using spheroids formed from human MSCs and articular chondrocytes.
[Advanced Science]
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Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells

The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.
[Stem Cell Research & Therapy]
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Recellularization of Xenograft Heart Valves Reduces the Xenoreactive Immune Response in an In Vivo Rat Model

Explanted aortic valve constructs from female Hartley guinea pigs were procured and decellularized, followed by recellularization with autologous Sprague-Dawley rat mesenchymal stem cells.
[European Journal of Cardio-Thoracic Surgery]
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Bone Marrow CD73+ Mesenchymal Stem Cells Display Increased Stemness In Vitro and Promote Fracture Healing In Vivo

The authors showed that isolated CD73-EGFP+ MSCs displayed more pronounced stemness and stronger in vitro differentiation capacity into the osteogenic lineage compared to CD73-EGFP−MSCs.
[Bone Reports]
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The Role of miRNAs 340-5p, 92a-3p, and 381-3p in Patients with Endometriosis: A Plasma and Mesenchymal Stem-Like Cell Study

Peripheral blood and endometrial (e)MSC specimens were collected from suspected women of endometriosis before laparoscopy. Total RNA was isolated from plasma and cultured eMSCs to synthesize complementary DNA.
[Biomed Research International]
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H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Scientists treated ulcerative colitis animals with MSC preconditioned with or without H19 and compared the therapeutic effect of MSC and MSC-H19.
[Disease Markers]
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Conquering the Cytokine Storm in COVID-19-Induced ARDS Using Placenta-Derived Decidua Stromal Cells

Researchers conducted a safety and efficacy study that included ten patients with a median age of 50 years with COVID-19-induced acute respiratory distress syndrome (ARDS).
[Journal of Cellular and Molecular Medicine]
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