Although the basal transcriptomes of adipocyte-derived induced multipotent stem cells and adipose tissue–derived MSCs were similar, changes were observed in histone modifications and CpG methylation at cis-regulatory regions consistent with an epigenetic landscape that was primed for tissue development and differentiation.
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Yeola, A., Subramanian, S., Oliver, R. A., Lucas, C. A., Thoms, J. A. I., Yan, F., Olivier, J., Chacon, D., Tursky, M. L., Srivastava, P., Potas, J. R., Hung, T., Power, C., Hardy, P., Ma, D. D., Kilian, K. A., McCarroll, J., Kavallaris, M., Hesson, L. B., … Pimanda, J. E. (2021). Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine. Science Advances, 7(3), eabd1929. https://doi.org/10.1126/sciadv.abd1929 Cite
The authors assessed the potential anti-inflammatory effects of human umbilical cord MSC-derived extracellular vesicles in a rat model of chronic obstructive pulmonary disease.
[Stem Cell Research & Therapy]
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Ridzuan, N., Zakaria, N., Widera, D., Sheard, J., Morimoto, M., Kiyokawa, H., Mohd Isa, S. A., Chatar Singh, G. K., Then, K.-Y., Ooi, G.-C., & Yahaya, B. H. (2021). Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD). Stem Cell Research & Therapy, 12(1), 54. https://doi.org/10.1186/s13287-020-02088-6 Cite
Scientists investigated freshly isolated, uncultured umbilical cord (UC)-MSCs by single-cell RNA sequencing and found two populations of UC-MSCs.
[Stem Cell Research & Therapy]
Human umbilical cord-derived mesenchymal stem cells were successfully cultured and identified, and exosomes were isolated from the supernatant by ultracentrifugation.
[Stem Cell Research & Therapy]
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Li, D., Zhang, J., Liu, Z., Gong, Y., & Zheng, Z. (2021). Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial–mesenchymal transition by targeting HOXC6. Stem Cell Research & Therapy, 12(1), 24. https://doi.org/10.1186/s13287-020-02064-0 Cite
Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).
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Zu, Y., Zhou, J., Fu, Y., Fang, B., Liu, X., Zhang, Y., Yu, F., Zuo, W., Zhou, H., Gui, R., Li, Z., Liu, Y., Zhao, H., Zhang, C., & Song, Y. (2021). Feasibility of reduced-dose posttransplant cyclophosphamide and cotransplantation of peripheral blood stem cells and umbilical cord-derived mesenchymal stem cells for SAA. Scientific Reports, 11(1), 253. https://doi.org/10.1038/s41598-020-80531-7 Cite
Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful (MSC differentiation. Researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
[Cell Death & Disease]
Investigators evaluated two properties of a novel source of MSCs- first trimester human umbilical cord perivascular cells- that may render them a promising candidate for chemotherapeutic gonadal injury prevention.
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Zohni, K., Lopez, L., Mander, P., Szaraz, P., Filice, M., Wyse, B. A., Garcia, M., Gat, I., Glass, K., Gauthier-Fisher, A., & Librach, C. L. (2020). Human umbilical cord perivascular cells maintain regenerative traits following exposure to cyclophosphamide. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.12.035 Cite
Hematopoietic stem progenitor cells from cord blood were cocultured with growth-arrested adipose mesenchymal stromal cells. Commitment-related transcriptional and secretory profiles as well as hematopoiesis-supportive activity of intact and osteo-induced MSCs were examined.
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Buravkova, L. B., Ezdakova, M. I., Andrianova, I. V., Gornostaeva, A. N., Bobyleva, P. I., & Andreeva, E. R. (2020). Сord blood hematopoietic stem cells ex vivo enhance the bipotential commitment of adipose mesenchymal stromal progenitors. Life Sciences, 118970. https://doi.org/10.1016/j.lfs.2020.118970 Cite
The authors demonstrated that umbilical cord tissue-MSCs could be easily isolated without expensive enzymatic treatment or columns and reprogramed well using episomal vectors, which could allow for the removal of the reprogramming factors after a few passages.
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Mohamed, A., Chow, T., Whiteley, J., Fantin, A., Sorra, K., Hicks, R., & Rogers, I. M. (2021). Umbilical Cord Tissue as a Source of Young Cells for the Derivation of Induced Pluripotent Stem Cells Using Non-Integrating Episomal Vectors and Feeder-Free Conditions. Cells, 10(1), 49. https://doi.org/10.3390/cells10010049 Cite
Low-dose Ultrashort Wave was treated one day after spinal cord injury (SCI) and human umbilical cord mesenchymal stem cell suspension was transferred to the lesion using a micro-syringe seven days after SCI.
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Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
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Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite