mesenchymal stem cells

[Science Advances] Investigators reported that exosomes from MSCs administered as eye drops notably alleviated graft-versus-host disease-associated dry eye disease by suppressing inflammation and improving epithelial recovery in mice and humans.

[Advanced Science] The authors found that irisin pretreatment increased the cardiac homing of adipose tissue-derived MSCs administered by single and multiple intravenous injections to mice with myocardial ischemia-reperfusion (MI/R) by more than fivefold, which subsequently increased their antiapoptotic, proangiogenic, and antifibrotic effects in rats and mice that underwent MI/R.

[Clinical Reviews in Allergy & Immunology] The authors overview the current knowledge regarding the therapeutic efficacy of MSCs in systemic sclerosis (SSc), focusing on progresses reported in preclinical and clinical studies using MSCs, as well as challenges and future directions of MSC transplantation as a treatment option for patients with SSc.

[Stem Cell Research & Therapy] Scientists summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following peripheral nerve injuries with a focus on the immunosuppressive role of MSCs.

[Sorrento Therapeutics, Inc.] Sorrento Therapeutics, Inc. announced receipt of clearance from ANVISA to proceed with a Phase IIa randomized, placebo-controlled study of intravenous allogeneic adipose-derived MSC to treat post COVID-19 “long haul” pulmonary compromise.

[Scientific Reports] Scientists performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon.