Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
Yang, Y., Cao, T.-T., Tian, Z.-M., Gao, H., Wen, H.-Q., Pang, M., He, W.-J., Wang, N.-X., Chen, Y.-Y., Wang, Y., Li, H., Lin, J.-W., Kang, Z., Li, M.-M., Liu, B., & Rong, L.-M. (2020). Subarachnoid transplantation of human umbilical cord mesenchymal stem cell in rodent model with subacute incomplete spinal cord injury: Preclinical safety and efficacy study. Experimental Cell Research, 112184. https://doi.org/10.1016/j.yexcr.2020.112184 Cite
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Transplantation of R-GSIK Scaffold with Mesenchymal Stem Cells Improves Neuroinflammation in a Traumatic Brain Injury Model

Investigators determined the ability of the R-GSIK scaffold in supporting the effects of mesenchymal stem cells on motor function activity and inflammatory responses in an experimental traumatic brain injury model.
[Cell and Tissue Research]
Sahab Negah, S., Shirzad, M. M., Biglari, G., Naseri, F., Hosseini Ravandi, H., Hassani Dooghabadi, A., & Gorji, A. (2020). Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model. Cell and Tissue Research. https://doi.org/10.1007/s00441-020-03247-0 Cite
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Effect of Simulated Microgravity Conditions of Hindlimb Unloading on Mice Hematopoietic and Mesenchymal Stromal Cells

C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
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Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhance Angiogenesis In Vivo at a Low-Cell Dose

Researchers demonstrated the biophysical and biochemical effects of preconditioning human mesenchymal stem cells for 96 hours on a three-dimensional extracellular matrix-based microgel platform.
[Proceedings of the National Academy of Sciences of the United States of America]
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Intranasal Delivery of Mesenchymal Stem Cell Secretome Repairs the Brain of Alzheimer’s Mice

Researchers demonstrated that in vivo systemic administration of secretome collected from MSC exposed in vitro to Alzheimer’s disease (AD) mouse brain homogenates, fully replicated the cell-mediated neuroreparative effects in APP/PS1 AD mice.
[Cell Death & Differentiation]
Santamaria, G., Brandi, E., Vitola, P. L., Grandi, F., Ferrara, G., Pischiutta, F., Vegliante, G., Zanier, E. R., Re, F., Uccelli, A., Forloni, G., de Rosbo, N. K., & Balducci, C. (2020). Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer’s mice. Cell Death & Differentiation, 1–16. https://doi.org/10.1038/s41418-020-0592-2 Cite
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Glucocorticoid Priming of Nonviral Gene Delivery to Human Mesenchymal Stem Cells Increases Transfection by Reducing Induced Stresses

Scientists showed that transgene expression enhancement was mediated by transcriptional activation of endogenous human MSC genes by the cytosolic glucocorticoid receptor.
[Molecular Therapy-Methods & Clinical Development]
Hamann, A., Kozisek, T., Broad, K., & Pannier, A. K. (2020). Glucocorticoid Priming of Nonviral Gene Delivery to Human Mesenchymal Stem Cells Increases Transfection by Reducing Induced Stresses. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.07.014 Cite
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Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway

When co-culturing osteosarcoma (OS) cells with bone marrow-derived mesenchymal stem cells (BMSCs) in vitro, scientists validated that oncogenic LCP1 in OS was transferred from BMSCs via exosomes.
[Molecular Therapy-Nucleic Acids]
Ge, X., Liu, W., Zhao, W., Feng, S., Duan, A., Ji, C., Shen, K., Liu, W., Zhou, J., Jiang, D., Rong, Y., Gong, F., Wang, J., Xu, Z., Li, X., Fan, J., Wei, Y., Bai, J., & Cai, W. (2020). Exosomal transfer of LCP1 promotes osteosarcoma cell tumorigenesis and metastasis by activating the JAK2/STAT3 signaling pathway. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.07.025 Cite
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Inhibition of Circulating miR-194-5p Reverses Osteoporosis through Wnt5a/β-Catenin Signaling-Dependent Induction of Osteogenic Differentiation

Investigators found that aberrant expression of LCP1 could induce the proliferation and metastasis of osteosarcoma cells in vitro and in vivo by destabilizing neuregulin receptor degradation protein-1 and subsequently activating the JAK2/STAT3 signaling pathway.
[Molecular Therapy-Nucleic Acids]
Mi, B., Yan, C., Xue, H., Chen, L., Panayi, A. C., Hu, L., Hu, Y., Cao, F., Sun, Y., Zhou, W., Xiong, Y., & Liu, G. (2020). Inhibition of circulating miR-194-5p reverses osteoporosis through Wnt5a/β-catenin signaling-dependent induction of osteogenic differentiation. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.07.023 Cite
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Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma

Researchers describe the considerable effort taken to overcome chemotherapy resistance in sarcoma cells.
[Molecular Diagnosis & Therapy]
Mastoraki, A., Schizas, D., Vlachou, P., Melissaridou, N. M., Charalampakis, N., Fioretzaki, R., Kole, C., Savvidou, O., Vassiliu, P., & Pikoulis, E. (2020). Assessment of Synergistic Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Sarcoma. Molecular Diagnosis & Therapy. https://doi.org/10.1007/s40291-020-00487-2 Cite
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Renal Progenitor Cells Have Higher Genetic Stability and Lower Oxidative Stress than Mesenchymal Stem Cells during In Vitro Expansion

Investigators evaluate the evolution of genetic stability, viability, and oxidative stress of bone marrow mesenchymal stem cells and renal progenitor cells of the renal cortex of swine in culture passages.
[Oxidative Medicine and Cellular Longevity]
de Freitas Siqueira Silva, E. R. D., Neto, N. M. A., de Oliveira Bezerra, D., de Moura Dantas, S. M. M., dos Santos Silva, L., da Silva, A. A., de Moura, C. R. C., Júnior, A. L. G., Braz, D. C., Costa, J. R. F., de Carvalho Leite, Y. K., & de Carvalho, M. A. M. (2020, July 10). Renal Progenitor Cells Have Higher Genetic Stability and Lower Oxidative Stress than Mesenchymal Stem Cells during In Vitro Expansion [Research Article]. Oxidative Medicine and Cellular Longevity. https://doi.org/https://doi.org/10.1155/2020/6470574 Cite
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DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients during Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure

A cohort of eight pediatric cereberal palsy (CP) patients with intact corticospinal tracts from a randomized, placebo‐controlled trial of autologous umbilical cord blood stem‐cell therapy in CP children was included in this study.
[Journal of Magnetic Resonance Imaging]
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Loss of p53 in Mesenchymal Stem Cells Promotes Alteration of Bone Remodeling through Negative Regulation of Osteoprotegerin

Scientists showed by microCT that mice with p53 deletion systemically or specifically in mesenchymal cells possess significantly higher bone density than their respective littermate controls.
[Cell Death & Differentiation]
Velletri, T., Huang, Y., Wang, Y., Li, Q., Hu, M., Xie, N., Yang, Q., Chen, X., Chen, Q., Shou, P., Gan, Y., Candi, E., Margherita, A.-P., Agostini, M., Yang, H., Melino, G., Shi, Y., & Wang, Y. (2020). Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin. Cell Death & Differentiation, 1–14. https://doi.org/10.1038/s41418-020-0590-4 Cite
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