Lyophilized Powder of Mesenchymal Stem Cell Supernatant Attenuates Acute Lung Injury through the IL-6–P-STAT3–p63–JAG2 Pathway

Intratracheal bleomycin was used to induce acute lung injury in mice, and intratracheal MSCs in a supernatant lyophilized powder was administered as a treatment.
[Stem Cell Research & Therapy]
Peng, W., Chang, M., Wu, Y., Zhu, W., Tong, L., Zhang, G., Wang, Q., Liu, J., Zhu, X., Cheng, T., Li, Y., Chen, X., Weng, D., Liu, S., Zhang, H., Su, Y., Zhou, J., Li, H., & Song, Y. (2021). Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway. Stem Cell Research & Therapy, 12(1), 216. https://doi.org/10.1186/s13287-021-02276-y Cite
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Effect of Resveratrol and Mesenchymal Stem Cell Monotherapy and Combined Treatment in Management of Osteoporosis in Ovariectomized Rats: Role of SIRT1/FOXO3a and Wnt/β-Catenin Pathways

Researchers explored the effects and molecular mechanisms of resveratrol and MSC individual and combined treatment in management of osteoporosis in ovariectomized rats.
[Archives of Biochemistry and Biophysics]
Elseweidy, M. M., El-Swefy, S. E., Shaheen, M. A., Baraka, N. M., & Hammad, S. K. (2021). Effect of resveratrol and mesenchymal stem cell monotherapy and combined treatment in management of osteoporosis in ovariectomized rats: Role of SIRT1/FOXO3a and Wnt/β-catenin pathways. Archives of Biochemistry and Biophysics, 108856. https://doi.org/10.1016/j.abb.2021.108856 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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Sorrento Announces Updated Positive Results of Phase Ib Study of COVI-MSC™ for Treatment of ICU COVID-19 Patients

Sorrento Therapeutics, Inc. announced updated positive results from its Phase Ib study of human allogeneic adipose-derived MSCs for patients suffering from COVID-19-induced acute respiratory distress (ARD) or acute respiratory distress syndrome (ARDS).
[Sorrento Therapeutics, Inc. ]
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NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair

In vitro, nerve growth factor significantly improved the proliferation of human umbilical cord MSCs and mitigated cytotoxicity and apoptosis under hypoxic injury.
[American Journal of Physiology-Heart and Circulatory Physiology]
Luo, W., Gong, Y., Qiu, F., Yuan, Y., Jia, W., Liu, Z., & Gao, L. (2021). NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00855.2020 Cite
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Investigating Heterogeneities of Live Mesenchymal Stromal Cells Using AI-Based Label-Free Imaging

The authors developed an artificial intelligence (AI)-based method that converts transmitted light microscopy images of MSCs into quantitative measurements of protein expression levels.
[Scientific Reports]
Imboden, S., Liu, X., Lee, B. S., Payne, M. C., Hsieh, C.-J., & Lin, N. Y. C. (2021). Investigating heterogeneities of live mesenchymal stromal cells using AI-based label-free imaging. Scientific Reports, 11(1), 6728. https://doi.org/10.1038/s41598-021-85905-z Cite
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Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?

A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics in vivo requires advanced immune monitoring strategies.
[Frontiers in Immunology]
Stark, H. L., Wang, H. C., Kuburic, J., Alzhrani, A., Hester, J., & Issa, F. (2021). Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.664244 Cite
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Reversion of Early- and Late-Stage β-Cell Dedifferentiation by Human Umbilical Cord-Derived Mesenchymal Stem Cells in Type 2 Diabetic Mice

Investigators observed β-cell dedifferentiation in type 2 diabetes mellitus and investigated the reversal effect of umbilical cord-derived MSCs on early- and late-stage β-cell dedifferentiation.
[Cytotherapy]
Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y. (2021). Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.005 Cite
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Stem Cell Treatment Improves Post Stroke Neurological Outcomes: A Comparative Study in Male and Female Rats

Researchers hypothesised that MSC treatment would effectively promote the recovery of sensory and motor function in both males and females, despite any apparent sex differences in post-stroke brain injury.
[Stroke and Vascular Neurology]
Nalamolu, K. R., Chelluboina, B., Fornal, C. A., Challa, S. R., Pinson, D. M., Wang, D. Z., Klopfenstein, J. D., & Veeravalli, K. K. (2021). Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke and Vascular Neurology, svn. https://doi.org/10.1136/svn-2020-000834 Cite
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Biomimetic Cell-Adhesive Ligand-Functionalized Peptide Composite Hydrogels Maintain Stemness of Human Amniotic Mesenchymal Stem Cells

Scientists investigated the effects of the incorporation of cell-adhesive ligands in 3D self-assembling peptide hydrogels to modulate stem cell survival, proliferation, maintenance of stemness, and osteogenic differentiation.
[Regenerative Biomaterials]
Zhang, L., Xiong, N., Liu, Y., & Gan, L. (2021). Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells. Regenerative Biomaterials, 8(rbaa057). https://doi.org/10.1093/rb/rbaa057 Cite
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Corneal Reconstruction in Chemically Damaged Cornea Using Temperature Responsive Surface Assisted Mesenchymal Stem Cell Transplantation in Rabbits

Scientists investigated corneal reconstruction and tissue remodelling by transplantation of mesenchymal stem cells using temperature responsive membranes in chemically damaged rabbit cornea model.
[Graefe’s Archive for Clinical and Experimental Ophthalmology]
Sharma, J., Sharma, R. K., Gupta, P., Gupta, N., & Singh, N. (2021). Corneal reconstruction in chemically damaged cornea using temperature responsive surface assisted mesenchymal stem cell transplantation in rabbits. Graefe’s Archive for Clinical and Experimental Ophthalmology. https://doi.org/10.1007/s00417-021-05132-0 Cite
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