Tag Archives: mesenchymal stem cells

No account yet? Register

Review

Mesenchymal Stromal Cells: Putative Microenvironmental Modulators Become Cell Therapy

Scientists discuss potential mechanisms of action for the therapeutic effects of MSC transplantation, experimental models that dissect tissue modulating function of MSCs, and approaches for identifying MSC effects in vivo by integrating biomarkers of disease and MSC activity.

[Cell Stem Cell]

[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]

Abstract

No account yet? Register

Additional Benefit of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy on Sepsis Syndrome-Associated Acute Kidney Injury in Rat Treated with Antibiotic

Investigators tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells would offer an additional benefit to the rodent with acute kidney injury associated sepsis syndrome undergoing ciprofloxacin therapy.

[Stem Cell Research & Therapy]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Review

The Interaction of Helicobacter pylori with Cancer Immunomodulatory Stromal Cells: New Insight into Gastric Cancer Pathogenesis

The authors discuss the interplay between H. pylori and tumor-supportive cells, including mesenchymal stem cells, cancer-associated fibroblasts, tumor-associated macrophages, and myeloid derived-suppressor cells in gastric cancer.

[Seminars in Cancer Biology]

[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Abstract Graphical Abstract

Growth and Mineralization of Osteoblasts from Mesenchymal Stem Cells on Microporous Membranes: Epithelial-Like Growth with Transmembrane Resistance and pH Gradient

MSCs were characterized by flow cytometry with more than 90% CD44 and 75% Sca-1 labeling. Mineralization was validated with paracellular alkaline phosphatase activity, collagen birefringence, and mineral deposition confirming MSCs identity.

[Biochemical and Biophysical Research Communications]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Full Article Graphical Abstract

Comparing the Renoprotective Effects of BM-MSCs versus BM-MSC-Exosomes, When Combined with an Anti-Fibrotic Drug, in Hypertensive Mice

Scientists determined whether serelaxin (RLX) could enhance the therapeutic efficacy of bone-marrow-derived- mesecnymal stem cell-exosomes (BM-MSC-EXO), and compared the renoprotective effects of RLX and BM-MSC-EXO versus RLX and BM-MSCs in mice with hypertensive CKD.

[Biomedicine & Pharmacotherapy]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Abstract Graphical Abstract

Tailoring the Proliferation of Fibroblast Cells by Multiresponsive and Thermosensitive Stem Cells Composite F127 Hydrogel Containing Folic acid.MgO:ZnO/Chitosan Hybrid Microparticles for Skin Regeneration

The authors showed that F127 hydrogel containing FMZC is a suitable and nontoxic construct for encapsulation of MSCs in the presence of lysozyme and UVA irradiation, bearing high stem cell viability and proliferation.

[European Journal of Pharmaceutical Sciences]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Hop2 Interacts with the Transcription Factor CEBPα and Suppresses Adipocyte Differentiation

These in vitro data suggest that Hop2 inhibited adipogenesis by suppressing CEBP-mediated transactivation. Consistent with a negative role for Hop2 in adipogenesis, ablation of Hop2 in mice led to increased body weight, adipose volume, adipocyte size, and adipogenic marker gene expression.

[Journal of Biological Chemistry]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

No account yet? Register

Review

Stem Cell Therapy in Liver Regeneration: Focus on Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

Owing to the recent developments in mesenchymal stem cells and induced pluripotent stem cells, combined with emerging technologies including graphene, nano-biomaterials, and gene editing, precision medicine and individualized clinical treatment may be realized in the near future.

[Pharmacology & Therapeutics]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

Abstract

No account yet? Register

Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.

[Stem Cells and Development]

[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]

Abstract

No account yet? Register

Harnessing 3D Collagen Hydrogel-Directed Conversion of Human GMSCs into SCP-Like Cells to Generate Functionalized Nerve Conduits

Gingiva-derived mesenchymal stem cells (GMSCs) under 3D-culture in soft collagen hydrogel showed significantly increased expression of a panel of genes related to development/differentiation of neural crest stem-like cells and/or Schwann cell precursor-like cells and associated with NOTCH3 signaling pathway activation as compared to their 2D-cultured counterparts.

[NPJ Regenerative Medicine]

[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]