Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
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Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite
Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
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Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
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Liu, J., Feng, Y., Zeng, X., He, M., Gong, Y., & Liu, Y. (n.d.). Extracellular vesicles-encapsulated let-7i shed from bone mesenchymal stem cells suppress lung cancer via KDM3A/DCLK1/FXYD3 axis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.15866 Cite
IMAC Holdings, Inc. has completed the first infusion of its investigational compound utilizing umbilical cord-derived allogenic MSCs in its Phase I clinical trial for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinson’s disease.
[IMAC Holdings, Inc.]
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Researchers investigated the role of miR-199a-5p in T helper 17 (Th17) differentiation and determined whether extracellular vesicles derived from miR-199a-5p-modified adipose-derived MSCs could relieve immune thrombocytopenia by inhibiting Th17 differentiation.
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Li, J., Xia, Y., Fan, X., Wu, X., Yang, F., Hu, S., & Wang, Z. (2021). Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation. Laboratory Investigation, 1–10. https://doi.org/10.1038/s41374-020-00515-z Cite
The authors reveal that even under physiological conditions, MSCs produce and release a low level of tumor necrosis factor alpha (TNFα), unexpectedly required for preserving the self-renewal and differentiation of MSCs via autocrine/paracrine signaling.
The authors provide evidence that, upon their activation, platelets transfer respiratory-competent mitochondria to MSCs primarily via dynamin-dependent clathrin-mediated endocytosis.
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Levoux, J., Prola, A., Lafuste, P., Gervais, M., Chevallier, N., Koumaiha, Z., Kefi, K., Braud, L., Schmitt, A., Yacia, A., Schirmann, A., Hersant, B., Sid-Ahmed, M., Larbi, S. B., Komrskova, K., Rohlena, J., Relaix, F., Neuzil, J., & Rodriguez, A.-M. (2021). Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.12.006 Cite
Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.
[Signal Transduction and Targeted Therapy]
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Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., Shao, Z., Wang, M., Chen, D., Jin, W., Song, Y., Cao, H., Zhang, G., & Xiao, G. (2020). Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00328-y Cite
Incorporation of layered double hydroxide–miRNA nanoparticles into collagen-nanohydroxyapatite scaffolds resulted in successful overexpression of miRNA in mesenchymal stromal cells, demonstrating the development of an efficacious miRNA delivery platform for gene therapy applications in regenerative medicine.
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MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.
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To build a testing platform for advanced characterization of bone implants, investigators anchored model prosthetic titanium and stainless steel implants into decellularized bone scaffolds, seeded the implant-scaffold constructs with induced MSCs, and cultured the samples in an osteogenic environment in the presence of osteogenic inducing factors to grow bone tissue in vitro.
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