Umbilical Cord Mesenchymal Stem Cells for COVID-19 Acute Respiratory Distress Syndrome: A Double-Blind, Phase I/IIa, Randomized Controlled Trial

Scientists determined the safety and explored efficacy of umbilical cord mesenchymal stem cell infusions in subjects with COVID‐19 scute respiratory distress syndrome. A double‐blind, Phase I/IIa, randomized, controlled trial was performed.
[Stem Cells Translational Medicine]
Lanzoni, G., Linetsky, E., Correa, D., Cayetano, S. M., Alvarez, R. A., Kouroupis, D., Gil, A. A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., … Ricordi, C. (n.d.). Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/sctm.20-0472 Cite
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Olfactory Ecto-Mesenchymal Stem Cell-Derived Exosomes Ameliorate Murine Sjögren’s Syndrome by Modulating the Function of Myeloid-Derived Suppressor Cells

Scientists found that murine olfactory ecto-MSC-derived exosomes significantly enhanced the suppressive function of myeloid-derived suppressor cells by upregulating arginase expression and increasing ROS and NO levels.
[Cellular & Molecular Immunology]
Rui, K., Hong, Y., Zhu, Q., Shi, X., Xiao, F., Fu, H., Yin, Q., Xing, Y., Wu, X., Kong, X., Xu, H., Tian, J., Wang, S., & Lu, L. (2021). Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells. Cellular & Molecular Immunology, 1–12. https://doi.org/10.1038/s41423-020-00587-3 Cite
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Extracellular Vesicles‐Encapsulated let‐7i Shed from Bone Mesenchymal Stem Cells Suppress Lung Cancer via KDM3A/DCLK1/FXYD3 Axis

Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
Liu, J., Feng, Y., Zeng, X., He, M., Gong, Y., & Liu, Y. (n.d.). Extracellular vesicles-encapsulated let-7i shed from bone mesenchymal stem cells suppress lung cancer via KDM3A/DCLK1/FXYD3 axis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.15866 Cite
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IMAC Holdings Completes First Infusion of Stem Cells in Clinical Study for the Treatment of Bradykinesia Due to Parkinson’s Disease

IMAC Holdings, Inc. has completed the first infusion of its investigational compound utilizing umbilical cord-derived allogenic MSCs in its Phase I clinical trial for the treatment of bradykinesia, or the gradual slowing and loss of spontaneous body movement, due to Parkinson’s disease.
[IMAC Holdings, Inc.]
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Extracellular Vesicles Derived from miR-199a-5p-Modified Adipose-Derived Mesenchymal Stem Cells Alleviate Immune Thrombocytopenia by Inhibiting T Helper 17 Differentiation

Researchers investigated the role of miR-199a-5p in T helper 17 (Th17) differentiation and determined whether extracellular vesicles derived from miR-199a-5p-modified adipose-derived MSCs could relieve immune thrombocytopenia by inhibiting Th17 differentiation.
[Laboratory Investigation]
Li, J., Xia, Y., Fan, X., Wu, X., Yang, F., Hu, S., & Wang, Z. (2021). Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation. Laboratory Investigation, 1–10. https://doi.org/10.1038/s41374-020-00515-z Cite
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Mechanical Force-Driven TNFα Endocytosis Governs Stem Cell Homeostasis

The authors reveal that even under physiological conditions, MSCs produce and release a low level of tumor necrosis factor alpha (TNFα), unexpectedly required for preserving the self-renewal and differentiation of MSCs via autocrine/paracrine signaling.
[Bone Research]
Yu, W., Chen, C., Kou, X., Sui, B., Yu, T., Liu, D., Wang, R., Wang, J., & Shi, S. (2021). Mechanical force-driven TNFα endocytosis governs stem cell homeostasis. Bone Research, 8(1), 1–13. https://doi.org/10.1038/s41413-020-00117-x Cite
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Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming

The authors provide evidence that, upon their activation, platelets transfer respiratory-competent mitochondria to MSCs primarily via dynamin-dependent clathrin-mediated endocytosis.
[Cell Metabolism]
Levoux, J., Prola, A., Lafuste, P., Gervais, M., Chevallier, N., Koumaiha, Z., Kefi, K., Braud, L., Schmitt, A., Yacia, A., Schirmann, A., Hersant, B., Sid-Ahmed, M., Larbi, S. B., Komrskova, K., Rohlena, J., Relaix, F., Neuzil, J., & Rodriguez, A.-M. (2021). Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming. Cell Metabolism, 0(0). https://doi.org/10.1016/j.cmet.2020.12.006 Cite
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Kindlin-2 Regulates Skeletal Homeostasis by Modulating PTH1R in Mice

Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.
[Signal Transduction and Targeted Therapy]
Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., Shao, Z., Wang, M., Chen, D., Jin, W., Song, Y., Cao, H., Zhang, G., & Xiao, G. (2020). Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00328-y Cite
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Layered Double Hydroxide as a Potent Non-Viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

Incorporation of layered double hydroxide–miRNA nanoparticles into collagen-nanohydroxyapatite scaffolds resulted in successful overexpression of miRNA in mesenchymal stromal cells, demonstrating the development of an efficacious miRNA delivery platform for gene therapy applications in regenerative medicine.
[Pharmaceutics]
Pharmaceutics | Free Full-Text | Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications | HTML. (n.d.). Retrieved January 4, 2021, from https://www.mdpi.com/1999-4923/12/12/1219/htm Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Lupus through Increasing CD4+ T Cell Senescence via MiR-199a-5p/Sirt1/p53 Axis

MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.
[Theranostics]
Cheng, T., Ding, S., Liu, S., Li, Y., & Sun, L. (2021). Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics, 11(2), 893–905. https://doi.org/10.7150/thno.48080 Cite
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A Biomimetic Engineered Bone Platform for Advanced Testing of Prosthetic Implants

To build a testing platform for advanced characterization of bone implants, investigators anchored model prosthetic titanium and stainless steel implants into decellularized bone scaffolds, seeded the implant-scaffold constructs with induced MSCs, and cultured the samples in an osteogenic environment in the presence of osteogenic inducing factors to grow bone tissue in vitro.
[Scientific Reports]
Sladkova-Faure, M., Pujari-Palmer, M., Öhman-Mägi, C., López, A., Wang, H., Engqvist, H., & de Peppo, G. M. (2020). A biomimetic engineered bone platform for advanced testing of prosthetic implants. Scientific Reports, 10(1), 22154. https://doi.org/10.1038/s41598-020-78416-w Cite
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