The Potential Role of Mesenchymal Stem Cells in Modulating Anti-Aging Process

Investigators describe in detail ways MSCs may capitalize its paracrine properties in modulating antiaging process.
[Cell Biology International]
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Regional Specialization and Fate Specification of Bone Stromal Cells in Skeletal Development

Investigators showed with mouse genetics, ex vivo cell differentiation assays, and transcriptional profiling that mesenchymal stromal cells from bone from metaphysis and diaphysis were fundamentally distinct.
[Cell Reports]
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Cartilage from Human-Induced Pluripotent Stem Cells: Comparison with Neo-Cartilage From Chondrocytes and Bone Marrow Mesenchymal Stromal Cells

Scientists explored whether human-induced pluripotent stem cells could represent unlimited cell sources for neo-cartilage comparable to human primary articular chondrocytes or human bone marrow-derived MSCs.
[Cell and Tissue Research]
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Stem Cell Therapy Company Amniotics Raises SEK 60 Million before Deduction of Transaction Costs, in First North IPO to Advance Lead Candidate PulmoStem Into Clinic

Amniotics AB has raised SEK60 million through its recent listing on Nasdaq. The funds will now be deployed to advance the company’s preclinical portfolio of cell therapy candidates based on MSC from amniotic fluid. Lead candidate PulmoStem™, a first-in-class treatment for pulmonary disease is scheduled to enter the clinic.
[Amniotics AB]
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The Tissue Origin of Human Mesenchymal Stem Cells Dictates Their Therapeutic Efficacy on Glucose and Lipid Metabolic Disorders in Type II Diabetic Mice

Scientists report a comprehensive comparison of human MSCs derived from umbilical cord Wharton’s jelly (UC-MSCs), dental pulp, and adipose tissue on the treatment of glucose and lipid metabolic disorders in type II diabetic mice.
[Stem Cell Research & Therapy]
Ma, Y., Wang, L., Yang, S., Liu, D., Zeng, Y., Lin, L., Qiu, L., Lu, J., Chang, J., & Li, Z. (2021). The tissue origin of human mesenchymal stem cells dictates their therapeutic efficacy on glucose and lipid metabolic disorders in type II diabetic mice. Stem Cell Research & Therapy, 12(1), 385. https://doi.org/10.1186/s13287-021-02463-x Cite
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Application of Mesenchymal Stem Cell Sheet to Treatment of Ischemic Heart Disease

Umbilical cord (UC)-MSCs have few human leukocyte antigen-II and major histocompatibility complex class I molecules, and are easy to isolate and culture, UC-MSC sheets have been proposed as a candidate for clinical applications to ischemic heart disease.
[Stem Cell Research & Therapy]
Chang, D., Fan, T., Gao, S., Jin, Y., Zhang, M., & Ono, M. (2021). Application of mesenchymal stem cell sheet to treatment of ischemic heart disease. Stem Cell Research & Therapy, 12(1), 384. https://doi.org/10.1186/s13287-021-02451-1 Cite
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A SNAI2-PEAK1-INHBA Stromal Axis Drives Progression and Lapatinib Resistance in HER2-Positive Breast Cancer by Supporting Subpopulations of Tumor Cells Positive for Antiapoptotic and Stress Signaling Markers

Mesenchymal stem cells and cancer-associated fibroblasts expressed high PEAK1 protein levels and potentiated tumorigenesis, lapatinib resistance and metastasis of HER2-positive breast cancer cells in a PEAK1-dependent manner.
[Oncogene]
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The B56α Subunit of PP2A Is Necessary for Mesenchymal Stem Cell Commitment to Adipocyte

The authors reported the PP2A phosphatase B subunit B56α was specifically induced during adipocyte differentiation and mediated PP2A to dephosphorylate GSK3β, thereby blocking Wnt activity and driving adipocyte differentiation.
[EMBO Reports]
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3D Printing of Cu-Doped Bioactive Glass Composite Scaffolds Promotes Bone Regeneration through Activating the HIF-1α and TNF-α Pathway of hUVECs

Through in vitro tests, scientists found that copper-doped bioactive glass enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of human umbilical vein endothelial cells.
[Biomaterials Science]
Dai, Q., Li, Q., Gao, H., Yao, L., Lin, Z., Li, D., Zhu, S., Liu, C., Yang, Z., Wang, G., Chen, D., Chen, X., & Cao, X. (2021). 3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1α and TNF-α pathway of hUVECs. Biomaterials Science. https://doi.org/10.1039/D1BM00870F Cite
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Schwann Cells Promote Prevascularization and Osteogenesis of Tissue-Engineered Bone via Bone Marrow Mesenchymal Stem Cell-Derived Endothelial Cells

The authors cultured rat Schwann cells, aortic endothelial cells, and bone marrow-derived mesenchymal stem cells (BM-MSCs) and then obtained BM-MSC-derived induced endothelial cells and induced osteoblasts.
[Stem Cell Research & Therapy]
Zhang, X., Jiang, X., Jiang, S., Cai, X., Yu, S., & Pei, G. (2021). Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells. Stem Cell Research & Therapy, 12(1), 382. https://doi.org/10.1186/s13287-021-02433-3 Cite
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Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs

Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.
[Stem Cell Reports]
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