mesenchymal stem cells

[Journal of Nanobiotechnology] Researchers fabricated nanoparticles (NPs) using polylactic-co-glycolic acid loaded with the secretome (Sec) from MSCs to form MSC-Sec NPs.

[Aging Cell] The authors screened the gene expression profiles of human bone marrow MSCs (BMSCs) from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis.

[Stem Cell Research & Therapy] The authors investigated the therapeutic effect of human amniotic MSCs combined with polyethylene glycol citrate-co-N-isopropylacrylamide mixed with gelatin (PPCNg) transplantation in promoting the regeneration of injured endometrium.

[European Journal of Medical Research] Researchers investigated the biological and cytological characteristics of rabbit nucleus pulposus MSCs (NPMSCs) and determined the effect of the growth and differentiation factor-5 on the differentiation of rabbit NPMSCs transduced with a lentivirus vector.

[iScience] Scientists utilized a systems-based approach to compare MSCs from different genetic backgrounds that displayed differences in antibacterial activity.

[Small] Investigators showed that high frequency MHz-order mechanostimulation in the form of nanoscale amplitude surface reflected bulk waves were capable of triggering differentiation of human MSCs from various donor sources toward an osteoblast lineage, with early, short time stimuli inducing long-term osteogenic commitment.