Short-Duration High Frequency MegaHertz-Order Nanomechanostimulation Drives Early and Persistent Osteogenic Differentiation in Mesenchymal Stem Cells

Investigators showed that high frequency MHz-order mechanostimulation in the form of nanoscale amplitude surface reflected bulk waves were capable of triggering differentiation of human MSCs from various donor sources toward an osteoblast lineage, with early, short time stimuli inducing long-term osteogenic commitment.