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mesenchymal stem cells

Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway

[International Journal of Stem Cells] Researchers reported the effects of diesel exhaust particles exposure on the properties of human Wharton’s jelly-derived mesenchymal stem cells, including stemness, regeneration, and immunomodulation.

Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

[Brain Research Bulletin] Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.

Engineering of Human Mesenchymal Stem Cells Resistant to Multiple Natural Killer Subtypes

[International Journal of Biological Sciences] Efforts have been made to generate immune-escaping human embryonic stem cells where T cell immunity was evaded by defecting β-2-microglobulin, a common unit for human leukocyte antigen class I, and NK cells were inhibited via ectopic expression of HLA-E or -G.

Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate

[Tissue Engineering and Regenerative Medicine] Researchers reported a novel strategy to generate highly pure mouse bone marrow MSCs using liposomal clodronate.

Sodium Alginate Microencapsulation of Human Mesenchymal Stromal Cells Modulates Paracrine Signaling Response and Enhances Efficacy for Treatment of Established Osteoarthritis

[Acta Biomaterialia] Scientists assessed the effects of sodium alginate microencapsulation on human MSC secretion of immunomodulatory cytokines in an osteoarthritis (OA) microenvironment and therapeutic efficacy in treating established OA.

Overexpression of NMNAT3 Improves Mitochondrial Function and Enhances Anti-Oxidative Stress of Bone Marrow Mesenchymal Stem Cells via the NAD+-Sirt3 Pathway

[Bioscience Reports] Researchers confirmed that overexpression of nicotinamide mononucleotide adenylyl transferase 3 (NMNAT3) improved mitochondrial function and resistance to stress-induced apoptosis in bone marrow MSCs.

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