mesenchymal stem cells

[NPJ Regenerative Medicine] Gingiva-derived mesenchymal stem cells (GMSCs) under 3D-culture in soft collagen hydrogel showed significantly increased expression of a panel of genes related to development/differentiation of neural crest stem-like cells and/or Schwann cell precursor-like cells and associated with NOTCH3 signaling pathway activation as compared to their 2D-cultured counterparts.

[Stem Cell Reviews and Reports] The impact of 3D co-culture of human fetal pancreatic-derived mesenchymal cells with human embryonic stem cell-derived pancreatic progenitors development towards endocrine and beta cells was assessed.

[Scientific Reports] The authors evaluated enhanced therapeutic effects of tonsil-derived mesenchymal stem cells on a murine colitis model using 3D culture method.

[Advanced Healthcare Materials] Extracellular vesicles (EVs) derived from umbilical cord MSCs can achieve rapid cell proliferation and migration with little immune response by creating a satisfactory microenvironment. Fusion peptide-mediated EVs were able to modify the surface of the small intestinal submucosa membrane via specific combination.

[Cytokine] Researchers hypothesized that the chemokine/chemokine receptor axes network have crucial and efficacious impacts on behavior of the MSCs.

[Stem Cell Research & Therapy] Researchers investigated the effect of the combination of Wharton's jelly derived MSCs and high frequency repetitive electromagnetic stimulation in the therapy of toxic optic neuropathies with severe symptoms after the available current therapy modalities which were unsucessful.