mesenchymal stem cells

[npj Regenerative Medicine] By using a calvarial defect model, scientists showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged bone marrow MSC both in vitro and in vivo.

[Scientific Reports] Researchers investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.

[Biofabrication] Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.

[Cell Death & Disease] Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.

[Signal Transduction and Targeted Therapy] The authors examined the safety and efficacy of human umbilical cord mesenchymal stem cell infusion for immune non-responder patients with chronic HIV-1 infection, who represented an unmet medical need even in the era of efficient antiretroviral therapy.

[Scientific Reports] Scientists demonstrated that hPDLSCs, hBMSCs and hDPSCs could directly differentiate into neuron-like cells without passing through a mitotic stage and that they shrunk dramatically and changed their morphology to that of neuron-like cells through active neurite extension.