microglia

[Science Advances] Data suggest that following their initial central nervous system infiltration, T cells activate the microglial noncanonical NF-κB pathway, which synergizes with the T cell-derived cytokine granulocyte-macrophage colony-stimulating factor to induce expression of chemokines involved in the second-wave of T cell recruitment and disease progression.

[Nature Communications] Investigators generated a induced pluripotent stem cell Alzheimer's disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.

[Nature Communications] Researchers identified nodes of Ranvier as a direct site of interaction between microglia and axons, in both mouse and human tissues. Using dynamic imaging, they highlight the preferential interaction of microglial processes with nodes of Ranvier along myelinated fibers.

[Scientific Reports] Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.

[Cell Reports] Researchers showed that Grn knockout mice have increased microgliosis in white matter and an accumulation of myelin debris in microglial lysosomes in the same regions.

[Nature Medicine] Scientists tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain.